METHOD, KIT AND SYSTEM FOR END LABELING OF NUCLEIC ACIDS

Title:

METHOD, KIT AND SYSTEM FOR END LABELING OF NUCLEIC ACIDS

Document Type and Number:

WIPO Patent Application WO/2024/059788

Kind Code:

A3

Abstract:

Provided is a method for labeling a nucleic acid, including providing a target nucleic acid to be labeled; providing a 5'-end glycosylase to react with the target nucleic acid to create an intermediate nucleic acid having an abasic site at a 5'-end; and providing an aldehyde-reactive compound carrying a detectable label for coupling with the intermediate nucleic acid to form a labeled nucleic acid with the detectable label attached at the 5'-end. Also provided is a kit and a system for labeling nucleic acids.

Inventors:

CHEN CHENG-YAO (TW)
CHENG YI-WEN (TW)

Application Number:

PCT/US2023/074293

Publication Date:

April 25, 2024

Filing Date:

September 15, 2023

Export Citation:

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Assignee:

CHEN CHENG YAO (TW)

International Classes:

C12Q1/68; C12P19/34; C12Q1/6806; G01N21/64

Attorney, Agent or Firm:

HSU, Winston et al. (TW)

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