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WO/2024/097744A2 |
The present invention provides methods of generating diverse chemical structures on DNA through Wittig olefination of novel on-DNA phosphorane ylides and Homer- Wadsworth-Emmons reaction of on-DNA β-keto phosphonates. The methods of thi...
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WO/2024/095161A1 |
The present disclosure describes methods for analyzing mRNA poly(A) tail sequences with a high resolution to determine poly (A) tail length and heterogeneity. The method involves digesting an mRNA molecule to liberate a poly(A) tail, pre...
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WO/2024/094858A1 |
The present invention relates to diagnosis of tuberculosis in saliva. In particular, the present invention relates to a method for determining whether a subject is likely to be infected with Mycobacterium tuberculosis (mt) by incubating ...
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WO/2024/097892A1 |
This disclosure relates to introducing specified endogenous amiRNA responsive to endogenous primary-miRNAs. This invention allows the degradation of amiRNAs in specific tissues, while allowing amiRNA to silence gene expression in other t...
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WO/2024/096354A1 |
The present invention relates to a pharmaceutical composition for preventing or treating kidney cancer comprising an IFITM3 inhibitor. According to a composition according to one aspect, the tumorigenesis inhibitory effect can be induced...
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WO/2024/094793A1 |
The present invention relates to the purification of linear DNA products, which may have nuclease-resistance. The linear DNA products may be double-stranded or single stranded. In addition, the present invention relates to purified linea...
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WO/2024/097373A1 |
Provided herein are methods and compositions relating to the use of single cell RNA sequencing to assess gene editing outcomes in transplanted populations of gene edited hematopoietic stem cells.
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WO/2024/096149A1 |
The embodiment provides a microbial analysis device comprising: an input part that receives a set of NGS analysis files for a target environment from an external NGS server; a preprocessing part that reads a forward read file and a rever...
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WO/2024/097856A1 |
The present disclosure is based on the identification of copy number of DPP9 gene and expression of a set of genes as biomarkers predictive of responsiveness to DPP inhibitors, particularly Talabostat or a pharmaceutically acceptable sal...
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WO/2024/097936A2 |
The present disclosure provides methods to detect a target in a sample by using a DNA scaffold with enzymatic activity ("DNAzyme") that catalyzes hydrogen peroxidase decomposition, leading to a reaction wherein bubbles are produced. In p...
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WO/2024/097257A1 |
Methods and compositions for monitoring mutation burden, cancer status, vaccine efficacy using cell-free DNA sequencing following enrichment with combination probe panels are disclosed.
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WO/2024/093421A1 |
Provided are a surface treatment method, a sequencing method, and a kit for nucleic acid molecule extension. The surface treatment method comprises: contacting a phosphate compound with a surface bound with an oligonucleotide, wherein th...
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WO/2024/096120A1 |
The present disclosure relates to improving the colonization properties of a bacterial preparation in a host. Specifically, the present disclosure relates to a microorganism wherein at least one gene is modified, said modification improv...
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WO/2024/092713A1 |
Disclosed in the present invention is an MMLV reverse transcriptase mutant. Compared with the amino acid sequence of wild-type MMLV reverse transcriptase, the MMLV reverse transcriptase mutant provided in the present invention has mutati...
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WO/2024/096618A1 |
The present invention relates to a cancer risk prediction method and a composition thereof. The present invention was confirmed to be far superior to existing known SNP set combinations with respect to cancer risk prediction for Asian ca...
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WO/2024/094708A1 |
The present invention relates to a three-dimensional polynucleotide-based open shells for encapsulating a virus or viral particle, to a composition comprising a mixture of such three-dimensional polynucleotide-based open shells, to a com...
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WO/2024/095599A1 |
Provided is a method for producing glomus cell-like cells, the method including: (a) a step for inducing differentiation of pluripotent stem cells into autonomic progenitor cells; and (b) a step for culturing the autonomic progenitor cel...
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WO/2023/177526A9 |
The disclosure provides nucleic acid molecules (comprising expression cassettes), plasmids, protein molecules, cells (comprising nucleic acid molecules), and recombinant expression systems for producing recombinant cascade reagents for t...
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WO/2024/094817A1 |
The present invention relates to a score (TOPOSCORE) for describing eubiosis or dysbiosis in an individual, that can be used, inter alia, for determining if a patient is likely to respond to an immune-oncology treatment, more precisely, ...
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WO/2024/097758A1 |
Provided herein are methods of treating acute leukemia, such as acute myeloid leukemia (AML), in an individual, such as an individual having a mutation within the nucleophosmin 1 (NPM1) gene or a rearrangement within the lysine[K]-methyl...
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WO/2024/097263A1 |
Systems, methods, compositions, and kits for measuring secreted analytes from cells are disclosed herein, including those capable of determining single cell secretion activity and protein expression and/or gene expression simultaneously....
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WO/2024/097893A2 |
Disclosed herein are fusion proteins and systems for detection of protein secretion. Also disclosed herein are methods for identifying at least one genomic region in a cell that modulates the secretion of a protein and methods for detect...
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WO/2024/092768A1 |
The present invention relates to a thermostable reverse transcriptase and use thereof. The thermostable reverse transcriptase has at least one of mutation positions L333, P65, Q68, P127, P175, E176, G178, G331, T332, F334, and G105, wher...
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WO/2024/094578A1 |
The present invention is directed to seedless fruit producing melon. The present invention also comprises methods for production of said plants and methods for producing seedless melon. Plants and plant parts of the invention comprise at...
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WO/2024/098076A1 |
Aspects of the present disclosure relate generally to methods, compositions, and kits for conjugating cells with magnetic beads. Aspects of the present disclosure also include methods, compositions, and kits for using magnetic bead conju...
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WO/2024/096642A1 |
The present invention relates to a DNA aptamer for the diagnosis of colorectal cancer and, specifically, to a composition and a kit for the diagnosis of colorectal cancer, and a colorectal cancer-specific drug delivery composition, each ...
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WO/2024/096467A1 |
The present invention relates to a marker for predicting the prognosis of colon cancer by using normal tissues adjacent to tumors. The marker for predicting the prognosis of colon cancer by using normal tissues adjacent to tumors and a k...
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WO/2024/096538A1 |
The present invention relates to a DNA methylation marker for diagnosing liver cancer and uses thereof and, more specifically, to a combination of DNA methylation markers that can determine the presence of liver cancer and uses thereof. ...
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WO/2024/097571A1 |
Disclosed are compositions and methods for using heme and at least one PAMP and/or DAMP molecule for activating NLRP12 and/or NLRC5 and inflammatory cell death. Also provided is a screening assay for identifying NLRP12 and/or NLRC5 inhib...
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WO/2024/097392A1 |
Provided herein are compositions and methods useful for the detection of Herpes Simplex Virus 1 (HSV-1), Herpes Simplex Virus 2 (HSV-2) and Varicella Zoster Virus (VZV). In particular, provided herein are compositions, methods, systems, ...
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WO/2024/097262A1 |
Methods of identifying RNA-binding sites in proteins are described. In some embodiments, the methods utilize clickable electrophilic purines (CEPs) to study protein-RNA interactions on proteins through photoaffinity competition with 4-th...
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WO/2024/097798A1 |
The present invention provides anti-TREM2 antibodies, formulations thereof, and methods of use thereof.
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WO/2024/096937A1 |
Affinity reagents are described, including antibodies and aptamers that are cross- reactive with one or more A. ocellatum or P. pillulare antigens. The aptamers and antibodies can detect these antigens in marine organisms or aquaculture ...
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WO/2024/094986A1 |
Provided herein are methods of characterising a target polypeptide as it moves with respect to a nanopore. Also provided are related kits, systems and apparatuses for carrying out such methods.
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WO/2024/097941A1 |
A method of treating malignancy in a subject in need thereof is provided. The method includes administering a therapeutically effective amount of a compound that increases the level of one or more of piR_017723, piR_23656, or piR_016745,...
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WO/2024/096484A1 |
The present invention relates to a biomarker for detecting food poisoning bacteria by using next-generation sequencing, and a method for detecting food poisoning bacteria by using same. Specifically, a biomarker composition according to ...
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WO/2024/096856A1 |
The invention provides methods for synthesizing a product DNA molecule of any DNA sequence from a universal library of overlapping oligonucleotides. The method involves combining a plurality of the overlapping oligonucleotides in a react...
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WO/2024/097640A2 |
Proteins having luciferase activity, nucleic acids encoding such proteins, and methods for their use are provided, wherein the proteins have a secondary' structure arrangement H1- L1-H2-L2-E1-L3-E2-L4-H3-L5-E3-L6-E4-L7-E5-L8-E6, where "H...
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WO/2024/097702A2 |
Devices, methods and test kits for the detection of Human Immunodeficiency Virus Type (HIV) infection are disclosed. The methods comprise the use of single use, qualitative, manually performed, visually read, in vitro immunoassays for th...
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WO/2024/097981A1 |
Disclosed are methods for the diagnosing and staging of cancers including, but not limited to multiple myeloma and treatment regimens incorporating said methods.
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WO/2024/092712A1 |
Disclosed is an MMLV reverse transcriptase mutant. The present invention provides an MMLV reverse transcriptase mutant having mutations at amino acid residue positions 66 and 68 compared with the wild-type MMLV reverse transcriptase amin...
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WO/2024/092942A1 |
Disclosed are a biomarker for tuberous sclerosis complex-no mutation identified (TSC-NMI) and use thereof. The biomarker is an expression level of an IQGAP2 gene. The IQGAP2 gene can be used as a detection marker of TSC-NMI, and has the ...
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WO/2024/092562A1 |
Provided is a blocking sequence, a kit thereof, and a method for using same. The blocking sequence comprises a blocking sequence 1, a blocking sequence 2, a blocking sequence 3, and a blocking sequence 4. The blocking sequence 1 is compl...
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WO/2024/095017A1 |
The invention relates to methods for assessing the risk of pregnancy loss or embryo implantation failure, and also for monitoring or evaluating the effect of a treatment to reduce the risk of pregnancy loss or embryo implantation failure...
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WO/2024/095188A2 |
The present disclosure relates to landing pads, proviruses and methods of use thereof.
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WO/2024/098073A1 |
Methods for liver cancer detection use a combination of genome-wide mutation and fragmentation features of cfDNA that facilitate cancer screening.
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WO/2024/096119A1 |
The present disclosure relates to providing an oral environment model of a subject, or a medium representing that model. More specifically, the present disclosure relates to a medium for culturing oral indicator bacteria using oral compo...
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WO/2024/093681A1 |
Provided is use of infigratinib or a pharmaceutically acceptable salt thereof in preparing a medicament for treating and/or preventing gastric cancer or gastroesophageal junction adenocarcinoma, in particular, locally advanced or recurre...
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WO/2024/096318A1 |
The present disclosure provides a method for isolating an exosome with increased exosome isolation efficiency, and a cosmetic composition comprising an exosome having improved wrinkle amelioration, cell proliferation, wound healing, or w...
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WO/2024/097138A1 |
Alternative splicing events in genes can lead to non-productive mRNA transcripts which in turn can lead to aberrant or reduced protein expression, and therapeutic agents which can target the alternative splicing events in the genes can m...
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