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WO/2014/080666A1 |
A diterpene compound represented by formula (VII) is a novel diterpene compound having an excellent skin-whitening effect. The present invention provides: a skin-whitening agent comprising a novel diterpene compound; and a method for pro...
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WO/2014/056006A1 |
The invention relates to enzymes for transforming ergopeptines, in particular by means of hydrolytic cleavage. Said enzymes are α/ β hydrolases which are hydrolytically cleaved in the cyclol ring of the ergopeptines for the transformat...
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WO/2014/056007A2 |
The invention relates to an enzyme preparation for transforming ergopeptines, containing at least one α/ß hydrolase which is hydrolytically cleaved in the cyclol ring of the ergopeptines and at least one amidase transforming the degrad...
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WO/2013/006953A9 |
Polypeptides having alkanoyl-CoA activity have been identified and characterized, as have nucleic acids encoding these polypeptides. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. ...
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WO/2014/036395A1 |
The invention provides a series of bioactive small molecules that target expanded r(CGG) repeats, termed r(CGG)exp, that causes Fragile X-associated Tremor Ataxia Syndrome (FXTAS). The compound was identified by using information on the ...
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WO/2014/029498A1 |
The present invention provides dimers and sulfonyl dimers of the compound of formula (I) having antibacterial activities.
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WO/2014/015256A2 |
Provided herein are enzymatic methods for oxidation of 5-hydroxymethylfurfural (HMF) and HMF derivatives.
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WO/2014/005408A1 |
Provided in the present invention are antibiotic Tetrathiazomycin A and the preparation method thereof and the use in the preparation of an antitumour drug. The structural formula of Tetrathiazomycin A is shown as formula (I). The presen...
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WO/2013/190341A1 |
The present invention relates to an enantioselective enzymatic process for the preparation of an optically active 3-hydroxypiperidinecarboxylic acid derivative.
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WO/2013/173784A1 |
The invention provides new processes for making and purifying salts of hydroxylated cyclopentapyrimidine compounds, which are useful as AKT inhibitors used in the treatment of diseases such as cancer, including the monohydrochloride salt...
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WO/2013/169725A2 |
The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proli...
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WO/2013/169610A1 |
The present invention is directed to processes for preparing an intermediate for a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorder...
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WO/2013/162478A1 |
There is provided a method of degrading a heterocyclic aldehyde compound comprising the step of treating the heterocyclic aldehyde compound with Enterobacter sp. microorganisms. There is also provided a method of degrading a carboxylic a...
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WO/2013/155868A1 |
Provided in the present invention is a method for increasing the yield of total flavonoids in Ganoderma lucidum mycelium with an expansin, comprising the steps of: (1) inoculating strains of Ganoderma lucidum into the PD liquid fermentat...
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WO/2013/153554A1 |
The present invention provides a novel method for producing rapamycin by submerged fermentation which comprises cultivating Streptomyces hygroscopicus (CBS 773.72) and mutants thereof. The present invention provides a high yielding mutan...
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WO/2013/143184A1 |
Provided is a streptomyces (Streptomyces sp.) strain SCSIO 03032, preserved in China Center for Type Culture Collection on July 18, 2011 with the preservation number CCTCC NO: M 2011258. The streptomyces (Streptomyces sp.) strain SCSIO 0...
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WO/2013/139987A1 |
The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1'R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetr
ahydrospiro[indoline-3,1'-pyrido[3, 4-b]indol]-2-one ...
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WO/2013/132118A1 |
The present invention relates to an isolated polynucleotide comprising ectoine- and hydroxyectoine-producing genes, preferably with at least two copies of the gene that encodes the ectoine hydroxylase enzyme, expression of which is direc...
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WO/2013/129661A1 |
The present invention provides a chroman derivative represented by general formula (I), which enables the production of an SMTP compound that has a desired structure. In the formula, each of Y1 and Y2 independently represents a hydrogen ...
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WO/2013/127915A1 |
Recombinant microbial cells and methods for producing melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an L-tryptophan ...
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WO/2013/127356A1 |
Provided are a preparation method of (R) - praziquantel and an intermediate thereof. 1-alkylcarbamoyl-3，4-dihydroisoquinoline or 1-ester-3，4-dihydroisoquinoline are used as starting materials of the preparation method; the starting m...
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WO/2013/127914A1 |
Recombinant microbial cells and methods for producing 5-hydroxytryptophan (5HTP) using such cells are described. More specifically, the recombinant microbial cell comprises an exogenous gene encoding an L-tryptophan hydroxylase, and mean...
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WO/2013/103246A2 |
The present invention relates to: a recombinant microorganism producing quinolinic acid which expresses a fusion protein in which L-aspartate oxidase and quinolinate synthase are linked by a linker; and a method for producing quinolinic ...
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WO/2013/097424A1 |
Provided are a marine streptomyces sp., a compound of pyranosesquiterpenes and a preparation method and the use thereof. Streptomyces sp. SCSIO 01689 was deposited in the China Center for Type Culture Collection (CCTCC) on July 18, 2011,...
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WO/2013/095175A1 |
The invention relates to biotechnological industry, specifically to obtaining the substance of medicinal preparation stepharine sulfate out of the cell culture of Stephania glabra plant, and a method of quantitative determination of step...
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WO/2013/090837A2 |
This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups,...
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WO/2013/075676A1 |
The microorganism strain Rhizobium radiobacter R89-1 CCM 7947, capable of hydroxylating codeine in position 14 to 14-hydroxycodeine of formula (2) and 14-hydroxycodeinone of formula (3) with 100% conversion of starting codeine of formula...
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WO/2013/074650A1 |
The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypept...
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WO/2013/068917A1 |
The present application relates to a process for the preparation of lactones by enzymatic oxidation of lactols. The lactones, produced thus may be useful for the synthesis of statins, including but not limited to, cerivastatin, pitavasta...
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WO/2013/067719A1 |
Provided is a bioengineering strain for producing a new microbial fungicide and the use thereof, wherein the bioengineering strain is obtained by transforming a phzH gene recombinant expression plasmid into a strain producing phenazine-1...
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WO/2013/065383A1 |
A compound represented by structural formula (A) or a salt thereof. The compound or the salt thereof is produced suitably from a microorganism belonging to the genus Saccharothrix and can be used suitably as a prostaglandin production in...
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WO/2013/067432A1 |
The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. ...
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WO/2013/064687A2 |
The present invention belongs to the field of pharmaceutical industry and specifies the process for preparing clavulanic acid by using a microorganism, comprising the steps of providing a microorganism being capable of producing clavulan...
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WO/2013/061919A1 |
The purpose of the present invention is to provide: a novel compound useful as an anti-mold substance; and a method for producing the compound. The present invention relates to: a compound represented by formula (I0) (wherein R1 represen...
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WO/2013/059507A1 |
The invention provides isolated nucleic acid encoding one or more gene products that allow for degradation of caffeine and related structures, and for preparation of intermediates in that catabolic pathway. Further provided are methods o...
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WO/2013/058582A2 |
The present invention relates to a preparation method for an ansamycin glycoside or a non-benzoquinone geldanamycin glycoside having an ansamycin backbone using a glycosyltransferase, a non-benzoquinone geldanamycin glycoside, and a phar...
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WO/2013/041935A1 |
The present invention provides a process for the preparation of lycopene containing oleoresin and lycopene crystals for human consumption. The present invention provides an efficient process for the preparation of lycopene crystals from ...
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WO/2013/036787A2 |
Provided herein are cell-free systems for generating carbapenems, e.g., a compound of the Formula (I): or salts thereof; wherein (II), R1, R2, R3, R4, R5, and R6 are defined herein. Also provided are pharmaceutical compositions comprisin...
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WO/2013/023391A1 |
Disclosed are a Pseudonocardia sp. and a method for preparing deoxynyboquinone by the same. Pseudonocardia sp. SCSIO 01299 was deposited on July 18, 2011, at the China Center for Type Culture Collection (CCTCC), address: Wuhan University...
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WO/2013/017517A1 |
A process for the manufacture of (R)-(-)-1 -(2,4-dichloro-phenyl)-2-imidazole-1 -yl- ethanol (I) by biocatalytic asymmetric reduction of 1 -(2,4-dichloro-phenyl)-2-imidazole- 1 -yl-ethanone (II) is provided. The invention also provides a...
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WO/2013/003744A2 |
Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunc...
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WO/2013/002561A2 |
The present invention relates to a Kitasatospora sp. DG09 strain, to a tyrosinase produced from same, and to a method for producing 5,6-dihydroxyindole using same. More particularly, the present invention relates to the Kitasatospora sp....
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WO/2012/175570A1 |
The invention relates to a method for metabolic evolution of a variant of a natural small aromatic molecule product of a metabolic pathway, by somatic in vivo assembly and recombination of said metabolic pathway employing a gene mosaic o...
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WO/2012/171666A1 |
A method comprising the steps (a) contacting a hydrocarbon comprising a hydroxyl group with a biological agent having oxygen-dependent and cofactor-dependent carbohydrate oxidase activity in the presence of oxygen and carbohydrate oxidas...
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WO/2012/171966A1 |
The present invention relates to a method for the preparation of disaccharides and polysaccharides by means of the regioselective hydrolysis of monosaccharide units in the primary position.
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WO/2012/171070A1 |
The present invention relates to a method of producing carbamoyl phosphate, the method comprising reacting ammonia, ATP, bicarbonate and CO2, or a hydrated form thereof, in a composition in the presence of a carbamate kinase, wherein the...
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WO/2012/170793A1 |
Processes and methods for making biobased tetrahydrofuran products from renewable carbon resources are described herein.
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WO/2012/167350A1 |
There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid sid...
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WO/2012/170520A1 |
The present disclosure provides methods to produce substituted furans (e.g., halomethylfurfural, hydroxymethylfurfural, and furfural), by acid-catalyzed conversion of biomass using a gaseous acid in a multiphase reactor, such as a fluidi...
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WO/2012/166842A1 |
Methods and systems for increasing the yield and/or throughput of a product produced in a multi-step equilibrium pathway are described. Product yield and/or throughput is increased through supersaturation of a solubility-limited substrat...
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