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WO/2020/233506A1 |
A method for improving the production of streptomyces polyketide compounds is provided. The method greatly improves the capability of the streptomyces polyketide compounds by strengthening a triacylglycerol decomposition pathway in strep...
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WO/2020/232553A1 |
The present disclosure relates generally to methods and cell lines for the production of phytocannabinoids, phytocannabinoid precursors or intermediates, or phytocannabinoid analogue. Methods for transformation of host cells, such as yea...
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WO/2020/234215A1 |
The present invention relates to a biological cell that can grow in the absence of biotin under aerobic conditions, comprising a BIO1 gene (i.e. CfBIO1), and preferably a BIO6, BIO2, BIO3, and BIO4 gene. The present disclosure additional...
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WO/2020/229516A1 |
Herein are provided microbial factories, in particular yeast factories, for production of strictosidine aglycone and optionally other plant-derived compounds. Also provided are methods for producing strictosidine aglycone in a microorgan...
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WO/2020/230833A1 |
The purpose of the present invention is to provide a novel compound which has the action of effectively enhancing the antifungal activity of an antifungal drug and which has a skeleton structure different from that of known pharmaceutica...
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WO/2020/221795A1 |
The present invention relates to microbial factories, in particular yeast factories, for production of ergothioneine. Also provided are methods for producing ergothioneine in a yeast cell, as well as useful nucleic acids, polypeptides, v...
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WO/2020/219859A1 |
Disclosed are trans-enoyl CoA reductase (TER) enzymes and nucleic acids encoding them. In some cases, the TER enzymes are non- natural, engineered trans-enoyl CoA reductase. TER enzymes were shown to catalyse the conversion of 5-carboxy-...
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WO/2020/219863A1 |
Disclosed are biosynthetic methods and engineered microorganism that enhance or improve the biosynthesis of hexamethylenediamine, caproic acid or caprolactam. The engineered microorganisms include selected aldehyde dehydrogenase activity.
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WO/2020/212453A1 |
The invention relates to the use of an aldolase when carrying out a process comprising multiple successive crossed aldol reactions.
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WO/2020/211013A1 |
Disclosed are a monooxygenase mutant and use thereof. The amino acid sequence of the monooxygenase mutant is an amino acid sequence obtained by mutating the amino acid sequence as shown in SEQ ID NO: 1. The mutation comprises at least on...
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WO/2020/206051A1 |
Described herein is a method for producing indole-3-propionic acid and other indole derivatives via bacterial fermentation and compositions of the same. The method comprises adding bacteria Clostridium sporogenes ATCC15579 having a nucle...
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WO/2020/192560A1 |
The present invention discloses a chiral isoquinoline carboxylic acid (Ⅰ) and a preparation method thereof, the preparation method includes: reacting the racemate of isoquinoline carboxylate in an aqueous buffer solution under the cata...
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WO/2020/185626A1 |
Provided herein, among other things, is an engineered non-plant cell that produces a tropane alkaloid product, a precursor of a tropane alkaloid product, or a derivative of a tropane alkaloid product. A method for producing a tropane alk...
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WO/2020/177568A1 |
The present invention relates to an LL-D49194α1 analog, a preparation method therefor and an application thereof. Specifically, provided by the present invention is a deglycosylated and demethylated LL-D49194α1 analog. The obtained LL-...
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WO/2020/176958A1 |
The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, an...
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WO/2020/176998A1 |
Provided herein are methods and compositions for producing cannabinoids and other metabolites in a host cell.
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WO/2020/177390A1 |
A method for preparing an L-ergothioneine-containing cosmetic stock solution by means of fermenting Hericium erinaceus, the method comprising the following steps: step 1: inoculating Hericium erinaceus hyphae into a liquid seed culture m...
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WO/2020/173977A1 |
A method for making 2-oxygenated decalins form isoprenoids catalysed with a squalene-hopene cyclase (SHC). A fragrance composition comprising (2S*,4aS*,8aR*)-5,5,8a- trimethyldecahydronaphthalen-2-yl acetate.
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WO/2020/173453A1 |
Disclosed is a method for resolving an optical isomer from a racemate by means of electrodialysis. Specifically, an electrodialysis technique is used in an enzymatic resolution process, mainly in the separation of products after enzymati...
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WO/2020/172438A1 |
The present invention provides for a genetically modified fungal host cell capable of producing indigoidine, wherein the host cell comprises a non-ribosomal peptide synthetase (NRPS) that converts glutamine to indigoidine.
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WO/2020/165178A1 |
The invention relates to a recombinant yeast modified to be capable of producing eriodictyol and/or luteolin and to the use thereof to produce eriodictyol and/or luteolin.
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WO/2020/165882A2 |
The present invention relates to a method of producing high-purity 2-pyrone-4,6-dicarboxylic acid (PDC), and a method of producing an intermediate for same, the methods comprising the steps of: 1) producing terephthalic acid (TPA) from P...
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WO/2020/165182A1 |
The invention relates to a recombinant microorganism modified to be capable of producing diosmetin and/or hesperetin and to the use thereof to produce diosmetin and/or hesperetin.
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WO/2020/165189A1 |
The present invention relates to a recombinant microorganism modified to be capable of producing diosmin and hesperidin and to the use thereof for producing diosmin and/or hesperidin.
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WO/2020/162442A1 |
Provided are: a novel compound having antibacterial activity; and a method for producing the same. The present invention relates to a compound represented by formula (I), or a salt or ester thereof.
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WO/2020/163378A1 |
The inventive technology includes novel systems, methods, and compositions for the generation of water-soluble short-chain fatty acid phenolic compounds, preferably cannabinoids, terpenes, and other volatile compounds produced in Cannabi...
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WO/2020/161280A1 |
The present invention relates to a method for culturing unicellular red algae (URA) optimized for the valorization of culture products, both the biomass obtained and the phycocyanins which are extracted or the other culture products such...
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WO/2020/161682A1 |
The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica capable of producing cannabinoids and precursors thereof, particularly of producing cannabi...
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WO/2020/147031A1 |
Disclosed are a nitrile hydratase mutant, a genetically engineered bacterium containing the mutant, and the use thereof, falling within the technical field of enzyme engineering. According to the present invention, glycine at position 47...
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WO/2020/144371A1 |
The present invention relates to a recombinant microbial host cell comprising an operative biosynthetic metabolic pathway capable of producing one or more compounds selected from the group consisting of L-dopa, dopamine, (S)-Norcoclaurin...
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WO/2020/141230A1 |
The present invention relates to arecombinant microbial host cell producing a tetraketide or derivatives thereof from one or more substrates selected from cinnamoyl-CoA, p-Coumaroyl-CoA, Caffeoyl-CoA, Feruloyl-CoA, malonyl-CoA, sinapoyl-...
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WO/2020/137706A1 |
[Problem] The purpose of the present invention is to provide a new method for producing a cycloastragenol analog from astragaloside IV. {Solution] A method for producing a cycloastragenol analog that includes a contact step that brings a...
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WO/2020/134727A1 |
The present invention discloses a tetrapeptide compound, a preparation method and a use thereof. The tetrapeptide compound of the present invention is TP represented by formula 1, the preparation method thereof is firstly preparing an in...
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WO/2020/127208A2 |
The present disclosure concerns the large-scale manufacture of pharmaceutical compounds, and novel intermediates for use in the manufacture. International Patent Application WO2011154737 discloses morpholine pyrimidines useful for treati...
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WO/2020/128434A1 |
Disclosed herein is a method of reducing an aromatic nitro compound. In some embodiments the method comprises the step of (i) contacting an aromatic nitro compound with a catalyst, wherein, the catalyst comprises: (a) disproportionation ...
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WO/2020/122609A1 |
The present invention relates to the production of a novel compound usable as a main ingredient of a pharmaceutical composition for preventing or treating neurological disorders, the compound being 9-deoxo-31-O-demethyl-prolyl-FK506, 9-d...
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WO/2020/119828A1 |
Disclosed are an ectoine-producing Bacillus clausii ET01 and a method for producing ectoine by means of fermentation using the strain. The strain is deposited in the China General Microbiological Culture Collection Center (CGMCC) with th...
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WO/2020/122607A1 |
The present invention relates to the preparation of novel compounds 9-deoxo-31-O-demethyl-prolyl-FK506, 9-deoxo-36,37-dihydro-FK506, 31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-31-O-demethyl-36,37-dihydro-FK506, 9-deoxo-FK520, 31-O-demeth...
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WO/2020/117792A2 |
Provided herein are compounds of Formulas (la), (lb), (II) to (VIII), and salts thereof, and methods of making the same. Also provided herein are recombinant proteins useful in the production of compounds disclosed herein, polynucleotide...
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WO/2020/107629A1 |
A glycoside conversion method based on high-speed countercurrent chromatography, relating to the technical field of glycoside conversion, and specifically relating to a use of a high-speed countercurrent chromatograph in the bioconversio...
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WO/2020/108462A1 |
Provided is a monooxygenase of which the acid sequence is obtained by mutation of an amino acid sequence shown in SEQ ID NO: 2. The monooxygenase may be used for preparing chiral sulfoxide drugs and used for producing proton pump inhibit...
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WO/2020/107548A1 |
A highly efficient method for catalyzing the synthesis of sanguinarine and chelerythrine, comprising: from the known protopine-6-hydroxylase gene, dihydrobenzophenanthridine oxidase gene and cytochrome P450 reductase gene, by means of he...
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WO/2020/107783A1 |
Disclosed is a method for preparing (S)-1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid by means of multiple enzyme coupling, comprising using a racemate of 1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid or a racemate of 1, 2, 3...
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WO/2020/109776A2 |
A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1 -118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an...
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WO/2020/101371A1 |
The present invention relates to a dimeric stilbene production method using a callus culture medium of plant and, more particularly, to a dimeric stilbene production method using a callus culture medium of plant, and a composition, for p...
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WO/2020/094830A1 |
The invention provides a novel class of natural red azaphilone pigments: cavernamines and their hydroxyl-derivatives; as well as the organge/yellow precursor cavernine. Additionally, methods for their production by fermentation using a f...
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WO/2020/095008A1 |
The invention relates to the field of producing 4-hydroxymethyl-γ-butyrolactone (2H-HBO) from levoglucosenone (LGO). More particularly, the invention concerns an eco-compatible method for synthesising 2H-HBO optionally substituted at th...
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WO/2019/098598A9 |
The specification relates to a method for producing coumestrol by using cultured roots of leguminous plants and a method for preparing a leguminous plant extract having an increased coumestrol amount. A method according to one aspect of ...
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WO/2020/078837A1 |
A recombinant microbial host cell having improved in vivo conversion of reticuline and derivatives thereof (such as thebaine and/or oripavine) to relevant downstream opioids (such as neopinone, oripavine, northebaine, nororipavine or mor...
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WO/2020/078293A1 |
The present invention relates to the technical field of bioengineering and provides a method for efficient extraction of plant anthocyanidin. The method comprises steps of: hydrolyzing anthocyanin; using one of sodium bicarbonate or pota...
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