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WO/2024/059516A1 |
Disclosed herein are compositions and methods related to the fast and efficient generation of cDNA library from RNA. The method allows integration of the method in an automation adaptable system.
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WO/2024/058178A1 |
The present invention provides a reagent that is for measuring an epidermal growth factor receptor tyrosine kinase activity and that contains: a modified polypeptide to which an acceptor and a donor inducing Förster resonance energy tra...
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WO/2024/057091A1 |
The present invention relates to hybrid barley seed production and marker assisted selection of barley plants in order to obtain barley plants or seeds comprising an Ant1 and/or Ant2 gene allowing color sorting of seeds.
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WO/2024/059180A1 |
Phenotypic screening methods that can be used for the screening of nitrogen fixation activity in bacteria are described herein. Such screening methods utilize a plurality of partitions comprising soil that allow for cost effective and ef...
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WO/2024/059494A1 |
Provided herein are methods of treating multiple myeloma, including multiple myeloma that is resistant to at least one therapeutic agent, comprising administering to a subject with multiple myeloma an inhibitor of Ubiquitin-Like with PHD...
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WO/2024/057007A1 |
Reusable flow cells for sequencing which exhibit signal intensity retention over numerous use cycles, the active surface of which contains poly-azide functional moieties, methods of treating flow cells surfaces with reagents to provide s...
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WO/2024/057031A1 |
The present invention is directed to cell-free methods, such as those for determining the clostridial neurotoxin activity of a composition, determining whether or not a composition comprises clostridial neurotoxin polypeptides, and/or de...
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WO/2024/055627A1 |
The present application provides a primer-molecular beacon combination for molecular typing of a wild type and a mutant type of a monkey poxvirus and use thereof. The primer-molecular beacon combination comprises a primer pair and a mole...
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WO/2024/059788A2 |
Provided is a method for labeling a nucleic acid, including providing a target nucleic acid to be labeled; providing a 5'-end glycosylase to react with the target nucleic acid to create an intermediate nucleic acid having an abasic site ...
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WO/2024/058252A1 |
A method according to the present invention is a method for predicting the therapeutic effect of pharmacotherapy in the treatment of a subject with metastatic prostate cancer, wherein the pharmacotherapy includes at least one selected fr...
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WO/2024/059719A2 |
The present invention provides optimized template switching oligonucleotides, methods, and kits for performing reverse transcription. The optimized template switching oligonucleotides include modifications of the 5' and 3' ends to preven...
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WO/2024/056038A1 |
The present invention belongs to the field of genetic engineering and provides a modified CaPif1 helicase, a complex comprising the helicase, a construct comprising the helicase, a method for using the helicase or the complex or the cons...
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WO/2024/058869A1 |
Systems, methods, and computer-readable storage media for comparing genetic data of at least two individuals to determine a relationship between the at least two individuals and to present the relationship while providing privacy protect...
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WO/2024/059748A1 |
The present disclosure relates to an HCR lateral flow device for amplified detection of a target in a sample and methods of using the same. In some embodiments, the device and methods of use combine the sensitivity of HCR signal amplific...
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WO/2024/055149A1 |
A sequencing method for a semiconductor sequencing chip, a data processing system, and a gene sequencing system. The semiconductor sequencing chip comprises a plurality of core rows formed by arranging a plurality of cores. The sequencin...
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WO/2024/055406A1 |
The present invention provides a soybean saponin-related KASP marker and use thereof, and belongs to the technical field of molecular breeding. The KASP marker comprises one or two of S07_43139773G/T and SO7_43139033A/G. The S07_43139773...
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WO/2024/057327A1 |
A polynucleotide encoding a chimeric polypeptide comprising an amino acid sequence of a ligand capable of binding a cancer-associated receptor is provided. The amino acid sequence of the ligand being translationally fused to a heterologo...
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WO/2024/059197A1 |
The present disclosure relates to methods, compositions, and kits for providing cleaved, single-stranded nucleic acids. Such nucleic acids can be used to provide ladder compositions.
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WO/2024/055405A1 |
The present invention provides a soybean oligosaccharide-related KASP marker and use thereof and belongs to the technical field of molecular breeding. The KASP marker comprises one or two of S18_51868868T/G and S10_38081012T/C. The S18_5...
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WO/2024/058850A1 |
The present disclosure provides technologies for efficient, sensitive, and/or accurate separation and/or isolation of subpopulations of cells, including rare cells, and methods of detecting of the presence or absence of genetic variants ...
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WO/2024/056853A1 |
The present invention relates to the use of coumarin derivatives as tools for the in vitro or ex vivo diagnosis of bacterial efflux, a method for the in vitro or ex vivo diagnosis of bacterial resistance by efflux, as well as specific co...
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WO/2024/058335A1 |
The present application relates to biomarkers for measuring anticancer drug resistance, including genes expressed in cancer cell groups, wherein the genes cause anticancer drugs, having permeated into the cancer cell groups, to be discha...
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WO/2023/230308A9 |
The present disclosure provides compounds of the formulae herein (e.g., Formulae (I) or (II)), and pharmaceutically acceptable salts thereof, which are degrader compounds of Quiescin Sulfhydryl Oxidase 1 (QSOX1) mRNA. The present disclos...
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WO/2024/059649A1 |
Provided herein is a DNA methylation signature of retinoblastoma and methods of use.
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WO/2024/058300A1 |
The present invention relates to a composition for detecting the infection of viral hemorrhagic septicemia virus (VHSV), a kit comprising the composition, and a method for diagnosing the infection of VHSV using same. Specifically, the pr...
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WO/2024/058111A1 |
The present invention provides a method or the like for efficiently screening candidate substances for a hexanal-odor suppressing material. A screening method according to the present invention comprises: adding a test substance and hexa...
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WO/2024/055320A1 |
A gene sequencing method, apparatus and device, and a medium. The method comprises: acquiring a gene sample to be detected and a preset read length; determining a sample type to which each sample contained in the gene sample belongs; for...
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WO/2024/059501A1 |
The present disclosure provide for methods of detecting Mayaro virus in a sample, assays for the detection of the Mayaro virus, and Mayaro virus-specific primers. An assay of the present disclosure can include Mayaro virus (MAYV)-specifi...
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WO/2024/059841A2 |
The present features methods and components for analyte detection in general, methods and components for quantifying analytes associated with bladder cancer, and treatment of patients identified as having analyte levels predictive of bla...
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WO/2023/010046A9 |
Methods are described for cell-type mapping utilizing direct measurement of low-dimensional representation of single-cell transcriptomics with a supervised machine learning algorithm to spatially map cell types, bypassing the need to mea...
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WO/2024/059037A2 |
A method of positively detecting a target pathogen/molecule within a fluid sample and related test devices are described. The device includes a plurality of chambers in adjacent, spaced-apart relationship, and a plurality of isolation va...
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WO/2024/059493A1 |
A method for assaying putative Psilocybe spores, Psilocybe tissue, or a cultured host organism that expresses Psilocybe genes comprises obtaining a sample including nucleic acids, contacting the sample with primers for amplifying target ...
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WO/2024/055605A1 |
The present invention relates to a molecular detection system and a detection method therefor. During an actual detection operation, firstly, a pushing module is controlled to move in a first direction to a loading station, and a kit is ...
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WO/2024/059756A1 |
Heart failure WITH Preserved Ejection Fraction (HFpEF) effects approximately three million people in the United States.
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WO/2024/058750A1 |
The present invention relates to a real-time polymerase chain reaction method with quantitative characteristic and where arrangements are made for realizing high-efficiency detection of fusion type mutations, which is one of the genomic ...
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WO/2024/055928A1 |
An anti-monkeypox virus antibody or an antigen binding fragment thereof, and a reagent and kit for detecting monkeypox virus, which relate to the field of antibodies. The anti-monkeypox virus antibody comprises a heavy-chain complementar...
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WO/2024/056635A1 |
The invention relates to a method of qualitative control of at least one specific property of at least one stem cell, especially to a method of quality control for the pluripotency of pluripotent stem cells (PSCs). The invention further ...
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WO/2024/056560A1 |
The present invention relates to a recombinant expression vector encoding an inducible cell death switch, a pH-stable fluorophore and a pH-sensitive fluorophore. Moreover, the invention relates to cells comprising said recombinant expres...
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WO/2024/059514A1 |
Described herein are methods, compositions, and systems useful for detecting transplant rejection and associated abnormal conditions in solid organ transplant recipients, such as pancreatic transplant recipients, pancreatic and kidney tr...
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WO/2024/058008A1 |
Provided is an oligonucleotide measurement method that is simpler and has higher sensitivity and superior specificity and quantitative properties compared with conventional measurement methods. Also provided is an oligonucleotide measure...
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WO/2024/059550A1 |
The present disclosure provides compositions comprising nucleic acid double-stranded splint adaptors, including kits, and methods that employ the double-stranded splint adaptors. The double-stranded splint adaptors (200) can be used in a...
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WO/2024/059528A2 |
The digital amplification methods and kits provide the ability to estimate the fetal fraction of cell-free DNA (cfDNA) in a maternal sample, e.g., plasma or serum, by analysis of target sites that are differentially methylated in fetal a...
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WO/2024/059097A1 |
An apparatus for generating personalized risk assessments for neurodegenerative diseases includes a computing device that receives user data containing genetic and medical information. It processes the data to create genotype identificat...
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WO/2024/059681A2 |
Disclosed herein are compositions and method for identifying genes that improve or enhance pathogen resistance. Compositions comprising effector polypeptides encoded by the polynucleotides disclosed herein are useful in identifying genes...
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WO/2024/059581A2 |
The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the ...
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WO/2024/059153A2 |
The current disclosure provides an improved sensitivity assay for detecting and quantifying nucleic acids in a sample. The assay utilizes target recycling amplification process (TRAP) for the digital detection of nucleic acids in tandem ...
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WO/2024/057280A1 |
The present disclosure relates to a nanoparticle including a first layer including a first polymer and a first plurality of accessory oligonucleotides, a second layer including a second polymer and a single template site for bonding a te...
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WO/2024/059839A2 |
This disclosure contemplates methods of detecting, measuring, and/or quantifying a tensional force on cells that express an antigen. In certain embodiments, this disclosure relates to methods and devices disclosed herein used to determin...
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WO/2024/058680A1 |
The first subject of the invention is a set of primers for amplifying the nucleotide sequence of the RSVA N gene. The second subject of the invention is a set of primers for amplifying the nucleotide sequence of the RSVB N gene. The thir...
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WO/2024/055843A1 |
A method for detecting novel coronavirus on the basis of receptor binding. The method comprises: using cross-linked agarose as a matrix, and performing surface modification with carboxyl on same to then obtain magnetic agarose microspher...
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