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WO/2023/056350A9 |
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
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WO/2024/077095A1 |
The invention provides methods for classifying bladder cancer (e.g., urothelial cancer (UC), e.g., locally advanced or metastatic UC); methods for treating bladder cancer in a patient, for example, by administering a treatment regimen th...
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WO/2024/077047A1 |
The present disclosure relates in some aspects to methods and compositions for generating modified surfaces for microfluidic device (e.g., flow cells) and for characterizing the surface chemistry of the modified surfaces, such as the rel...
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WO/2024/077162A2 |
Described herein are compositions and methods for enriching library fragments prepared for coronavirus sequences prepared from various samples. These methods may incorporate microfluidics and flowcells for greater ease of use. Libraries ...
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WO/2024/077202A2 |
Described herein are compositions and methods for enriching library fragments comprising viral sequences prepared from a variety of samples. These methods may incorporate microfluidics and flowcells for greater ease of use. Libraries enr...
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WO/2024/075662A1 |
One purpose of the present disclosure is to provide a method for testing for the presence/absence of a stroke.　The method for testing for the presence/absence of a stroke includes a step of measuring the presence/absence of at least on...
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WO/2024/074953A1 |
A method to predict a propensity of an infant to develop atopic dermatitis. The method includes observing the expression of S100A8/A9 on a skin area of an infant; comparing the expression to determined standard, wherein the determined st...
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WO/2024/076723A1 |
Provided herein are methods to harvest EVs (such as increased yields of EVs) from bacterial cultures.
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WO/2024/074806A1 |
The invention relates to a method of determining somatic allele-specific copy number alterations (CNAs) in the genomes of cells in a test-sample from a subject, the method comprising: i) providing an indexed-DNA library of DNA fragments ...
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WO/2024/075844A1 |
The present disclosure provides a technique for examining the acquisition risk of an inflammatory skin disease, the severity or the degree of progression thereof. The present disclosure provides a method for analyzing a biological sample...
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WO/2024/076991A2 |
Disclosed herein, inter alia, are mutant enzymes, kits, and methods of use thereof.
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WO/2024/076908A1 |
The present disclosure relates generally to compositions, methods and systems for characterizing a biological particle, cell or cell nucleus, modified to include an exogenous insert, e.g., exogenous nucleic acids. The characterization ma...
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WO/2024/077111A2 |
An aspect of the present disclosure provides an engineered nucleotide molecule. The engineered nucleotide molecule can comprise a pentose sugar. The engineered nucleotide molecule can comprise a base coupled to the pentose sugar, wherein...
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WO/2024/077096A1 |
This disclosure describes methods, non-transitory computer readable media, and systems that can generate genotype calls from a combined pipeline for processing nucleotide reads from multiple read types/sources for robust, accurate genoty...
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WO/2024/075803A1 |
The present invention addresses the problem of providing: a method for testing a cranial nerve disease including schizophrenia, or a method for testing the sensitivity to a cranial nerve disease; and a reagent and a kit for use in the te...
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WO/2024/075941A1 |
The present invention relates to super absorbent polymer-based surface fixation technology for extracellular vesicles or cells and, more specifically, to a technology and applications thereof, the technology fixing, to the surface of a s...
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WO/2024/077158A1 |
In various aspects and embodiments, the present disclosure provides methods for generating T cell populations for cell therapy, including T lymphocytes (T cells) and progenitor T cells. In various embodiments, the invention provides for ...
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WO/2024/076484A1 |
The present disclosure provides methods for preparation and analysis of biological samples of xenotransplant recipients, wherein the methods comprise extracting fragmented or intact cell-free DNA, RNA (such as mRNA or miRNA), or protein ...
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WO/2024/077114A1 |
The invention provides systems and methods for making sequencing libraries that are useful for quantitatively analyzing nucleic acids in a sample. Sample nucleic acids are randomly cleaved at, and PCR. handled are attached to, a random c...
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WO/2024/077037A1 |
The present disclosure relates to compositions and methods for the detection of 3' UTR somatic mutations and/or variants for use as prognostic assay for response to cancer immunotherapy. The present disclosure allows for the use of one o...
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WO/2024/077185A2 |
A core-shell particle system for performing nucleic acid amplification of targets includes particles having a hydrogel outer shell surrounding a core region that is substantially devoid of hydrogel, wherein the outer shell comprises pore...
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WO/2024/073885A1 |
Provided are a fluid system, a fluid transportation method, a gene sequencer, and a biochemical detection method. The fluid transportation method comprises the following steps: a) using a pump valve assembly to draw a first fluid from a ...
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WO/2024/074912A2 |
A test device for monitoring sterilization using a steam sterilant in a chamber is provided. The test device includes a test stack. The test stack includes an entrance layer including an entrance hole. The test stack further includes a s...
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WO/2024/075004A1 |
The invention relates to methods of identifying a Cannabis spp. plant comprising a quantitative trait locus (QTL) associated with a high CBGA trait, and to Cannabis spp. plants having a high CBGA trait comprising defined allelic states o...
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WO/2024/076996A1 |
Disclosed are an assay, method, and kit for detecting a monkeypox virus (MPXV) and the application thereof. The assay may be used alone or in combination with another assay or assays. The method of using and kit includes a composition us...
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WO/2024/076485A1 |
Systems and methods are provided herein for preparing a non-naturally-occurring preparation of DNA from perfusion fluid or flush, the preparation being useful for assessing transplantation outcomes of a donor organ or donor tissue which ...
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WO/2024/075204A1 |
First, step S101 of this analysis method involves culturing cells on a hydrogel layer comprising a hydrogel, the swollen state of which changes according to the interaction with a substance (chemical species) to be measured (culturing st...
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WO/2024/075637A1 |
Provided are an ionic current measurement method and an ionic current measurement device capable of increasing an S/N ratio of a measurement result of a change in an ionic current. The ionic current measurement device comprises a board h...
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WO/2024/076956A2 |
This disclosure concerns methods and compositions for identifying canola plants that have a low fiber content trait. Some embodiments concern a quantitative trait locus and chromosomal segment deletion which are associated with low fiber...
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WO/2024/077286A2 |
Compositions and methods are described herein that are useful for the detection of prostate cancer progression by determining the expression levels of genes associated with metastatic PCa. Based on the expression of IL-6, SELE, FOSB, NRK...
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WO/2024/077281A2 |
The present disclosure provides in vitro assays for genotyping a porcine reproductive and respiratory syndrome virus (PRRSV). Methods and kits for the in vitro assays are also provided.
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WO/2024/075787A1 |
The present disclosure provides a novel highly efficient method and the like for obtaining a gene sequence. More specifically, the present disclosure provides: a highly efficient method for obtaining a gene sequence in which a nucleic ac...
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WO/2024/077159A1 |
The present disclosure provides for efficient ex vivo processes for generating B cell lineages from human induced pluripotent stem cells (iPSCs). Cells generated according to the disclosure in various embodiments are functional and/or mo...
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WO/2024/076473A1 |
The present disclosure relates to compositions of matter and assay methods used to screen for molecular dimerization events using a two-ribonucleoprotein complex signal boost assay. The compositions and methods provide a readout upon det...
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WO/2024/049915A9 |
Provided herein are computer-implemented methods for assigning maternal or fetal origin to one or more genetic variants in cell free DNA (cfDNA) from a sample from a pregnant mammal, preferably a pregnant human, using a probabilistic mod...
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WO/2024/066317A1 |
Provided is a method for preparing a Chinese actinidia root tissue cell nucleus suitable for single-cell sequencing. The cell nucleus prepared by means of an original lysis solution formula and a cell nucleus suspension optimization meth...
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WO/2024/069614A1 |
Described herein are methods and kits directed to the use of ANGPTL3, ANGPTL4, ANGPTL8 and/or ANGPTL3/8 inhibitors in the field of severe hypertriglyceridemia, particularly to distinguish between complete or partial lipoprotein lipase (L...
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WO/2024/073050A1 |
A biological indicator system (100) for determining the efficacy of a sterilization process is provided. The system includes a radiofrequency identification sensing board (104) having a radiofrequency identification tag, a microcontrolle...
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WO/2024/072006A1 |
The present invention relates to a method for generating a total mRNA-based random sgRNA library through an enzymatic reaction. The method according to the present invention may generate an sgRNA library that may target the entire genome...
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WO/2024/073049A1 |
A method for determining if a spore in a self-contained biological indicator is in a germination phase is provided. The method includes subjecting a self-contained biological indicator to a sterilization process; exposing spores in the s...
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WO/2024/073136A1 |
A method for rapid reconstruction of nucleic acids is described. The method comprises the stochastic reconstruction of nucleic acid by simultaneous reaction of restriction enzymes and a DNA ligase. Copy number variations (CNVs) are almos...
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WO/2024/065376A1 |
Disclosed in the present invention is the use of a differentially methylated region of callipyge gene in meat trait breeding. Disclosed in the present invention is a differentially methylated region from an imprinted region Dlk1-Mirg of ...
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WO/2024/071374A1 |
The present invention addresses the problem of providing: a cell screening method that has excellent screening sensitivity and screening efficiency; a nucleic acid production method for acquiring nucleic acid from cells obtained by the s...
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WO/2024/072890A1 |
Methods and materials involved in reducing the level of a long noncoding RNA of fat mass and obesity-associated protein (FTO-IT1) in a cell are provided herein.
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WO/2024/073714A1 |
This disclosure relates to novel amplification compositions and methods, in particular for use in sequencing.
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WO/2024/065068A1 |
The present invention relates to a set of primers for determining cell identity from a biological sample, said set comprising at least one primer selected from SEQ ID NO. 1 to SEQ ID NO. 70 that amplify the gene sectors selected from rpo...
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WO/2024/069235A2 |
The disclosure provides therapeutic compositions that include theranostic nucleic acid nanostructures for delivery of cargo and methods of using the same.
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WO/2024/072897A1 |
Provided herein are methods, compositions, reaction mixtures, kits and systems for measuring protease activities, detecting protein-protein interactions, and identifying signaling molecules that induce protein-protein interactions. In pa...
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WO/2024/067386A1 |
The present invention provides a culture medium and use thereof in water toxicity colorimetric detection. The culture medium comprises glucose, peptone, NaCl, a beef extract, and a ferric salt. The solubility of the ferric salt in water ...
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WO/2024/072775A1 |
The present disclosure provides devices, systems, kits, and related methods for isolating DNA from a sample (e.g., plasma) using RNA-guided DNA binding proteins (e.g., Cas proteins). Particularly, the disclosure provides devices, systems...
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