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WO/2024/096536A1 |
The present invention relates to a DNA methylation marker for diagnosing lung cancer and uses thereof, and more specifically to: a DNA methylation marker combination capable of determining the presence or absence of lung cancer; and uses...
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WO/2024/093961A1 |
Provided are a method for reduced-representation genome sequencing and related use. The method comprises: digesting a re-sequencing library with a restriction endonuclease, and sorting fragments with a target length and no enzyme digesti...
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WO/2024/097393A1 |
Provided herein are systems, compositions, and methods for single cell analysis. In particular, provided herein are systems, compositions, and methods for scalable, high-throughput isolation and sequencing of nucleic acids from rare and/...
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WO/2024/095258A1 |
The present invention is in the field of tomato plant growth and development, particularly relating to positive non-additive (epistatic) interactions between quantitative trait loci (QTLs) conferring enhanced productivity and drought tol...
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WO/2024/096121A1 |
The present disclosure provides a bacterial preparation that can be used to treat inflammatory bowel disease. More specifically, the present disclosure relates to a microorganism in which a gene from at least one of a fimbria operon gene...
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WO/2024/092946A1 |
Provided are a universal kit and method for extracting microorganism DNA and use. The kit comprises a pretreatment solution, an enzymolysis buffer, a lysis buffer, a magnetic bead purifying solution, an eluent, and a protective solution....
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WO/2024/097718A1 |
Disclosed herein include systems, methods, compositions, and kits for generating protected cellular component-binding compositions. There are provided, in some embodiments, protected cellular component-binding compositions comprising a c...
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WO/2024/098029A2 |
The present disclosure relates to methods of directly measuring absolute length of individual telomeres without any PCR amplification or fluorescent probe hybridization. This method can be performed in a high-throughput 96-well plate for...
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WO/2024/097756A1 |
Aspects of the disclosure relate to compositions and methods for the diagnosis and/or treatment of certain neurodegenerative diseases, for example those diseases associated with repeat-associated non-ATG (RAN) translation proteins, such ...
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WO/2024/097878A1 |
Provided herein are methods of predicting a risk of developing an immune-related adverse event (irAE) from an immune checkpoint inhibitor (ICI) therapy. The methods include the classification of T cell receptor p genes as productive TCRÎ...
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WO/2024/095015A1 |
The invention relates to an assay. More specifically, the invention relates to an assay for predicting cardiovascular toxicity of a chemotherapeutic agent.
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WO/2024/097727A2 |
An automated analyzer can include a plate sealer and a drawer assembly. The plate sealer can include a heated press plate configured to apply heat and pressure to a seal material, wherein the seal material is configured to seal against a...
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WO/2024/095989A1 |
The present invention addresses the problem of providing: a method for selectively measuring the number of cells of a bacterium capable of activating a plasmacytoid dendritic cell (e.g., a lactic acid bacterium such as a bacterium of str...
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WO/2024/097740A1 |
The present disclosure relates to the simultaneous imaging of nucleic acids and proteins in a sample. In particular, the present disclosure provides compositions, methods, systems and kits for imaging at least one target protein and at l...
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WO/2024/097217A1 |
The methods, systems, and compositions provided herein allow improved methods for detecting non-cancer somatic mutations in a subject by measuring buffy coat somatic mutations in order to improve identification of samples with age relate...
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WO/2024/092963A1 |
Disclosed are an intestinal flora-based Alzheimer's disease biomarker and use thereof. The Alzheimer's disease biomarker is an intestinal microorganism, and the intestinal microorganism includes any one of or a combination of at least tw...
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WO/2024/098003A1 |
Provided herein are biomarkers present in cell-free DNA (cfDNA) for the early detection of pre-clinical Alzheimer's Disease (AD), mild cognitive impairment (MCI), or AD in a subject. The detection of such biomarkers in a subject may be u...
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WO/2024/097719A1 |
Disclosed herein include systems, methods, compositions, and kits for prevention of antibody oligonucleotide extension. There are provided, in some embodiments, blocking oligonucleotides. In some embodiments, the blocking oligonucleotide...
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WO/2024/096129A1 |
Disclosed is a biomarker for use in the prediction of the occurrence and the severity of acne vulgaris, and in the determination of the severity of acne vulgaris.
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WO/2024/097998A1 |
The present disclosure relates to an improved biomarker, termed a composite biomarker score, which integrates several individual biomarkers into a more precise and more accurate predictor of response to immune checkpoint inhibitor therap...
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WO/2024/097309A1 |
Disclosed herein are methods and systems comprising obtaining nucleic acid from a sample that was obtained from a subject; capturing and amplifying a target molecule in the nucleic acid using a molecular inversion probe under hybridizati...
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WO/2024/096661A1 |
The present invention relates to a method for selectively differentiating and isolating, from pluripotent stem cells, neural crest stem cells comprising axial specification information in the human body. According to the method of the pr...
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WO/2024/093179A1 |
Provided are a pan-tumor blood diagnosis marker and a use thereof. Provided is a sample classification method. The classification method comprises the following steps: acquiring sequencing data of free DNA of a sample; comparing the sequ...
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WO/2024/092904A1 |
Provided are a nucleic acid detection kit and a detection method based on a CRISPR/Cas12a system. The kit comprises a crDNA amplification primer pair, a Cas12a protein, a DNA polymerase for variable temperature amplification, an RNA poly...
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WO/2024/044789A9 |
Proper functioning of the human body relies on the organization of cells in 3D space. A cell's function and fate are determined by its biomolecule composition and 3D environment. The spatial identification of proteins, RNAs, DNAs, and ot...
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WO/2024/094233A1 |
The invention provides a method for determining specificity of inhibitors of tested protein - nucleic acid interactions, comprising the following steps: a) providing a multiwell plate having DNA probes bound to a plurality of wells in th...
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WO/2024/096737A1 |
The present invention provides an in vitro method for determining the physiological age of blood platelets in a test sample wherein said physiological age is expressed in days and/or hours. The method comprises providing a test sample of...
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WO/2024/094095A1 |
A method of generating an antibody specific for a target antigen, the method comprising (a) subject an animal to one or more rounds of immunization with the target antigen; (b) collecting a first sample of B cells from the animal; (c) id...
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WO/2024/090562A1 |
Provided is a method for producing a glutamate dehydrogenase of which the coenzyme is FAD. Also provided is a FAD-dependent glutamate dehydrogenase having a specified amino acid substitution.
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WO/2024/088538A1 |
The invention relates to methods for diagnosing, predicting disease development, disease progression and/or disease outcome, predicting susceptibility to treatment and/or classification in the context of diseases or disorders of the fema...
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WO/2024/092138A1 |
Methods for disease risk assessment using multiple data sources, and computer programs for implementing same.
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WO/2024/091123A1 |
The invention relates to means and methods for analysis of target analytes using nanopore-based sensors, more in particular to methods, nanopore systems and devices for single-molecule profiling of polymers, e.g. polypeptide or polysacch...
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WO/2024/088864A1 |
The invention is directed to a method for determining the spatial localisation and a sequence of interest of at least a part of at least one RNA strand comprising the steps a. providing a plurality of oligonucleotides comprising a unit c...
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WO/2024/091186A1 |
The current invention relates to a method of quantitatively determining the concentration of active myrosinase in a sample, the method comprising the steps of (a) adding a portion of the sample comprising active myrosinase to a first ana...
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WO/2024/089063A1 |
The present invention refers to an in vitro method for predicting the prognosis of renal carcinoma, for predicting the benefit of patients suffering from renal carcinoma from a treatment with antibody-based immunotherapy and/or for decid...
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WO/2024/092189A2 |
The present disclosure provides compositions and methods related to nucleic acid sensors. In particular, the present disclosure provides nucleic acids molecules that target transcripts of a gene or chromosomal fusion and activate a downs...
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WO/2024/091936A1 |
A fluidic device, instrument, and method for processing a biological sample is disclosed herein. An example of the fluidic device includes structures (e.g., sample holder(s), reaction chamber(s), reagent storage zone(s), metering compart...
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WO/2024/091807A1 |
The present disclosure provides systems and methods for detecting the presence of colonies on agar plates. The systems and methods are suitably useful for evaluating the presence of a contaminant (e.g., bacterial, fungal, etc.) in a samp...
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WO/2024/091883A2 |
Provided herein are methods of sex-sorting a plurality of insects based on sex-specific gene expression, the method comprising (a) generating an exogenous nucleic acid molecule; (b) delivering the exogenous nucleic acid molecule into an ...
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WO/2024/089270A2 |
The present invention relates to novel pore monomers, pores formed from the pore monomers and their uses in analyte detection and characterisation.
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WO/2024/091028A1 |
The present invention relates to a system and method for more effectively determining a health status and diagnosing and predicting diseases by utilizing epigenome and mutation information of cfDNA fragments in body fluids and cfDNA frag...
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WO/2024/090805A1 |
The present invention relates to methylation markers and combinations thereof for diagnosing lung cancer. More specifically, the present invention relates to methylation markers that specifically show decreased or increased methylation i...
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WO/2024/092151A1 |
Provided herein is a method for analyzing cells. In some embodiments the method may comprise base editing a target gene in a population of cells to produce genetically modified cells, reverse transcribing mRNA from single cells in the po...
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WO/2024/090514A1 |
A three-dimensional skin model according to one embodiment of the present invention comprises: a first layer including keratinocytes or cells with differentiated keratinocytes; a second layer including dermal fibroblasts; and an intermed...
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WO/2024/092169A2 |
Various embodiments are directed to analyzing host gene expression levels and microbial diversity in a biological sample, to determine a likelihood of lower-respiratory tract infection (LRTI) in subjects. Embodiments can include determin...
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WO/2024/091020A1 |
The present invention relates to an extracellular vesicle-derived miRNA gene biomarker for breast cancer diagnosis or recurrence prediction and to a use thereof and, more specifically, provides an miRNA gene biomarker associated with bre...
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WO/2024/091905A2 |
Cas protein variants with improved specificity against mismatches between the guide RNA and an RNA target of interest are described. Also described are novel in-silico strategies for designing high specificity Cas variants, a method of d...
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WO/2024/086949A1 |
A method of isolating and purifying double stranded RNA (dsRNA) from a sample includes treating a crude RNA extract containing dsRNA obtained from a sample with a B2 dsRNA-binding protein to form a B2-dsRNA mixture containing a B2-dsRNA ...
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WO/2024/091998A1 |
Systems, methods, and devices disclosed herein provide antibiotic resistance predictions using a pan-antibiotic resistance prediction (PARP) model. The PARP model includes a machine learning system trained with a training data set of gen...
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WO/2024/087336A1 |
Disclosed in the present invention are an all-genetically encoded NMN protein probe based on resonance energy transfer, and a use thereof, and particularly, an all-genetically encoded NMN protein probe, which is formed by connecting a re...
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