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WO/2024/073730A2 |
Aspects of the present disclosure are directed to methods and systems for sample collection, tRNA sequencing, and diagnosis, prognosis, and treatment of viral infections such as SARS-CoV-2. Disclosed herein are methods for tRNA sequencin...
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WO/2024/071848A1 |
The present invention relates to a screening method for a therapeutic agent for vascular calcification, in which it was confirmed that, in a CaBP9K-deletion model among vascular-calcification-induced animal models, vascular calcification...
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WO/2024/073128A1 |
Disclosed herein is a microfiltration device comprising a microfilter coated with a positively charged degradable layer and a method of preparing the microfiltration device. In particular, the positively charged degradable layer comprise...
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WO/2024/067644A1 |
A method for cell-free preparation of an mRNA transcription template, the method comprising the following steps: 1) in the presence of at least one type of primer and while promoting the amplification of a DNA template, causing contact o...
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WO/2024/073047A1 |
The present disclosure is concerned with proteins, methods, compositions, and kits for mapping of methylation status of nucleic acids. In one embodiment, proteins are provided that selectively act on certain modified cytosines of target ...
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WO/2024/072241A1 |
The invention relates to a novel chemical compound - a diagnostic marker for use in medicine, more specifically in cancer diagnosis, in particular the diagnosis of ovarian cancer. The invention also relates to an in vitro method for dete...
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WO/2024/069464A1 |
The present invention discloses a method to quantify tRNA abundance and tRNA modifications in an RNA sample that comprises contacting RNA with oligonucleotides in the presence of a ligating agent and performing nanopore direct sequencing...
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WO/2024/065721A1 |
Methods are provided for determining a transcription factor binding site on genomic double stranded (ds) DNA of a eukaryotic cell or cells by contacting the genomic dsDNA with a dsDNA deaminase under conditions to convert cytosine of the...
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WO/2024/073014A1 |
A method for detecting multiple pathogens is provided. The method involves linking multiple pathogens to fluorophores and then obtaining emission spectra of the pathogens using a prism- based fluorescence imaging system. In one embodimen...
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WO/2024/073663A1 |
This disclosure relates to novel amplification compositions and methods, in particular for use in sequencing.
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WO/2024/065646A1 |
Provided are a biochip automatic control method and an automatic control system therefor. The automatic control method comprises aspirating a reagent by means of a pipetting mechanism with a suction component, and adding the reagent to a...
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WO/2024/068754A1 |
The invention relates to a system (1) for continuous manufacture of biomolecules comprising feed tanks (2) suitable for storing products and a reaction chamber (4) designed to be fed with products from said feed tanks which form in the r...
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WO/2024/069168A1 |
A method of selective DNA amplification of a DNA mixture comprising a first population of DNA and a second population of DNA, wherein: - a) a catalytically dead Staphylococcus aureus Cas9 complex (dSaCas9) comprising a dSaCas9 protein or...
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WO/2024/073506A1 |
An example of a nucleic acid sequencing component includes a support. A glycolipid bi-layer is attached to at least a portion of the support. First and second primers are respectively attached to the glycolipid bi-layer. In one example, ...
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WO/2024/073740A2 |
The present disclosure provides methods, kits, compositions, devices, and systems for detecting a target nucleic acid, such as a viral RNA. In one aspect, described herein are methods of detecting the target nucleic acid. In other aspect...
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WO/2024/065029A1 |
A laboratory apparatus for research of a microbial community comprising: a receiver plate with a well; an insert plate for securing over the receiver plate, the insert plate including a plurality of tubes extending from the lower surface...
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WO/2024/072122A1 |
The present invention relates to a digital real-time PCR analysis method, and the purpose of the present invention is to provide a digital real-time PCR analysis method capable of digital real-time PCR analysis of a low-concentration or ...
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WO/2024/072922A1 |
An apparatus includes a flow cell, an imaging assembly, and a processor. The flow cell includes a channel and a plurality of reaction sites. The imaging assembly is operable to receive light emitted from the reaction sites in response to...
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WO/2024/073442A1 |
Disclosed are methods for isolating full-length intercellular proteins from a complex, multicellular environment. The disclosed methods include growing cells in the complex environment in the presence of an amino acid or alkanoic acid an...
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WO/2024/065983A1 |
Provided is a method for screening preimplantation embryos. The screening method comprises the following steps: detecting the chromosomes and DNA methylation levels of preimplantation embryos, and screening out embryos in which the chrom...
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WO/2024/069938A1 |
The present invention pertains to a reaction vessel for nucleic acid amplification, wherein the surface roughness Ra of the inner surface of the reaction vessel is 25 nm or less, and to a cartridge (10) for nucleic acid amplification, sa...
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WO/2024/070185A1 |
[Problem] To provide a biomarker which is usable for determining the onset risk of acne. [Solution] One aspect of the present invention provides a biomarker which is usable for determining the onset risk of acne. The biomarker is type II...
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WO/2024/066083A1 |
The present invention relates to the technical field of biology, and in particular to a constant-temperature detection kit and detection method for detecting pathogens. The kit comprises an amplification system; the amplification system ...
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WO/2024/070655A1 |
In this classification method, first, a three-dimensional embryonic image (D2) is acquired by optical coherence tomography. Then, in the three-dimensional image (D2), a blastomere area occupied by each blastomere and a fragmentation area...
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WO/2024/072614A1 |
The present disclosure provides a method of identifying a polypeptide. The method can include steps of (a) attaching a polypeptide to a particle or solid support, thereby producing an immobilized polypeptide having a plurality of amino a...
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WO/2024/071212A1 |
Provided are: a drug for forming and proliferating an organoid in the absence of an extracellular matrix, the drug containing an inhibitor for a Hippo signaling pathway as an active ingredient; a proliferation method of an organoid; an o...
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WO/2024/069581A1 |
Protein complexes including a cytidine deaminase and a helicase. In some embodiments, the cytidine deaminase is an altered cytidine deaminase. In some embodiments, the protein complex converts 5 methylcytosine to thymine. Kits, compositi...
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WO/2024/069939A1 |
The present invention pertains to a nucleic acid amplification cartridge (10) including a reaction tank (20). Water-soluble beads BP including a nucleic acid amplification primer and water-soluble beads BE including a nucleic acid amplif...
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WO/2024/070614A1 |
This test container is used for a nucleic acid amplification test executed in a nucleic acid amplification device. The test container comprises: a substrate; and a flowpath which is provided to the substrate and in which a sample contain...
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WO/2024/073708A1 |
Systems, methods, and compositions for identifying genomic variants and methylation analysis, including synthetic polynucleotide libraries, are provided. The synthetic polynucleotide libraries may comprise a plurality of polynucleotides....
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WO/2024/073712A1 |
This disclosure relates to novel thermophilic amplification compositions and methods, in particular for use in nucleic acid amplification and sequencing.
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WO/2024/072158A1 |
Provided are a biomarker for diagnosing pancreatic cancer, a composition containing an agent capable of detecting the biomarker for diagnosing pancreatic cancer, and a method for diagnosing pancreatic cancer using same.
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WO/2024/073034A1 |
The present invention provides methods and related compositions for producing a sequencing ready DNA library in as few as three steps by combining adapter ligation, degradation, fill-in, and amplification of adapter-DNA fragments into a ...
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WO/2024/071280A1 |
Provided, as an in-vitro evaluation system improved for evaluation of nephrotoxicity of a substance such as a compound, is a method for evaluating nephrotoxicity of a substance to be tested, the method involving a step for bringing the s...
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WO/2024/067478A1 |
The present invention provides a method for measuring a single-molecule RNA force spectrum and a use thereof. The method comprises the following steps: 1) obtaining a handle chain: designing and synthesizing a specially modified handle c...
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WO/2024/067848A1 |
Disclosed in the present invention are one or more blood extracellular vesicle miRNAs that can be used as biomarkers for diagnosis and early diagnosis of ovarian cancer, especially for distinguishing between benign and malignant ovarian ...
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WO/2024/068399A1 |
One aspect of the disclosure relates to a detection method for reliably detecting mutations of at least one target polynucleotide in a biological sample. The method comprises the step of providing in the same batch and from a common samp...
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WO/2024/068641A1 |
This disclosure relates to novel resynthesis kits and methods, in particular for use in pairwise sequencing.
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WO/2024/071429A1 |
The present invention relates to a method for preparing a double-stranded DNA library from single-stranded DNA fragments and provides a highly efficient library preparation method, etc., that generates or contains few adapter dimers. The...
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WO/2024/072161A1 |
The present invention relates to a biomarker for diagnosing pancreatic cancer low in CA19-9 level, a composition for diagnosing pancreatic cancer, including an agent capable of detecting the biomarker, and a method for diagnosing pancrea...
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WO/2024/066941A1 |
Provided is a composition for detecting bladder cancer. The composition comprises a detection reagent for detecting at least one of the following methylation sites: cg00206063, cg03278514, and cg13314394. Also provided are use of the com...
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WO/2024/073659A1 |
Methods, systems, and software components for identifying treatment regimens appropriate for pre-menopausal patients having hormone receptor-positive (HR(+)) breast cancer.
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WO/2024/069177A1 |
The present invention relates to methods for assaying viral nucleic acid impurities that might be present in adeno-associated virus (AAV) in a sample comprising recombinant AAV (rAAV) particles. More particularly, the present invention r...
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WO/2024/073508A2 |
Provided herein is a DNA analysis method for detecting and quantifying immune cell types from which the DNA originated. Provided herein are also methods for determining the likelihood that a subject has a disease or condition, such as ca...
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WO/2024/071361A1 |
The purpose of the present invention is to provide a screening method for a coagulation inhibition activity substance or a coagulation promotion activity substance for a coagulative protein. Specifically, the present invention pertains t...
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WO/2024/073652A1 |
The present inventions are directed to methods for detecting a neuroendocrine cancer in saliva, methods for determining the completeness of surgery, methods for determining whether a neuroendocrine cancer is stable or progressive, and me...
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WO/2024/070783A1 |
The purpose of the present invention is to provide a cell culture substrate equipped with a layered myocardial cell sheet for evaluating a therapeutic effect achieved by transplantation of a normal myocardial cell sheet and a method for ...
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WO/2024/071401A1 |
The present inventors found that enhancement of Plk1 activity induces lethal chromosome dynamic abnormalities in cancer cells and inhibits the proliferation thereof. Thus, activation of Plk1 and exacerbation of chromosome instability can...
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WO/2024/069007A2 |
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, diastereoisomer, enantiomer, polymorph, racemic mixture, solvate or isomers and mixtures thereof. The invention further relat...
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WO/2024/072951A1 |
The present disclosure relates to gene panels, materials, and methods for evaluation of cancer in a subject. In particular, provided herein are synthetic scaffolds and methods of use thereof for predicting or monitoring response to an im...
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