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WO/2017/202193A1 |
Provided are applications of a recombinant ketoreductase in the preparation of (R)-3-quinuclidinol. The amino acid sequence of the recombinant ketoreductase is shown by any one of SEQ ID No.2, 4, 6, 8 and 10. A product is obtained in a r...
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WO/2017/203454A1 |
The invention relates to a method for obtaining an extract from a cell culture of Neem (Azadirachta indica). The suspended cell culture is subjected to cellular stress under conditions that promote the production of active metabolites su...
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WO/2017/197993A1 |
Provided are a Serratia liquefaciens ZMT-1 the collection No. of which is CCTCC NO:M2016170, and a method for producing Heliotropin by using the Serratia liquefaciens ZMT-1 strain or an enzyme produced by the Serratia liquefaciens ZMT-1 ...
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WO/2017/182542A1 |
A solid form of (-)-Ambrox formed by a bioconversion process.
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WO/2017/178624A1 |
The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with a...
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WO/2017/175064A1 |
A method for the bio-enzymatic synthesis of tetrahydrocannabivarin (THC-v), cannabivarin (CBV) and cannabinol (CBN) by contacting a compound according to Formula I with a cannabinoid synthase enzyme. The cannabinoids are produced in the ...
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WO/2017/167866A1 |
Described herein are recombinant microbial host cells comprising biosynthetic pathways and their use in producing oxidation products and downstream products, e.g., melatonin and related compounds, as well as enzyme variants, nucleic acid...
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WO/2017/165692A1 |
The present disclosure provides compounds linked with a saccharide-metal complex. The compounds are designed to protect organs by inducing acquired cytoresistance without causing injury to the organ, among other potential uses.
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WO/2017/155025A1 |
Provided is a method for producing compound (1) or (6) by optical resolution using a specific hydrolase. (In the formula, R represents a protecting group of a carboxy group, R1 and R2 each independently represent a hydrogen atom or a pro...
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WO/2017/152273A1 |
Methods that may be used for the manufacture of a class of chemical compounds known as terpenoid indole alkaloids, including tabersonine and catharanthine are provided. Compositions useful for the synthesis of terpenoid indole alkaloids,...
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WO/2017/155945A1 |
Methods and systems of cell-free enzyme discovery and optimization are provided.
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WO/2017/150304A1 |
Provided is a method for producing ergothioneine, the method being characterized in that microorganisms having the ability to produce ergothioneine are cultured and extracellularly produced ergothioneine is obtained, and the method being...
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WO/2017/144065A1 |
The present invention reports a method of producing complex guaianolides from the plant genus Thapsia. The invention comprises a temporary immersion bioreactor (TIB) and cultures conditions for mass micropropagation of Thapsia spp. The i...
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WO/2017/140909A1 |
The invention relates to methods for synthesizing sclareolide and related compounds by biocatalytic cyclisation of a polyunsaturated carboxylic acid compound, in particular homofarnesylic acid and related compounds. The invention also re...
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WO/2017/137606A1 |
The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may b...
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WO/2017/129914A1 |
The invention relates to a method for producing pigments by cells capable of photosynthesis, according to which said cells are cultivated in conditions suitable for the development thereof, in order to obtain a biomass, the method compri...
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WO/2017/107897A1 |
The invention discloses preparation methods and use of an indole alkaloid compound. The invention produces a structural-novel indole alkaloid compound by using Penicillium crustosum PRB-2 collected from the deep ocean of Prydz Bay, Antar...
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WO/2017/108861A1 |
The invention provides a method for producing a flavoured milk product, the method comprising the steps of: (a) providing milk source; (b) fermenting the milk source using at least one microorganism, to produce a fermented milk source ha...
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WO/2017/103221A1 |
The invention provides a genetically modified bacterium for production of thiamine; where the bacterium is characterized by a transgene encoding a thiamine monophosphate phosphatase (TMP phosphatase having EC 3.1.3.-) as well as transgen...
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WO/2017/100429A1 |
Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feeds...
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WO/2017/092197A1 |
Provided in the present invention is a method for the enzymatic resolution of an isavuconazole intermediate. Enantiomeric impurities in (2R,3S)-isavuconazole intermediate I are hydrolyzed to (2S,3S)-carboxylic acid by-product by nitrilas...
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WO/2017/084064A1 |
Provided is a use of an electronic olfactory device in on-line detection of a cyclohexanecarboxylic acid concentration during dolomycin fermentation. An optimization method for supplementing a precursor during the dolomycin fermentation ...
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WO/2017/076273A1 |
Provided is a method for synthesizing pyrroloquinoline quinine in vitro by utilizing bacteria cell disruption supernatant and adding a pyrroloquinoline quinine synthesis precursor-artificially synthesized polypeptide. The method comprise...
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WO/2017/068217A1 |
The invention relates to a method for producing polyhydroxyalkanoates and ectoine from cereal grain hydrolysates by means of saccharification and simultaneous fermentation. The method uses liquefied cereal grain and allows polyhydroxyalk...
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WO/2017/055573A1 |
The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compou...
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WO/2017/057730A1 |
The present invention addresses the problem of providing a novel method for suppressing the generation of hydroxy-L-proline and producing high-purity hydroxy-L-pipecolic acid efficiently and inexpensively. Provided is a method for genera...
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WO/2017/049751A1 |
Provided is a Dectomax fermentation production method on the basis of using an oxygen uptake rate (OUR) as a control parameter. In the fermentation production method, a two-stage OUR control strategy is used, the oxygen uptake rate (OUR)...
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WO/2017/050918A1 |
The invention relates to an acid composition, particularly an acid food composition, comprising at least one phycocyanin resistant to pH acid.
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WO/2017/052232A1 |
A recombinant Streptomyces avermitilis strain producing milbemycin, and a milbemycin production method using the same are provided.
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WO/2017/050853A1 |
Methods for producing anthocyanin by expression in a microorganism are disclosed including culturing of the microorganism under anthocyanin producing conditions, wherein the microorganism has an operative metabolic pathway including at l...
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WO/2017/046319A1 |
The present invention relates to an asymmetric process for providing N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)et
hyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (apremilast) or a pharmaceutically acceptable salt or...
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WO/2017/035656A1 |
Biocompatible block copolymer micelles for use in mucoadhesive drug delivery are provided. The micelles comprise a degradable hydrophobic polymer, a degradable synthetic hydrophilic polymer and a mucoadhesive polymer. The micelles are pa...
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WO/2017/036128A1 |
An alkaloid compound, preparation method thereof and use thereof as an antiviral agent against herpes simplex virus type 1 (HSV-1). The preparation comprises: first performing strain fermentation and culturing of a fungus, Scopulariopsis...
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WO/2017/030668A1 |
The present invention provides methods of method of synthesizing 2,5-furan dicarboxylic acid (FDCA) and FDCA precursor molecules. The methods involve performing a chemical dehydration reaction on a gluconic acid derivative in the presenc...
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WO/2017/030503A1 |
The present invention relates to the field of fermentation biotechnology, more particularly to methods for the fermentative production of massoia lactone by Aureobasidium species.
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WO/2017/026173A1 |
The purpose of the present invention is to provide a method for producing selenoneine with which it is possible to produce selenoneine on an industrial scale because selenoneine can be produced at a higher yield than in the prior art. Th...
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WO/2017/022846A1 |
According to the present invention, pitavastatin calcium is safely produced at low cost with high yield and high selectivity in an industrial scale. This method for producing pitavastatin calcium is characterized by comprising a step (i)...
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WO/2017/005784A1 |
The present invention relates to a method for the stereo-selective production of pentostatin comprising an enzymatic transglycosylation reaction between 6,7-dihydroimidazo-[4,5-d]-[1,3]diazepin-8(3H)-one and a 2'-deoxyribonucleoside, fol...
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WO/2016/209883A1 |
Provided herein are non-naturally occurring microbial organisms having biosynthetic pathways for production of target products and one or more genetic modifications that reduce a byproduct of the biosynthetic pathway. Compositions of tar...
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WO/2016/201536A1 |
The present invention relates to a biotransformation method for transforming phenolic compounds from soy milk into bioactive isoflavones and equol, with a high yield and production volume, for use in the biotechnological field, mainly in...
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WO/2016/202858A1 |
The present invention relates to processes for the formation of furandicarboxylic acid (FDCA), in particular 2,5-furandicarboxylic acid (2,5-FDCA), and mono- and diester derivatives thereof, via a multistep biocatalytic oxidation reactio...
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WO/2016/202875A1 |
The present invention relates to processes for the formation of pyridinedicarboxylic acid (PDCA), in particular, 2,4-pyridinedicarboxylic acid (2,4-PDCA) and 2,5- pyridinedicarboxylic acid (2,5-PDCA), and mono- and diester derivatives th...
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WO/2016/202616A1 |
The invention relates to a method for obtaining at least one organic target product and biogas. The method is characterised in that, a) an organic substrate is fed into an aerobic fermentation process; b) during said anaerobic fermentati...
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WO/2016/198564A1 |
A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an ...
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WO/2016/198623A1 |
A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.
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WO/2016/194845A1 |
The purpose of the present invention is to provide a monascus dye having improved lightfastness and suppressed fading due to light exposure. In the monascus dye production process, a dye component shown by general formula (1) is generate...
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WO/2016/179296A1 |
Methods and engineered yeast cells for generating a benzylisoquinoline alkaloid product are provided herein. A method comprises providing engineered yeast cells and a feedstock to a reactor. In the reactor, the engineered yeast cells are...
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WO/2016/170099A1 |
There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant ...
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WO/2016/171533A1 |
The present invention provides: a novel Pseudoalteromonas sp. M2 strain, which is a microorganism having excellent antibacterial material producing ability and isolated from an intestinal sample of Halocynthia roretzi; a pseudane-based c...
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WO/2016/170106A1 |
A method of isolating and purifying (-)-Ambrox from a reaction mixture comprising (-)- Ambrox and one or more of the compounds (II), (III) and (IV)
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