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WO/2024/083910A1 |
The present invention relates to a new bacterial strain and a new urolithin named urolithin G. The new strain of the invention is Enterocloster bolteae CEBAS S4A9 DSM 34392 and can customize urolithin production to mimic metabotype A and...
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WO/2024/082757A1 |
Provided are the use of chlorflavonin and derivatives thereof, in particular the use thereof in inhibiting the growth of microorganisms and inhibiting the growth of plants. Also provided are genes associated with the synthesis of flavone...
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WO/2024/078646A1 |
A method for preparing (R)-tebuconazole by means of an enzyme chemical process, comprising: firstly, by taking the whole cell of recombinant bacterium E. coli/Rpeh expressing an epoxide hydrolase as a catalyst, resolving a racemic tebuco...
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WO/2024/078368A1 |
A method for preparing a halogenated indole glucoside and Tyrian purple. The method comprises: a halogenation step, involving halogenating tryptophan to obtain halogenated tryptophan; and a glucoside preparation step, involving mixing th...
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WO/2023/056350A9 |
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
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WO/2024/073755A2 |
Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids ("BIAs") such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocod...
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WO/2024/068434A2 |
The present invention relates to methods for making compounds of formula (I) including violacein, violacein analogues and derivatives thereof, and to compositions, cells, and fermentation liquids comprising the compounds resulting from t...
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WO/2024/066402A1 |
Provided are an enzyme immobilization carrier and a preparation method therefor, an immobilized enzyme and a preparation method therefor, and use thereof. The enzyme immobilization carrier comprises a resin matrix and a divinyl sulfone g...
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WO/2024/065882A1 |
An amino acid-based multifunctional water-based liquid, a preparation method therefor and a use thereof. In the water-based liquid, water is used as a solvent, and viscous droplets rich in amino acids, oligopeptides or/and amino acid/oli...
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WO/2024/064811A2 |
Provided are non-naturally occurring polynucleotide sequences that encode for polypeptides useful in ergoline biosynthesis, as well as the non-naturally occurring polypeptide sequences. Also provided are recombinant host cell and methods...
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WO/2024/059517A1 |
Described herein are CB5 polypeptides for the biosynthesis of oxygenated hydrocarbons in modified host cells.
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WO/2024/054111A1 |
The invention provides a method for providing a lactone (10), wherein the method comprises: (i) a preparation stage comprising providing a first compound (1) according to formula (I) wherein X is selected from the group comprising O, NH,...
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WO/2024/050928A1 |
Disclosed in the present invention is a method for preparing pyrrolidone. Provided in the present invention is a method for preparing pyrrolidone from γ-aminobutyric acid under the catalysis of carnitine-CoA ligase CaiC. The amino acid ...
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WO/2024/052511A1 |
The invention relates to a method for preparing a compound of formula (III) or an edible salt thereof, specifically to an enzyme-catalysed method. Such compounds are preferably flavor modulation compounds.
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WO/2024/050589A1 |
The present invention provides compositions comprising microbial biomass, one or more lactones and/or one or more 4-hydroxy fatty acids, as well as food products, beverage products or feedstuffs comprising microbial biomass, one or more ...
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WO/2024/044987A1 |
The present invention provides a monooxygenase mutant and use thereof. The monooxygenase mutant comprises (a) a protein having an amino acid sequence set forth in SEQ ID NO: 1; or (b) a protein that undergoes an amino acid mutation at at...
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WO/2024/041629A1 |
The present invention provides a preparation method for R-type ketorolac and use thereof, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: step 1, preparing ketorolac; and ste...
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WO/2024/039529A1 |
Improved yields of melanin are obtained by incubating, in an optimized media with a disodium tyrosine substrate, a culture of Vibrio natriegens expressing a heterologous tyrosinase gene at a temperature of about 30°C.
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WO/2024/040211A2 |
The invention is directed to methods involved in the production of flavonoids, anthocyanins and other organic compounds. The invention provides cells engineered for the production of flavonoids, anthocyanins and other organic compounds, ...
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WO/2024/030866A1 |
Systems and methods for prenylation and recombinant pathways for the production of compounds, cannabinoids, cannabinoid precursors, and other prenylated chemicals in a cell free system. The present invention further includes enzymes and ...
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WO/2024/030662A1 |
The disclosure provides host cells engineered to express non-naturally occurring polyketide synthases that produce b-keto-d-lactones (BKDLs); methods of generating such host cells, and methods of producing BKDLs employing the host cells.
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WO/2024/027251A1 |
Disclosed is a method for producing 7-hydroxybutylphthalide by means of fermentation of Penicillium vulpinum. In this method, an NCC3421 strain is used, formulas, process parameters, and the like of a shake flask seed culture solution, a...
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WO/2024/023260A1 |
The present invention relates to a method for producing at least one target compound selected from a terpenoid, a phenolic compound, a vitamin, and a combination thereof in a yeast cell from the family Trichosporonaceae. The present inve...
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WO/2024/023259A1 |
The present invention relates to a compound of formula I, a stereoisomer, a tautomer and/or a dimer thereof or a salt thereof, (I) wherein M is a metal among the group of Mg, Cu and Zn; R1 is a methyl group or a formyl group; R2 is a car...
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WO/2024/022574A1 |
The present invention relates to methods for converting unsaturated macrocyclic ketones to lactones wherein the conversion is catalyzed by a Baeyer-Villiger monooxygenase (BVMO). The invention also relates to the use of a Baeyer-Villiger...
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WO/2024/013212A1 |
The present disclosure relates to a genetically modified host cell having improved production of thiamine, wherein the host cell expresses one or more heterologous ThiO enzymes converting glycine into dehydroglycine (DHG) in the host cel...
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WO/2024/013383A1 |
The present invention relates to a mutant ketoreductase, a nucleic acid encoding the mutant ketoreductase, a vector comprising the nucleic acid, a method for the enzymatic reduction of a prochiral ketone and the formation of a chiral alc...
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WO/2023/245815A1 |
The present invention provides a transaminase mutant and a preparation method for a chiral amine compound. The transaminase mutant comprises: (a) a protein comprising an amino acid sequence represented by SEQ ID NO: 1; or (b) a protein c...
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WO/2023/242195A1 |
The present invention relates to cannabichromenic acid synthase (CBCAS) variants that have increased enzymatic activity and thus allow efficient recombinant production of cannabichromenic acid (CBCA). The invention further relates to nuc...
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WO/2023/245039A1 |
Variants of squalene hopene cyclase (SHC) are provided for enzymatically converting homofarnesoic acid to sclareolide, which can be non-enzymatically converted to ambrox.
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WO/2023/245049A2 |
Provided are compositions and methods for producing dihydrofurans by way of glycosyl hydrolases that can dehydrate 2-keto-3-deoxy-gluconate (KDG) to K4. Provided are also compositions and methods for further processing K4 to create HMFA ...
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WO/2023/244802A2 |
The present disclosure provides a bacterial and yeast co-culture system and methods of making and using such co-culture systems for producing strigolactones.
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WO/2023/240679A1 |
The present invention relates to the technical field of medicines, and disclosed are a pair of polyketide compounds having anti-inflammatory activity, a preparation method therefor, and a use thereof. Specifically, endophytic fungus Alte...
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WO/2023/234307A1 |
The purpose of the present invention is to enhance ergothioneine productivity in ergothioneine production through culturing of an ergothioneine-producing filamentous fungus. In the present invention, a genetic mutation that enhances er...
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WO/2023/234277A1 |
Provided is a production method for obtaining pyridoxamine phosphate having high coenzyme activity with AST or ALT. For the production of pyridoxamine phosphate, pyridoxal kinase and pyridoxamine are brought into contact in the presenc...
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WO/2023/232125A1 |
The present invention relates to a sesquiterpene polyketone compound that can be used as immunomodulator, or a pharmaceutical composition. An activity experiment shows that the sesquiterpene polyketone compound provided by the present in...
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WO/2023/222515A1 |
The present invention relates to a recombinant microbial cell for producing at least one compound having structural Formula III from at least one simple carbon source: Formula (III) m = 1-3, wherein the simple carbon source is selected f...
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WO/2023/222075A1 |
The present invention provides a method for increasing a fermentation yield of PF1022A. By using a Rosellinia sp. strain that can produce PF1022A as a production strain, aerobic fermentation is carried out in a fermentation medium. The f...
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WO/2023/218197A1 |
The present invention relates to biopesticides and their use in crop protection. In particular the present invention relates to modified Paraburkholderia cells comprising a heterologous biosynthetic gene cluster for producing an antimicr...
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WO/2023/213276A1 |
Provided is a chemical-enzyme coupling method for synthesizing ergothioneine. The method comprises the steps of chemically synthesizing histidine betaine, and synthesizing ergothioneine from the histidine betaine by using Schizosaccharom...
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WO/2023/213016A1 |
Provided are a genetically engineered bacterium for producing catharanthine by fermentation, and use thereof. The catharanthine is produced by fermenting microorganisms with a simple carbon source as a substrate, thereby realizing the de...
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WO/2023/208146A1 |
Provided are a method and carrier for the biosynthesis of ergothioneine. The method comprises: introducing into a host cell at least one nucleic acid construct of a polynucleotide sequence comprising: a coding glutamylcysteine synthetase...
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WO/2023/207565A1 |
A method for preparing a lactobionic acid fermentation composition on the basis of a supermolecular solvent of betaine and skincare use thereof. The method comprises: (1) preparing a supermolecular NaDES solvent of mandelic acid and beta...
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WO/2023/199929A1 |
For equol manufacture using microorganisms, the present invention provides a method by which equol can be effectively manufactured at safer and lower hydrogen concentrations than in the past. The present invention provides an equol manuf...
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WO/2023/197952A1 |
Provided are a yeast extract with high base and base derivative contents and a method for preparing same. The yeast extract with high base and base derivative contents provided herein comprises 20000-40000 mg/kg of bases and base derivat...
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WO/2023/191452A1 |
An improved method of producing gamma-butyrolactone (GBL) product with high purity in high yield from a starting biomass containing poly-4-hydroxybutyrate (P4HB) and water is disclosed. The method includes recycling a part of GBL product...
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WO/2023/185184A1 |
Provided are monoamine oxidase and an application thereof in a biocatalytic method.
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WO/2023/184724A1 |
Disclosed in the present invention are an antimycin compound as well as a preparation method therefor and the use thereof. The compound is characterized in that the compound is separated from a secondary metabolite of marine actinomycete...
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WO/2023/182610A1 |
The present invention relates to a method for mass production of fulvic acid from humus soil. A method for extracting fulvic acid from humus soil according to the present invention employs at least one enzyme selected from the group cons...
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WO/2023/183543A1 |
Disclosed is a method for forming selenoneine or analogs thereof. The method may include phosphorylating sodium selenide to a selenophosphate, using adenosine triphosphate (ATP) and at least a first protein, generating a selenosugar by c...
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