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WO/2024/080650A1 |
The present invention relates to a composition and method for predicting sulfonylurea dependency in diabetic patients by identifying the mRNA levels of gastric inhibitory polypeptide receptor (GIPR); the levels or activity of GIPR protei...
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WO/2024/079341A1 |
The present invention relates to a method for obtaining one or more fluorescent images of one or more cells, the method comprising the steps of incubating the one or more cells with a first probe for fluorescence imaging of nuclear DNA a...
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WO/2024/080483A1 |
The present invention relates to a CRISPR-Cas-based composition for detection of Listeria monocytogenes and a Listeria monocytogenes detection method using same and, more specifically, to a composition for detection of Listeria monocytog...
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WO/2024/077410A1 |
The present application relates to the technical field of metal ion chemistry, and provides a method for reducing an azide methoxy group, a sequencing method, and a kit. The method for reducing an azide methoxy group provided by the pres...
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WO/2024/081776A1 |
Disclosed are compositions and methods for performing nucleic-acid-based assays to determine the presence or absence of a target nucleic acid in a biological sample. The disclosed methods include the use of one or more oligomers that spe...
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WO/2024/081570A1 |
Aspects of the present disclosure relate to creating a graph, such as a directed-acyclic-graph (DAG), which represents the causal links in a biological process. In aspects, a researcher can establish the graph to incorporate the complexi...
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WO/2023/034602A9 |
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WO/2024/081040A1 |
Materials and methods for the diagnosis of traumatic brain injury using miRNA biomarkers are disclosed. Amplification nucleotide chains amplify a detectable signal indicating the expression and/or upregulation of the biomarkers. Detectio...
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WO/2024/080651A1 |
The present invention relates to a composition and a method, which can predict sulfonylurea dependence of diabetes patients by identifying: a first variant selected from the group consisting of a variant at base 43801878 (A allele), a va...
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WO/2024/077963A1 |
Disclosed in the present application is a primer-probe combination used for detecting influenza A viruses and influenza B viruses by means of recombinase polymerase amplification (RPA). The primer-probe combination comprises a probe and ...
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WO/2024/077984A1 |
The present invention belongs to the technical field of molecular breeding in maize. Provided are a maize dwarfing-related molecular marker having semi-dominance and the use thereof. The maize dwarfing-related molecular marker is caused ...
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WO/2024/077357A1 |
The present disclosure relates to methods for assessing the risk of a human subject for developing melanoma. Also provided are polymorphisms associated with the risk of a human subject for developing melanoma.
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WO/2024/081851A2 |
A method of synthesizing a polynucleotide composition includes performing a synthesis of the polynucleotide composition via phosphoramidite chemistry, solid-phase supported synthesis, to create polynucleotide chain. During at least one c...
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WO/2024/081313A1 |
A DNA collection system having: a DNA collection device including an elongated hollow housing having a first end and an opposed second end, and a plurality of DNA collection chambers mounted in a row in the housing, adjacent to the first...
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WO/2024/081873A1 |
The present invention provides a set of robust, genetic-based assays to screen for common abnormalities that occur in cultured cells utilizing a digital PCR (dPCR) platform.
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WO/2024/077856A1 |
Provided in the present invention is the use of a TBX family transcription factor as a target in the preparation of a drug for treating ophthalmic diseases. In the present invention, the TBX family transcription factor is used as a targe...
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WO/2024/077080A1 |
Provided herein are methods and systems for detection of cancer. The method may comprise using nucleic acids from a urine sample. The methods may comprise assaying nucleic acids in urine to detect a set of biomarkers from samples. The me...
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WO/2024/076675A2 |
Methods for analyzing the metastatic potential of circulating tumor cells (CTCs). Methods including analyzing growth signaling autonomy, methods for determining the likelihood of tumor metastases, and methods of treating a cancer determi...
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WO/2024/077097A1 |
Blood and lung infections are a worldwide health problem with approximately five million deaths each year. Early treatment could help save lives, but better tests to identify these infections are needed. This invention identifies pathoge...
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WO/2024/077224A2 |
The present invention relates to compositions and methods for preventing or treating diseases or disorders involving nucleic acid damage, such as cancer, in a subject, as well as methods of identifying gut microbes, strains or metabolite...
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WO/2024/076805A2 |
A method for producing a positive antigen-based control for detecting a pathogen which includes providing a culture fluid having a pathogen with a first detectable antigen, wherein the culture fluid has a first concentration of the first...
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WO/2024/076689A2 |
Aspects of the present disclosure provide complexes configured to selectively bind nucleic acids of particular sizes, sequences, and chemical modifications. The disclosure further outlines methods for using these nucleic acid binding com...
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WO/2024/075559A1 |
This nucleic acid extraction method comprises: producing an antibody-copolymer conjugate by preparing, in the absence of a protease, a mixture including at least one sample selected from the group consisting of cells, extracellular vesic...
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WO/2024/074669A1 |
The invention provides a method for detection of at least one molecular genetic analyte comprising a upstream and a competitive downstream oligonucleotide probe, wherein the upstream probe has a sequence region (1) and the downstream pro...
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WO/2024/076925A1 |
Applicant provides herein methods for treating a patient having a pre-cancerous oral leukoplakia (LK) lesion or for delaying the progression of a pre-cancerous oral LK to oral squamous cell carcinoma. It also provides methods to identify...
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WO/2024/076469A1 |
The present disclosure provides methods for preparation and analysis of biological samples of maternal transplant recipients, wherein the methods comprise extracting cell-free DNA from the recipient, wherein the cell-free DNA comprises d...
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WO/2024/076307A1 |
Disclosed herein are compositions and methods for application of the same for use in the pre- analytical workflow for the assessment of nucleic acids in biological samples as well as biomarkers and reagents applicable for quality control...
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WO/2024/074133A1 |
Provided is a protein marker Nell-1, which is present in a person's blood sample in an amount that is correlated with neurodegenerative disorders such as Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), and Parkinson's Disease ...
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WO/2024/076573A2 |
Provided herein are systems and methods that combine the use of first and second optical transformations (e.g., implemented using optical photon reassignment (OPRA)) with time delay and integration (TDI) imaging and external illumination...
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WO/2024/077282A2 |
Embodiments of the invention include a system and method of using biomarkers in detecting or diagnosing amyotrophic lateral sclerosis (ALS). A subject can be screened for ALS based on altered expression of one or more biomarkers in blood...
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WO/2024/076769A1 |
Methods for pre-screening subjects for cancer are disclosed. Genetic risks associated with genetic signatures are determined by sequencing and analyzing cell free DNA ("cfDNA") fragments present in the subject's blood sample. Clinical ri...
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WO/2024/074558A1 |
The present invention relates to the field of pharmacogenomics and in particular to detecting the presence or absence of circulating tumor DNA in blood or blood-derived samples or in other body fluids that contain DNA released from a tum...
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WO/2024/076994A1 |
Disclosed are an assay, method, and kit for detecting a monkeypox virus (MPXV) and the application thereof. The assay may be used alone or in combination with another assay or assays. The method of using and kit includes a composition us...
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WO/2024/076967A1 |
The present invention provides compositions and methods for reducing the level and/or activity of a TET protein, for treating or preventing a disease and disorder associated with an increased level and/or activity of a TET protein, for r...
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WO/2024/076981A2 |
Methods of amplifying libraries after introduction of dihydrouracil (DHU) residues by methods such as TET-assisted Pyridine Borane Sequencing (TAPS), and variants of TAPS including TAPS with blocking by β-glucosylation (TAPSβ) and Chem...
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WO/2024/075828A1 |
A data collection method for determining the likelihood of a subject developing Alzheimer's disease, the method comprising measuring, in a biological specimen of the subject, the proportion of methylated DNA in a CpG island including a c...
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WO/2024/074412A1 |
Methods of sequencing by expansion and related improvements to the sequencing of surrogate polymers in a nanopore are described. The surrogate polymer is formed from a template nucleic acid molecule. A surrogate polymer includes multiple...
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WO/2024/075020A1 |
Provided herein are methods, assays and kits for detecting methylated genomic DNA and one or more protein biomarkers in one or more biological samples. In some aspects, the disclosure provides methods, assays and kits for detecting or pr...
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WO/2024/076118A1 |
The present invention pertains to: an iron single atom-based peroxidase-mimicking hydrogel nanozyme; a method for producing same; and a foldable paper biosensor including same. More specifically, an iron single atom-based peroxidase-mimi...
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WO/2024/076910A2 |
Organoid culture and image-processing methods and systems are described. Such methods and systems provide the ability for high-throughput characterization of a variety of phenotypes at single-organoid resolution.
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WO/2024/077166A1 |
The invention provides methods for classifying lung cancer (e.g., small cell lung cancer (SCLC), e.g., extensive stage SCLC (ES-SCLC)); methods for treating lung cancer in a patient, for example, by administering a treatment regimen that...
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WO/2024/077152A1 |
Described herein are methods for depleting library fragments prepared from off-target RNA sequences. Libraries enriched or depleted with the present methods may be used for sequencing. Also described are probes and methods for depletion ...
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WO/2024/077197A1 |
A method, composition and kit for determining the presence or absence of Salmonella sp., Shigella sp./Enteroinvasive Escherichia coli (EIEC), and Campylobacter sp. in a sample, comprising producing an amplicon by subjecting a reaction mi...
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WO/2024/075845A1 |
The present disclosure provides an appropriate cell culture. In one aspect, the present disclosure provides a cell culture system. In one embodiment, the system of the present disclosure has a function of providing information for approp...
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WO/2024/074726A1 |
The present invention provides a method for monitoring an in vitro transcription (IVT) reaction for the production of RNA within a reaction vessel. The method comprises obtaining a spectrum of a reactant or product during the IVT reactio...
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WO/2024/076978A1 |
An engineered host cell comprising a genetic construct comprising a reporter gene under the control of a uric acid-responsive promoter, and a method for using such a cell to detect uric acid concentrations in a subject. An engineered hos...
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WO/2023/056350A9 |
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
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WO/2024/077095A1 |
The invention provides methods for classifying bladder cancer (e.g., urothelial cancer (UC), e.g., locally advanced or metastatic UC); methods for treating bladder cancer in a patient, for example, by administering a treatment regimen th...
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WO/2024/077047A1 |
The present disclosure relates in some aspects to methods and compositions for generating modified surfaces for microfluidic device (e.g., flow cells) and for characterizing the surface chemistry of the modified surfaces, such as the rel...
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WO/2024/077162A2 |
Described herein are compositions and methods for enriching library fragments prepared for coronavirus sequences prepared from various samples. These methods may incorporate microfluidics and flowcells for greater ease of use. Libraries ...
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