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WO/2024/100545A1 |
The present invention proposes novel derivatives of phthalazinium dicyanomethanides (I), a process for manufacturing same, and the use thereof in the functionalization of peptides and proteins, in the attachment of biological polymers to...
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WO/2024/102996A1 |
Systems, methods, and compositions can be used to generate a therapeutic cell. The system can be an fully closed, automated system. The system, methods and compositions can intake cells of a subject and modify the cells to generate thera...
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WO/2024/103044A1 |
Compositions and methods involving Bacteroides ovatus are provided herein in certain aspects to reduced GVHD, including GVHD associated with Bacteroides thetaiotaomicron. This includes therapeutic compositions comprising the bacteria Bac...
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WO/2024/098185A1 |
Methods and kits for sequencing a nucleic acid molecule are provided, which include utilizing four different compounds that are respectively derivatives of nucleotides A, (T/U), C and G, wherein the hydroxyl at the 3'-position of sugar o...
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WO/2024/098116A1 |
The present invention relates to CRISPR/Cas-based biosensing materials, assays and methods. In particular, the technology relates to ultrasensitive CRISPR/Cas-based detection methods for nucleic acid assays using special molecular constr...
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WO/2024/098146A1 |
Provided herein are an a2-3 disialylated PSA protein standard and an a2-6 disialylated PSA protein standard, as well as various methods for measuring the relative (fractional) amount of the total N-acetylneuraminic acid (Neu5Ac) that is ...
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WO/2024/100258A1 |
The present invention relates to a library comprising a plurality of detection probes suitable for detection of a set of analytes of interest, each detection probe comprising an analyte-specific binding domain and a nucleic acid moiety, ...
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WO/2024/098295A1 |
The present invention provides a digital PCR method for an integrated micro-droplet chip, which belongs to the technical field of digital PCR analyzers. The method comprises: controlling a sample adding cavity and a gas-liquid interface ...
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WO/2024/101294A1 |
[Problem] To provide a method for obtaining a sequence for a nucleic acid including an artificial nucleic acid, more specifically a method for amplifying a sequence for a nucleic acid including a non-cyclic artificial nucleic acid to amp...
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WO/2024/102761A1 |
Provided herein are methods of detecting tumor nucleic acids in a biological sample of a subject.
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WO/2024/100070A1 |
The invention relates to the field of molecular biology and more particularly that of clinical and industrial microbiology. More specifically, the present invention relates to a culture medium for detecting microorganisms, comprising, as...
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WO/2024/101758A1 |
The present invention relates to a novel nucleic acid isothermal amplification method using extension-mediated self-folding. Specifically, the present invention relates to a primer set for extension-mediated self-folding isothermal ampli...
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WO/2024/098369A1 |
Disclosed herein are an isolated microRNA molecule, a Parkinson's disease in-vitro diagnostic kit based on a DNA hexahedron, and use thereof. The microRNA molecule miR26690 provided by the present application is highly expressed in an ex...
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WO/2024/102484A1 |
The disclosed technology relates to methods for improved risk stratification of Acute Myeloid Leukemia (AML.) patients, and more particularly, for improved risk stratification of adult and pediatric AML patients using inflammation gene s...
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WO/2024/101323A1 |
The present disclosure pertains to a method for producing a cell population, the method comprising: a step for separating cells from a three-dimensional tissue body formed in vitro and containing the cells and an extracellular matrix com...
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WO/2024/102839A1 |
Compositions, assays, methods, diagnostic methods, kits, and diagnostic kits are disclosed for the specific and differential detection of SARS-CoV-2, Flu A, Flu B, RSV A, and RSV B from samples, including veterinary samples, clinical sam...
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WO/2024/101823A1 |
The present invention relates to a biomarker for predicting immunotherapeutic responsiveness based on spatial transcriptome analysis and uses thereof and, in particular, to: a marker composition for predicting the responsiveness of cance...
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WO/2024/099592A1 |
The present invention relates to a spinach plant that is resistant to downy mildew caused by Peronospora farinosa. The present invention further relates to a resistance gene that confers resistance to downy mildew in spinach plants and m...
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WO/2024/099816A1 |
The present invention relates to a method of determining complement activity, wherein said method comprises determining classical complement pathway activity, determining alternative complement pathway activity, and/or determining lectin...
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WO/2024/102913A1 |
The present disclosure provides methods of treating a subject having a kidney disease or preventing a subject from developing a kidney disease by administering an Angiopoietin Like 3 (ANGPTL3) inhibitor and a Solute Carrier Family 5 Memb...
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WO/2024/102360A1 |
Devices for isolating, collecting and/or transferring target molecules to an assay area, comprising an enclosure having a top section adapted to receive a sample, a central hollow body section or other area or cavity suitable for receivi...
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WO/2024/050331A3 |
Described and featured herein are methods to barcode nucleic acids for detection and sequencing, particularly at a single cell level. The methods involve application of a barcode template in a compartment with various targets, including ...
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WO/2024/097970A1 |
Methods and materials for improving outcomes for ex vivo perfused organs are provided herein. For example, this document provides methods and materials that can be used to assess and treat lungs during ex vivo perfusion prior to transpla...
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WO/2024/059528A3 |
The digital amplification methods and kits provide the ability to estimate the fetal fraction of cell-free DNA (cfDNA) in a maternal sample, e.g., plasma or serum, by analysis of target sites that are differentially methylated in fetal a...
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WO/2024/093522A1 |
The present disclosure relates to methods, compositions, and kits for concentrating and purifying one or more target analyte (s) from a bulk fluid sample. In some embodiments, the methods involve at least two first aqueous two-phase syst...
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WO/2024/095238A1 |
Provided is a magnetosome comprising a doped mineral. Further provided is method for large-scale production of magnetosomes comprising a doped mineral, the method comprising maintaining in a fermentation vessel under continuous fermentat...
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WO/2024/097899A1 |
Polynucleotides, expression constructs, compositions, kits and method relating to genetic disorders are disclosed. Some embodiments provided herein encompass variants of a protein that relate to a genetic disorder. Also contemplated are ...
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WO/2024/059581A3 |
The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the ...
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WO/2024/092740A1 |
Provided is a method for detecting intercellular interaction. The method comprises: (1) preparing a first cell expressing a TCR activation response element and a reporter molecule, the first cell expressing a TCR; (2) co-incubating an an...
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WO/2024/036319A3 |
A system for detecting multiple target polynucleotides in a sample, comprising: a RNA-guided nuclease; a plurality of guide molecules, each comprising a sequence capable of binding a target polynucleotide in the sample; and a plurality o...
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WO/2024/093523A1 |
The present disclosure relates to methods, compositions, and kits for isolating target nucleic acids below a target size from a sample comprising nucleic acid components. In some embodiments, the methods involve one or more aqueous two-p...
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WO/2024/096125A1 |
The present disclosure provides a technique for efficiently designing or producing a bacterial preparation utilizing a bacterium capable of exhibiting a desired trait or a desired efficacy. More specifically, the present disclosure provi...
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WO/2024/095564A1 |
Provided is a method for estimating the metabolic flux distribution of cells, the method comprising: a step for acquiring discharge data including time-series data of a substance discharged to the outside of the cells with respect to a f...
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WO/2024/059719A3 |
The present invention provides optimized template switching oligonucleotides, methods, and kits for performing reverse transcription. The optimized template switching oligonucleotides include modifications of the 5' and 3' ends to preven...
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WO/2024/095262A1 |
An interlaced (in silico/in vitro) pipeline for rapid and efficient selection of primer sets for use in multiplex PCR reactions; reagents comprising primer sets for use in multiplex PCR reactions identified by the interlaced pipeline, an...
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WO/2024/050519A3 |
The present disclosure relates to the use of exosomal proteins to identify, diagnose, treat, and/or prevent ovarian cancer.
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WO/2024/097838A2 |
Provided herein according to some aspects is a method for processing a tissue sample from a subject, the sample comprising cells of a breast tissue site comprising or suspected of comprising ductal carcinoma in situ (DCIS), and detecting...
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WO/2024/094966A1 |
A method of controlling a biochemical analysis system for analysing polymers comprising a sequence of polymer units is provided. The system is operable to take successive measurements of a polymer from a sensor element during translocati...
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WO/2024/093519A1 |
The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase syste...
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WO/2024/097900A1 |
RNA molecules comprising a guide sequence portion having 17-50 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-2325 and compositions, methods, and uses thereof.
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WO/2024/097357A1 |
Described herein is a method of extracting and quantitating low density lipoprotein cholesterol (LDL-C) in a blood sample. The sample is first diluted or rehydrated in a reagent 1 to provide a diluted sample. The diluted sample is then m...
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WO/2024/092358A1 |
There is described herein a method of prognosing or classifying a subject with a Myeloproliferative Neoplasm (MPN) comprising: (a) determining the expression level of at least 10 genes in a test sample from the subject selected from the ...
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WO/2024/097744A2 |
The present invention provides methods of generating diverse chemical structures on DNA through Wittig olefination of novel on-DNA phosphorane ylides and Homer- Wadsworth-Emmons reaction of on-DNA β-keto phosphonates. The methods of thi...
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WO/2024/095161A1 |
The present disclosure describes methods for analyzing mRNA poly(A) tail sequences with a high resolution to determine poly (A) tail length and heterogeneity. The method involves digesting an mRNA molecule to liberate a poly(A) tail, pre...
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WO/2024/094858A1 |
The present invention relates to diagnosis of tuberculosis in saliva. In particular, the present invention relates to a method for determining whether a subject is likely to be infected with Mycobacterium tuberculosis (mt) by incubating ...
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WO/2024/097892A1 |
This disclosure relates to introducing specified endogenous amiRNA responsive to endogenous primary-miRNAs. This invention allows the degradation of amiRNAs in specific tissues, while allowing amiRNA to silence gene expression in other t...
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WO/2024/096354A1 |
The present invention relates to a pharmaceutical composition for preventing or treating kidney cancer comprising an IFITM3 inhibitor. According to a composition according to one aspect, the tumorigenesis inhibitory effect can be induced...
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WO/2024/094793A1 |
The present invention relates to the purification of linear DNA products, which may have nuclease-resistance. The linear DNA products may be double-stranded or single stranded. In addition, the present invention relates to purified linea...
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WO/2024/097373A1 |
Provided herein are methods and compositions relating to the use of single cell RNA sequencing to assess gene editing outcomes in transplanted populations of gene edited hematopoietic stem cells.
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WO/2024/096149A1 |
The embodiment provides a microbial analysis device comprising: an input part that receives a set of NGS analysis files for a target environment from an external NGS server; a preprocessing part that reads a forward read file and a rever...
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