| Document |
Document Title |
|
WO/2022/186328A1 |
The present invention relates to a compound represented by formula (I), and an antimalarial drug comprising the compound.
|
|
WO/2022/170438A1 |
Disclosed are novel multi-substituent psilocybin derivative compounds and pharmaceutical and recreational drug formulations containing the same. The compounds may be produced by reacting a reactant psilocybin derivative with a substituen...
|
|
WO/2022/173436A1 |
The present disclosure describes the engineering of microbial cells for fermentative production of ectoine and provides novel engineered microbial cells and cultures, as well as related ectoine production methods.
|
|
WO/2022/166104A1 |
Provided is a method for synthesizing a chiral amine compound. An amino reaction is performed on a ketone substrate by means of a transaminase under the action of an amino donor, and the chiral amine compound is obtained. A conserved ami...
|
|
WO/2022/166459A1 |
A fermentation method for mupirocin, the method comprising performing shake flask seed culture, seed tank culture, fermentation culture, and feed culture. The fermentation method is not only suitable for industrial mass production, but a...
|
|
WO/2022/166103A1 |
Provided are a transaminase mutant and an application thereof. The transaminase mutant is obtained by mutating one or more amino acids in SEQ ID NO: 2 or is a mutant obtained by taking the sequence SEQ ID NO: 1 of wild-type CVTA transami...
|
|
WO/2022/164870A1 |
Provided is a nucleic acid comprising a recombinant bacterial or archaeal geranyl pyrophosphate synthase (GPPS) gene, codon optimized for production in yeast. Also provided is a yeast cell comprising an expression cassette comprising the...
|
|
WO/2022/165169A1 |
The present disclosure concerns methods of using Pseudomonas chlororaphis subsp. aurantiaca 1214-CHY4 (Accession No. PTA-126941), the cell broth and novel metabolites produced therefrom, that can inhibit the growth of a variety of microb...
|
|
WO/2022/162101A1 |
The present invention relates to a process for providing an isolated taxane compound from a plant material comprising a taxane compound, the process comprises the steps of (i) providing the plant material comprising a taxane compound; (i...
|
|
WO/2022/157180A1 |
The invention relates to process for isoprenoid production by an in-vitro synthetic platform involving at least the steps of phosphorylating a first hemiterpene alcohol with a first phosphate donor under catalysis of a first kinase there...
|
|
WO/2022/156857A1 |
The invention relates to a process for preparing 2,4-dihydroxybutyrate (DHB) or L-threonine using a microbial metabolic pathway, the metabolic pathway being expressed in a microbial production strain that has been previously modified as ...
|
|
WO/2022/155751A1 |
Disclosed are novel prenylated psilocybin derivative compounds and pharmaceutical and recreational drug formulations containing the same. The compounds may be produced in vitro or in vivo using a biosynthetic system which comprises cells...
|
|
WO/2022/148351A1 |
The present invention relates to the field of bioengineering and medical chemical production. In particular, provided is a polynucleotide comprising a coding sequence of toluene dioxygenase. Also provided are an expression cassette, a ve...
|
|
WO/2022/140507A1 |
Disclosed herein are methods for synthesizing or functionalizing organic compounds using a library of biocatalysts. The methods include separately admixing a reactant and an aqueous solvent with each biocatalyst in a library of biocataly...
|
|
WO/2022/138969A1 |
The present invention addresses the problem of providing: a mutant L-pipecolic acid hydroxylase for producing cis-5-hydroxy-L-pipecolic acid in a highly productive and highly selective manner by hydrating L-pipecolic acid; and a novel me...
|
|
WO/2022/138909A1 |
[Problem] The present invention provides: an equol clathrate having improved solubility in water; an equol-absorbent composition containing the equol clathrate; a production method for the clathrate; and an equol-absorbent composition co...
|
|
WO/2022/131130A1 |
The present invention relates to a polynucleotide described in any one of (a1) to (a5) mentioned below. (a1) A polynucleotide which comprises the nucleotide sequence represented by SEQ ID NO: 1; (a2) a polynucleotide which comprises a nu...
|
|
WO/2022/127310A1 |
Provided in the present invention is a method for preparing (S)-2-(3-pyridine)-pyrrolidine, and a chiral 2-pyridine pyrrolidine compound is prepared by means of using an imine reductase (IRED) or an engineering bacterium expressing the e...
|
|
WO/2022/127481A1 |
Provided are a recombinant Saccharomyces cerevisiae capable of biosynthesizing cannabichromenic acid and a method for biosynthesizing cannabichromenic acid by means of using said cellular organism. The method comprises: firstly, overexpr...
|
|
WO/2022/125645A1 |
Described herein are non-natural olivetolic acid cyclases (OAC) variants capable of forming a 2,4-dihydroxy-6-alkylbenzoic acid from a 3,5,7-trioxoacyl-CoA or a 3,5,7-trioxocarboxylate substrate at a greater rate than a wild type or cont...
|
|
WO/2022/125960A1 |
The present disclosure provides recombinant host cells comprising a pathway capable of producing a cannabinoid and/or cannabinoid precursor, wherein the pathway comprises an enzyme AAE from a source organism other than Cannabis sativa, s...
|
|
WO/2022/120490A1 |
The present disclosure relates to cytochrome P450 monooxygenases capable of oxidizing a monoterpenoid indole alkaloid (MIA) substrate and methods and uses thereof. The substrate may be a camptothecinoid, an evodiaminoid or an ellipticino...
|
|
WO/2022/116948A1 |
Disclosed is a method for producing at least one target product from glycolic acid under the action of an enzyme. In order to solve the key problem of losing 25% fixed organic carbon during the recycling process of natural glycolic acid ...
|
|
WO/2022/109736A1 |
Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequenc...
|
|
WO/2022/110916A1 |
A method for preparing a nitrogen-containing heterocyclic compound and a derivative thereof by means of an enzymatic-chemical cascade method, comprising: reacting an alcohol, an amine, an alcohol dehydrogenase, a flavin molecule and a co...
|
|
WO/2022/106522A1 |
Enzyme mutant with squalene-hopene-cyclase activity, selected from mutants of a wild-type enzyme comprising an amino acid sequence selected from SEQ-ID No: 1 to 3 or an amino acid sequence derived therefrom with a degree of sequence iden...
|
|
WO/2022/104460A1 |
The present disclosure relates generally to methods, isolated polypeptides and polynucleotides, expression vectors, and host cells for the production of olivetolic acid and phytocannabinoids. A method of producing olivetolic acid (OVLa) ...
|
|
WO/2022/104475A1 |
Disclosed are biosynthesized novel nitrilated psilocybin derivative compounds and pharmaceutical and recreational drug formulations containing the same. The compounds may be produced by reacting a reactant psilocybin derivative with a ni...
|
|
WO/2022/105482A1 |
Disclosed is a method for preparing nicotine of a high optical purity, wherein biological enzyme catalysis technology is used to achieve directional reduction of an intermediate product, myosmine; the intermediate product myosmine can be...
|
|
WO/2022/099424A1 |
Provided herein are microorganisms for producing substituted tryptamines and cell cultures thereof, the microorganisms comprising at least one exogenous nucleic acid molecule that encodes at least one substituted tryptamine biosynthetic ...
|
|
WO/2022/101306A1 |
The present invention relates to a process for the production of a compound of Formula (I), wherein the process comprises the step of reacting a plant extract having prenyltransferase activity with a compound of Formula (II) and geranyl ...
|
|
WO/2022/098133A1 |
The present invention relates to a Streptomyces sp. strain having an antiviral efficacy and an antiviral composition including same.
|
|
WO/2022/088528A1 |
Provided are a transaminase mutant and the use thereof in the preparation of a sitagliptin intermediate. The mutant is obtained by means of substituting tyrosine at position 74 with proline, glutamic acid at position 228 with aspartic ac...
|
|
WO/2022/094075A1 |
Described herein are compositions and methods for infusing CBD into a plant and/or plant part. The compositions and methods can be used, for example, to produce vegetables and fruits comprising a quantity of CBD infused therein as a more...
|
|
WO/2022/089572A1 |
The present disclosure relates to synthesis of enantiomerically rich key drug intermediates as a means for manufacturing of thiocarbamate derivatives as A2A adenosine receptor (A2AR) inhibitors. More particularly, the present disclosure ...
|
|
WO/2022/083007A1 |
Provided are a fermentation method for producing high-content Bacillus coagulans spore probiotics by means of using cocoa powder and the use thereof. By means of adding an appropriate amount of cocoa powder to Bacillus coagulans for soli...
|
|
WO/2022/079137A1 |
The present invention relates to formation of highly enriched (R)-pantolactone from conversion of keto-pantolactone in a bio-catalytic process using NADPH- dependent enzymes in the presence of NADH as co-factor.
|
|
WO/2022/081615A1 |
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro. Specifically, the disclosure is directed to a prenyltransferase variant, a chimeric prenyltransferase comprisi...
|
|
WO/2022/073331A1 |
Provided are a nitrilase mutant and use thereof in catalytic synthesis of 2-chloronicotinic acid. The nitrilase mutant has an amino acid sequence shown as SEQ ID NO: 4, and is obtained by mutating tryptophan (Trp) at the position 167 of ...
|
|
WO/2022/072374A1 |
Disclosed herein, inter alia, is a light-controlled bioorthogonal tetrazine ligation.
|
|
WO/2022/069610A1 |
The present invention relates to polypeptides capable of modifying the C8-atom of deoxynivalenol and methods (e.g., for detoxifying mycotoxins) based thereon. The present invention further relates to compositions, kits, transgenic plants...
|
|
WO/2022/066534A1 |
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using...
|
|
WO/2022/066754A1 |
This disclosure concerns a genetic platform for obtaining modified Cannabis plant materials exhibiting desirable novel chemotypes and agronomic traits, for example, by modulating the cannabinoid biosynthetic pathway.
|
|
WO/2022/066007A1 |
The invention relates to the field of protein engineering and biocatalysis, more in particular to novel polypeptides having peroxygenase activity, and to methods and uses related thereto. Provided is a method for the production of melani...
|
|
WO/2022/060593A1 |
Fermented extracts containing natural lactones and hydroxy fatty acids are extracted from mixed culture fermentations of non-hydrolyzed vegetable oils.
|
|
WO/2022/057223A1 |
A benzothiazole meroterpenoid compound derived from deep sea fungi and a derivative thereof, and a preparation method therefor and the use thereof in the preparation of an anti-tumor drug. The benzothiazole meroterpenoid compound is a co...
|
|
WO/2022/052191A1 |
A histidinol-phosphate aminotransferase mutant, engineering bacteria and the use of the histidinol-phosphate aminotransferase mutant in the production of indole-3-pyruvic acid. A histidinol-phosphate aminotransferase gene is derived from...
|
|
WO/2022/054081A1 |
The present disclosure provides a bioprocess for the simultaneous production of Polyhydroxybutyrate (PHB) and Violacein pigment in a single fermentation using a Himalayan bacterial isolate Iodobacter sp. PCH 194, having accession number ...
|
|
WO/2022/047580A1 |
Disclosed are hydroxy lated psilocybin derivative compounds of formula (I) and pharmaceutical and recreational drug formulations containing the same. The compounds may be produced synthetically or biosynthetically.
|
|
WO/2022/051761A2 |
Variants of Squalene Hopene Cyclase (SHC) isolated from Gluconobacter morbifer are provided as is a method for using the variant G. morbifer SHC to biocatalytically convert homofarnesol to ambrox.
|
