Title:
TRUNCATED RESPIRATORY SYNCYTIAL VIRUS F PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/082681
Kind Code:
A1
Abstract:
Provided are a fusion protein, and a nucleic acid molecule comprising a nucleotide sequence encoding the fusion protein. The present invention also relates to a vaccine comprising the fusion protein or the nucleic acid molecule. Furthermore, the present invention also relates to a method for preventing and/or treating RSV infections or diseases and/or symptoms caused by RSV infections by means of using the fusion protein, the nucleic acid molecule and the vaccine.
Inventors:
ZHENG ZIZHENG (CN)
LIN MIN (CN)
YIN YIFAN (CN)
WANG CHEN (CN)
ZHAO XIAOMENG (CN)
CHEN LI (CN)
ZHANG JUN (CN)
XIA NINGSHAO (CN)
LIN MIN (CN)
YIN YIFAN (CN)
WANG CHEN (CN)
ZHAO XIAOMENG (CN)
CHEN LI (CN)
ZHANG JUN (CN)
XIA NINGSHAO (CN)
Application Number:
PCT/CN2023/102342
Publication Date:
April 25, 2024
Filing Date:
June 26, 2023
Export Citation:
Assignee:
UNIV XIAMEN (CN)
XIAMEN INNOVAX BIOTECH CO LTD (CN)
XIAMEN INNOVAX BIOTECH CO LTD (CN)
International Classes:
C07K19/00; A61K39/155; C07K16/10; C12N15/62; C12N15/86; C12Q1/02; G01N33/569; G01N33/68
Foreign References:
| CN105473604A | 2016-04-06 | |||
| CN113811549A | 2021-12-17 | |||
| US20190330277A1 | 2019-10-31 | |||
| CN109069611A | 2018-12-21 | |||
| CN111405907A | 2020-07-10 | |||
| US20140271699A1 | 2014-09-18 | |||
| CN111655715A | 2020-09-11 |
Other References:
JEFFREY C. BOYINGTON, JOYCE, SASTRY MALLIKA, STEWART-JONES GUILLAUME B. E., CHEN MAN, KONG WING-PUI, NGWUTA JOAN, THOMAS PAUL, TSY: "Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 11, no. 7, 27 June 2016 (2016-06-27), pages e0159709, XP055383885, DOI: 10.1371/journal.pone.0159709
KRARUP, A. ET AL.: "A Highly Stable Prefusion RSV F Vaccine Derived from Structural Analysis of the Fusion Mechanism", NATURE COMMUNICATIONS, vol. 6, 3 September 2015 (2015-09-03), XP002755858, DOI: 10.1038/ncomms9143
RUIZ-ARGUELLO, B.M. ET AL.: "Thermostability of the Human Respiratory Syncytial Virus Fusion Protein before and after Activation: Implications for the Membrane-Fusion Mechanism", JOURNAL OF GENERAL VIROLOGY, vol. 85, 31 December 2004 (2004-12-31), XP007917291, DOI: 10.1099/vir.0.80318-0
KRARUP, A. ET AL.: "A Highly Stable Prefusion RSV F Vaccine Derived from Structural Analysis of the Fusion Mechanism", NATURE COMMUNICATIONS, vol. 6, 3 September 2015 (2015-09-03), XP002755858, DOI: 10.1038/ncomms9143
RUIZ-ARGUELLO, B.M. ET AL.: "Thermostability of the Human Respiratory Syncytial Virus Fusion Protein before and after Activation: Implications for the Membrane-Fusion Mechanism", JOURNAL OF GENERAL VIROLOGY, vol. 85, 31 December 2004 (2004-12-31), XP007917291, DOI: 10.1099/vir.0.80318-0
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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