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WO/2024/085660A1 |
The present invention relates to a device and a method for predicting the risk of disease incidence by using the presence/absence of a single nucleotide polymorphism and a monogenic variation in an individual. The device and the method f...
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WO/2024/084059A1 |
Methods and products for discovering disease biomarkers and diagnosing disease are provided. RNA or cDNA samples are typically dominated by sequences from highly expressed genes which can negatively affect analysis of the samples. The pr...
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WO/2024/082681A1 |
Provided are a fusion protein, and a nucleic acid molecule comprising a nucleotide sequence encoding the fusion protein. The present invention also relates to a vaccine comprising the fusion protein or the nucleic acid molecule. Furtherm...
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WO/2024/086226A1 |
Methods and systems are disclosed for component deconvolution by a mixture model based on methylation information. A mixture model may be trained agnostic of labels or known component contributions. A system generates a methylation signa...
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WO/2024/082564A1 |
Disclosed in the present invention is a centrifugal micro-fluidic chip. The centrifugal micro-fluidic chip comprises a processing structure and a backflow structure which are sequentially arranged in a movement direction of a sample liqu...
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WO/2024/084249A1 |
The present invention provides methods for the preparation of clonal clusters of polynucleotides on surfaces and also provides surfaces comprising such clusters. The methods and tethered clonal clusters are particularly of use in nucleot...
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WO/2024/059773A3 |
Provided herein is a highly sensitive analyte detection method that involves catch and release of a target analyte coupled with a proximity assay. Target analyte is captured using a capture binding partner and is also bound by detection ...
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WO/2024/085608A1 |
The present invention relates to a cancer diagnosis method using exon-junction information of RNAs in the blood and, more particularly, to a method for analyzing transcriptomes in order to provide information required for cancer diagnosi...
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WO/2024/085143A1 |
The purpose of the present invention is to provide a novel peptide that could be used to induce an immune response to SARS-CoV-2. A nucleocapsid-derived antigen peptide according to the present disclosure includes the following polypep...
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WO/2024/083790A1 |
The present invention proposes an efficient method to prognose the evolution of a solid cancer in a subject in need thereof, by analysing the frequency of a particular subset of dendritic cells as well as their relative number as compare...
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WO/2024/085079A1 |
[Problem] SMN2 gene located in the vicinity of SMN1 gene is different from the SMN1 gene by only 5 bases. Thus, in order to perform an SMA screening test, it was necessary to establish a test system that can detect the SMN1 gene specific...
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WO/2024/084958A1 |
This detection device comprises a first well plate having a plurality of first wells on one side and a second well plate having a plurality of second wells on one side, wherein the first well plate and the second well plate are spaced ap...
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WO/2024/085141A1 |
This fluid device comprises a base plate and a wall material provided on the base plate, and includes a plurality of first wells surrounded by the base plate and the wall material, and a plurality of second wells provided respectively in...
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WO/2024/084460A1 |
Provided is a method for detecting a microbe in a sample comprising detecting confluence of the sample. Also provided is a method for assaying a test agent comprising adding the test agent to a sample comprising a microbe, and measuring ...
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WO/2024/084463A1 |
Provided is a method for detecting a microbe in a sample comprising measuring an infrared spectrum of the sample. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive. Als...
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WO/2024/084461A1 |
Provided is a method for detecting a microbe in a sample comprising measuring a Raman spectrum of the sample. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive and/or n...
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WO/2024/086745A2 |
The present disclosure provides systems and methods for analyzing or identifying a target nucleic acid molecule. For example, a system of the present disclosure may comprise (a) a complex comprising a target nucleic acid molecule and a p...
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WO/2024/084440A1 |
Provided herein are systems and methods for the enrichment and detection of nucleic acid molecules. In particular, provided herein are systems and methods for the selective enrichment of a desired nucleic acid molecule in a sample contai...
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WO/2024/084439A2 |
Provided herein are compositions and methods for the analysis of nucleic acids. In particular, provided herein are compositions and methods employing differential complementarity of probe nucleic acid molecules to target nucleic acids mo...
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WO/2024/059788A3 |
Provided is a method for labeling a nucleic acid, including providing a target nucleic acid to be labeled; providing a 5'-end glycosylase to react with the target nucleic acid to create an intermediate nucleic acid having an abasic site ...
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WO/2024/086493A1 |
The presently disclosed subject matter relates to an in vitro method for the diagnosis or follow-up of an inflammatory disorder in a Felidae. The presently disclosed subject matter also relates to compounds, and compositions thereof, for...
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WO/2024/044691A3 |
Disclosed herein are compositions comprising chemically modified adeno-associated viruses (AAV) engineered by chemical modification of capsid proteins, whether wildtype or engineered, and methods of using such modified AAVs for therapeut...
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WO/2024/086499A1 |
In some embodiments, a computer-implemented method of detecting a presence of a predetermined fusion gene in a biological sample is provided. A computing system generates an alignment of a read sequence to a reference genome. The alignme...
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WO/2024/059037A3 |
A method of positively detecting a target pathogen/molecule within a fluid sample and related test devices are described. The device includes a plurality of chambers in adjacent, spaced-apart relationship, and a plurality of isolation va...
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WO/2024/086776A1 |
The present disclosure relates generally to arrays for transcriptomics assays and methods of preparing the same. The disclosure provides arrays having features on a substrate and filling material in the spaces on the substrate that are n...
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WO/2024/086692A2 |
The present disclosure relates to compositions and methods for the treatment of neurological disorders.
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WO/2024/082430A1 |
A tumor microfluidic chip for screening mesenchymal stem cell migration, and a preparation and use method therefor. The microfluidic chip comprises a chip main body having a microstructure channel machined on the surface, and a substrate...
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WO/2023/196642A9 |
Novel approaches for processing polymeric analytes, such as biopolymers, are provided herein. A method for processing a polymeric analyte may comprise coupling a monomer of the polymeric analyte to a capture moiety, cleaving the monomer ...
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WO/2024/020543A3 |
The present disclosure features kits and methods for diagnosis and treatment of actinomycetia (e.g., corynebacteriales) infections, e.g., caused by mycobacterial cells. The methods include using a mixture of lytic enzymes to specifically...
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WO/2024/084281A1 |
The present invention relates to compositions and non-invasive methods for detecting cell death by detecting beta cell genomic DNA in a urine sample. The invention relates the discovery that the presence of hypomethylated beta cell DNA o...
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WO/2024/083867A1 |
A method for identifying a subject to whom a combination therapy is to be administered, wherein the subject is a cancer patient. The combination therapy comprises administration of: (I) a PD-1/PD-L1 immune checkpoint inhibitor and/or a C...
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WO/2024/083429A1 |
The present invention provides an antimicrobial agent for use in the treatment or prevention of a bacterial infection, wherein a patient is selected for treatment using the antimicrobial agent based on the level of D-lactate in a patient...
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WO/2024/085246A1 |
The purpose of the present invention is to provide: a biomarker which can determine the presence or absence of the affection of dementia with high sensitivity and specificity by means of a simple operation; and a method, a kit, and a dev...
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WO/2024/085195A1 |
Provided is an examination method for irAE enteritis, said examination method comprising a detection step for detecting, as an indicator of ulcerous colitis-like irAE enteritis, an antibody that immunologically reacts with a fragment of,...
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WO/2024/083895A1 |
The present invention relates to a polynucleotide encoding a mutated patatin phospholipase protein, which mutated protein leads to an improved haploid induction rate. The invention further relates to the mutant patatin phospholipase prot...
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WO/2024/083474A1 |
The invention relates to a microfluidic method for the combined cell-specific labelling and enrichment of biomarkers in a reaction compartment, comprising the following method steps: a) providing a microfluidic device comprising at least...
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WO/2024/086690A2 |
The present disclosure is directed, in some aspects to methods and compositions for the assessment of regulatory T cell stability over time. In other aspects, the present disclosure provides methods and compositions for expanding regulat...
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WO/2024/084458A1 |
The present disclosure relates to a method, assays for assessing TKI compliance and disease progression despite treatment in a subject. The present disclosure also relates to a combination of biological markers employed in the method for...
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WO/2024/085421A1 |
A sensing device is disclosed. In particular, a sensing device according to the present disclosure comprises: a concentration unit that concentrates an analyte contained in a sample; and a sensing unit that detects the type of the analyt...
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WO/2024/082624A1 |
Provided are a primer having stem-loop structures and the use thereof. The primer sequentially comprises, from the 5' end to the 3' end, primer region 1, inosines, stem-loop structure 1, primer region 2, stem-loop structure 2 and primer ...
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WO/2024/086755A2 |
The present disclosure provides multiplexed system with methods using a multiplex real-time polymerase chain reaction (qPCR), at-home collection and laboratory testing kits for detecting whether at least one or more sexual health conditi...
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WO/2024/086659A2 |
The current disclosure relates to methods, compositions and kits for detecting modified adenines in a target nucleic acid molecule. Aspects relate to a method for detecting modified adenines in a target nucleic acid such as a target deox...
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WO/2024/086515A1 |
Methods for predicting a cutaneous primary site of disease are described. The methods may comprise, for example, receiving, using one or more processors, sequence read data associated with a sample from the individual, selecting, using t...
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WO/2024/084421A1 |
The present invention provides methods of treatment, diagnostics, kits, and formulations for treating a subject having one or more genetic variations in an Actin alpha 2 (ACTA2) gene involving administering a therapeutically effective am...
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WO/2024/086681A1 |
The present invention provides methods and kits for detecting the presence of a dengue virus serotype in a sample as well as uses of these methods and kits in quality control of one or more vaccines containing live, attenuated dengue vir...
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WO/2024/085132A1 |
This biological substance treatment method involves preparing a flow cell 1 comprising: a chamber array device 11 provided with a plurality of chambers 14 in which one of the chambers is 1 nanoliter or less; and a cover body 21 defining ...
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WO/2024/086294A1 |
Technologies for writing information into a nucleic acid sequence include: determining a string of symbols to represent said information; constructing a plurality of components, wherein each individual component of said plurality of comp...
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WO/2024/086616A2 |
This disclosure relates to devices and methods for signaling transient and mechanical events associated with ligand receptor interactions. In certain embodiments, this disclosure contemplates devices for detecting ligand receptor binding...
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WO/2024/083061A1 |
The present invention belongs to the cross technique field of plant-microorganism, and specifically relates to a method for breeding an improved variety of a forage sorghum-bacillus megaterium symbiont. The method comprises the following...
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WO/2024/086373A1 |
Methods for diagnosing and trating Barrett's esophagus include the identification of biomarker panels.
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