Title:
TUMOR MICROFLUIDIC CHIP FOR SCREENING MESENCHYMAL STEM CELL MIGRATION AND PREPARATION AND USE METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/082430
Kind Code:
A1
Abstract:
A tumor microfluidic chip for screening mesenchymal stem cell migration, and a preparation and use method therefor. The microfluidic chip comprises a chip main body having a microstructure channel machined on the surface, and a substrate tightly attached to the chip main body. The microstructure channel on the chip main body comprises a central cell culture channel, and a plurality of independent cell migration units which are symmetrically arranged on the two sides of the central cell culture channel. Each cell migration unit comprises a matrix gel perfusion channel on the inner side, and a migration cell culture channel on the outer side. Intercepting structures are arranged between the central cell culture channel and the matrix gel perfusion channel of each cell migration unit and between the matrix gel perfusion channel and the migration cell culture channel of the same cell migration unit.
More Like This:
Inventors:
ZHU XUEQIONG (CN)
SONG YIZUO (CN)
SHANG LUORAN (CN)
SHOU XIN (CN)
SONG YIZUO (CN)
SHANG LUORAN (CN)
SHOU XIN (CN)
Application Number:
PCT/CN2022/140871
Publication Date:
April 25, 2024
Filing Date:
December 22, 2022
Export Citation:
Assignee:
THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDRENS HOSPITAL OF WENZHOU MEDICAL UNIV (CN)
International Classes:
C12M3/00; C12Q1/02
Foreign References:
| CN106566863A | 2017-04-19 | |||
| CN114480122A | 2022-05-13 | |||
| CN103627635A | 2014-03-12 | |||
| US20110159522A1 | 2011-06-30 | |||
| CN105713835A | 2016-06-29 | |||
| CN107955783A | 2018-04-24 | |||
| CN106544271A | 2017-03-29 | |||
| CN107955784A | 2018-04-24 |
Attorney, Agent or Firm:
NANJING ZHONGSHAN PATENT AGENT CO. (CN)
Download PDF: