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WO/2024/054272A2 |
Techniques are describing for designing and operating a quantum oscillator. In contrast with conventional approaches to operating a quantum oscillator, the present techniques relate to an oscillator design that has less bare nonlinearity...
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WO/2024/052917A1 |
Methods of treating cancer comprising reducing expression or function of eukaryotic initiation factor 4E-binding protein 1 (EIF4EBP1) or EIF4EBP2 in a cell of the cancer, wherein the function is binding Eukaryotic translation initiation ...
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WO/2024/051910A2 |
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WO/2024/052329A1 |
The invention concerns a method for determining the existence of or susceptibility to panic based upon the presence of serum sortilin related VPS10 domain containing receptor 3 (SORCS3); a kit for performing the afore method(s); at least...
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WO/2024/053519A1 |
Disclosed are a kit for diagnosing Alzheimer's disease and a pharmaceutical composition for treating Alzheimer's disease that use EDIL3 or a nucleic acid that encodes EDIL3 as an indicator or a target.
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WO/2024/054572A1 |
The present disclosure is directed to methods of using salivary exosomes to detect and treat Sjögren's syndrome in a subject.
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WO/2024/050817A1 |
Use of glycyrrhizic acid or a derivative thereof in nucleic acid detection. In particular, the present invention relates to a reagent comprising glycyrrhizic acid or a derivative thereof, use of glycyrrhizic acid or a derivative thereof ...
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WO/2024/054946A1 |
Described herein are methods for identifying a biological state such as pancreatic cancer in a subject. For example, a method may include obtaining protein data, transcriptomic data, genomic data, lipidomic data, or metabolomic data of a...
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WO/2024/054898A1 |
Disclosed herein include methods, compositions, and kits suitable for use in treating cancer in a subject. In some embodiments, the method comprises administration of onvansertib and a PART inhibitor (e.g., olaparib, niraparib, and AZD53...
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WO/2024/055019A1 |
Provided are methods and systems for detection of oral bacteria.
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WO/2024/050860A1 |
The present invention relates to the technical field of medical biology, and particularly, to use of RUNX2 as a marker in preparing a diagnosis or detection reagent for a malignant phyllodes tumor. The detection reagent can assist in, ac...
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WO/2024/051832A1 |
Disclosed in the present invention is a method for detecting the proportion of mRNA with a polyA tail in a mRNA product. The method comprises the following steps: 1) obtaining an RNA with an adapter at the 3' end; 2) performing reverse t...
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WO/2024/054662A2 |
Atomic force microscopy (AFM) can be used to image biological samples with low nanomolar resolution. Compared to other imaging modalities with nanoscale resolution, AFM does not require the use of complex, costly instrumentation or toxic...
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WO/2024/050591A1 |
The present invention provides a method of producing a composition capable of producing a food-like aroma and/or flavour when heated, comprising a) disrupting a Mortierella spp. biomass comprising phospholipids; b) fractionating the disr...
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WO/2024/054571A1 |
Embodiments of the present disclosure include compositions and methods for performing in situ hybridization reactions. In particular, the present disclosure provides RNA blocking molecules that enhance detection of a target RNA molecule ...
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WO/2024/054825A1 |
Disclosed herein include methods, compositions, and kits for detecting a plurality of nucleic acid sequences. The method can comprise amplifying a first nucleic acid sequence and a second nucleic acid sequence in an amplification reactio...
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WO/2024/053993A1 |
The present invention provides a method for providing information on classification of spontaneous or multiple primary lung cancer, implemented by a processor, and a device for providing information on classification of spontaneous or mu...
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WO/2024/050815A1 |
Provided is the use of heteroaromatic ring compounds in nucleic acid tests. Particularly provided are the use of heteroaromatic ring compounds as a nucleic acid protective agent in nucleic acid tests, a method for inhibiting degradation ...
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WO/2024/052842A1 |
The present invention relates to a non-invasive device (100) and method (400) for detecting RNA associated disease based on the activity of the biological sample. The device (100) and method (400) encompass passing of the biological samp...
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WO/2024/050859A1 |
The present invention relates to the technical field of animal cell line models. Disclosed are a human breast malignant phyllodes tumor cell strain and a progeny cell line and use thereof. The cell line is named Human Breast Malignant Ph...
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WO/2024/054632A2 |
In various embodiments alpha helical peptide-based bridges for molecular biosensing "on-chip" are disclosed. The Peptide-based bridges serve as common bridges for great diversity of biosensing applications and targets including nucleic a...
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WO/2024/054925A1 |
Disclosed are compositions, assays, methods, diagnostic methods, kits and diagnostic kits for the specific and differential detection of SARS-CoV-2, including SARS-CoV-2 variants, or other coronaviruses from samples including veterinary ...
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WO/2024/053588A1 |
The block for preparing an observation section according to the present disclosure is equipped with a cell assembly, the cell assembly being in a three-dimensional shape and embedded, and a continuous or intermittent marker extending in ...
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WO/2024/054431A1 |
Provided herein are immobilized polynucleotide templates and methods of producing immobilized polynucleotide templates. In some embodiments, the immobilized polynucleotide templates are single-stranded. In some embodiments, the immobiliz...
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WO/2024/050589A1 |
The present invention provides compositions comprising microbial biomass, one or more lactones and/or one or more 4-hydroxy fatty acids, as well as food products, beverage products or feedstuffs comprising microbial biomass, one or more ...
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WO/2024/052864A1 |
The invention relates to substantially complete vaginal microbiota preparations for treating infertility and therapeutic methods to do so.
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WO/2024/054897A1 |
The inventors hypothesized that the induction of a multitude of neoantigens in tumor cells, through hundreds of thousands of RNA editing events, would render tumors more recognizable by the patient's own T cells and that this could serve...
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WO/2024/053887A1 |
This invention relates to a Copine1 gene marker for prognosing the metastasis of HER2-positive breast cancer and a use thereof. Specifically, the present invention relates to a biomarker composition for prognosing the metastasis of HER2-...
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WO/2024/050858A1 |
A malignant human breast phyllodes tumor cell strain, a filial generation cell line thereof, and use thereof. The cell line is named malignant human breast phyllodes tumor cell line SYSH-MPT-04, and is deposited under CCTCC NO. C2022190 ...
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WO/2024/047250A1 |
The invention relates to methods for determining the methylation profile of DNA sequences of interest and methods for accurately distinguishing between a healthy methylation profile and a cancerous methylation profile, as well as to kits...
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WO/2024/050023A1 |
The present disclosure relates to the treatment of a cancer in a human subject where the treatment includes continuing administration of a T cell receptor (TCR) therapy in subjects whose ctDNA levels do not exceed baseline following admi...
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WO/2024/050383A2 |
Provided herein are, inter alia, biosensor recombinant proteins (e.g. ratiometric Ras activity reporter (RasAR)), which provide quantitative measurement of Ras activity in living cells with high spatiotemporal resolution. The biosensor r...
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WO/2024/050331A2 |
Described and featured herein are methods to barcode nucleic acids for detection and sequencing, particularly at a single cell level. The methods involve application of a barcode template in a compartment with various targets, including ...
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WO/2024/050500A1 |
Combined administration of a selective glucocorticoid receptor modulator (SGRM; e.g., relacorilant or exicorilant) and a cancer therapeutic (e.g., a taxane or antiandrogen) is useful for identifying elevated cortisol activity in patients...
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WO/2024/050362A2 |
The present disclosure relates to methods and systems suitable for simultaneously amplifying a number of potential targets and then performing a melt detection based on whether or not any amplification is detected for any target nucleic ...
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WO/2023/133359A9 |
The invention, in some aspects, relates to methods and systems comprising long-read sequencing of DNA molecules for identifying target-specific genetic and epigenetic alterations in DNA sequence of interest.
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WO/2024/047004A1 |
The invention relates to a probe comprising a bead, a first binding assembly and a second binding assembly, wherein: – the first binding assembly comprises a first bead-binding portion and a first probe portion, – the second binding ...
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WO/2024/049476A1 |
The present disclosure relates to the treatment of a cancer in a human subject where the treatment includes continuing administration of a T cell receptor (TCR) therapy in subjects whose ctDNA levels do not exceed baseline following admi...
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WO/2024/048440A1 |
Provided is a simple and accurate method for identifying immunological high-risk groups in organ transplantation. A method for acquiring data for identifying immunological high-risk groups in organ transplantation according to an embodim...
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WO/2024/047992A1 |
The purpose of the present invention is to provide a method of designing a primer for amplicon methylation sequence analysis by which primer design success rate can be improved while suppressing primer dimer formation rate to an extremel...
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WO/2024/047022A1 |
The present invention refers to the diagnosis, prognosis and treatment of gastro-entero-pancreatic neuroendocrine tumors (GEP-NET). In particular, it refers to an in vitro method for diagnosing a gastro-entero-pancreatic neuroendocrine t...
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WO/2024/047567A1 |
A method of detecting a microbial or viral infection in a putative host. The method comprises reverse transcribing RNA determinative of the microbial or viral infection into cDNA and amplifying the reverse transcribed cDNA in an assay so...
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WO/2024/048644A1 |
This carrier for delivering a target substance to MUC6 expression-negative cancer tissues contains a molecule having the activity of binding to mannose. The cancer tissues may be MUC6 expression-negative gastric cancer tissues arising fr...
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WO/2024/050039A2 |
The present disclosure relates to methods of pressure-guided hydrodynamic injection, into tissues such as kidney, pancreas, liver, common bile duct, etc., in certain embodiments for delivery of nucleic acids or viral vectors. This includ...
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WO/2024/044854A1 |
This invention provides chronic graft-versus-host disease (cGVHD) biomarker panels for use in diagnostic and risk assignment methods. More particularly, the invention relates to particular combinations of biomarkers for diagnosing cGVHD ...
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WO/2024/050514A2 |
A device, method, and kit are disclosed for use in detecting a target analyte in a sample. The device includes a region having a first zone, into which the sample can be delivered, and a second zone in fluid communication with the first ...
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WO/2024/048919A1 |
Disclosed are: an autophagy regulation method targeting a signaling system, wherein C/EBP-gamma and ATF form dimers under the condition of amino acid deficiency in cells to regulate gene expression related to autophagy regulation; and a ...
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WO/2024/050366A1 |
Described herein are methods, devices, and systems for identifying a subset of a plurality of features, using one or more feature importance metrics, for training and using a homologous repair deficiency (HRD) classification model. Furth...
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WO/2024/046841A1 |
The present invention relates to a method of certifying a test animal-derived product sample, the method comprising the steps of: (a) determining a test methylation profile of one or more pre-selected methylation sites within the genomic...
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WO/2024/048720A1 |
To provide a search method for lipase that is capable of efficiently searching for a lipase that is resistant to activity inhibition by a surfactant and/or exhibits excellent cleaning power in the presence of a surfactant. A search metho...
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