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WO/2023/061391A1 |
An Ansamitocin fermentation method, comprising fermentation culture and daily flow supplementation starting from the fermentation culture, wherein a supplement added by the daily flow supplementation comprises, in mass-volume ratio, 30-6...
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WO/2023/061237A1 |
Provided are a transaminase and a use thereof in the preparation of sitagliptin or an intermediate thereof. The amino acid sequence of the transaminase differs from the amino acid sequence shown in SEQ ID NO:1 in respect of the amino aci...
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WO/2023/052538A1 |
The present invention is concerned with the production of tulipalin A (α-methylene-γ- butyrolactone). Provided are methods for production of tulipalin A, recombinant cells or organisms for production of tulipalin A, enzymes needed for ...
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WO/2023/050516A1 |
Provided are a transaminase mutant and an application thereof. The transaminase mutant has an amino acid mutation based on a sequence shown in SEQ ID NO: 1, the amino acid mutation being a single position mutation from among W60Y, Y168A,...
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WO/2023/044556A1 |
Disclosed are novel aminated psilocybin derivative compounds and pharmaceutical and recreational drug formulations containing the same. The aminated psilocybin derivative compounds may be chemically synthesized.
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WO/2023/042081A1 |
The invention relates to a process to produce a (1r,4r)-4-substituted cyclohexane-1-amine [further referred as trans-4-substituted cyclohexane-1-amine] of formula (T), starting from a diastereomeric mixture of 4-substituted cyclohexane-1...
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WO/2023/040090A1 |
The present invention provides binaphtho r-pyrone compounds and an application thereof against plant anthracnose. Compounds having structures represented by formulas (1)-(4) or pharmaceutically acceptable salts thereof provided in the pr...
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WO/2023/043946A2 |
The disclosure relates to a method of making at least one cannabinoid comprising contacting at least one berberine bridge enzyme like (BBE-like) oxidase with at least one substrate, wherein the substrate comprises a cannabinoid precursor...
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WO/2023/019821A1 |
The present invention provides an azaphilone polymer compound, and a preparation method therefor and the use thereof. According to the present invention, muyocopronlaterale is fermented and cultured, and a fermentation product is separat...
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WO/2023/015712A1 |
The present invention relates to the technical field of biosynthesis, and in particular to a method for preparing S-nicotine. Amine oxidase is utilized to oxidize 1-methylpyrrolidine into corresponding imine, and then the imine and nicot...
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WO/2023/016387A1 |
Provided is a Bacillus amyloliquefaciens HDCC00252, the deposit number thereof being CGMCC No. 22781. Also provided is a method for producing 1-deoxynojirimycin by means of fermentation culture of the Bacillus amyloliquefaciens HDCC00252.
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WO/2023/010317A1 |
Disclosed is a method for inducing the production of maackiain by means of a Millettia suspension cell. By means of the method, in a scaled-up culture process of the Millettia suspension cell, by adding two or more of methyl jasmonate, p...
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WO/2023/015279A1 |
Provided are methods, prokaryotic host cells, expression vectors, and kits for the production of a methylated tryptamine or an intermediate or a side product thereof. In certain embodiments, the prokaryotic host cell is selected from the...
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WO/2023/010820A1 |
Disclosed is a method for purifying indole-3-lactic acid from a lactobacillus plantarum fermentation supernatant, utilizing a fermentation supernatant of lactobacillus plantarum ZJ316 having a deposit number of CCTCC NO: M 208077, and co...
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WO/2023/009954A1 |
The present invention provides improved solvents, methods, and systems for isolating purified cannabinoids from various sources. It has been found that C9 to C11 non-aromatic hydrocarbon solvents, and especially n-decane, work surprising...
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WO/2023/006995A1 |
The present invention relates to isolated nucleic acids, proteins or peptides, sets thereof, gene clusters, expression vectors, host cells, biosynthesis methods, a process of genetic engineering for optimizing product yield, biotechnolog...
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WO/2023/003350A1 |
The present invention relates to an oleaginous yeast Yarrowia lipolytica sur2 mutant strain and a method for producing and secreting, onto cell surfaces, sphingoid-based precursors, sphingosine and sphingolipids by using same. It has bee...
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WO/2023/288257A2 |
The present disclosure provides methods of producing substituted pyrazines. The methods comprise, in some embodiments, incubating a certain a-keto-acid, a certain aldehyde, and a pyruvate decarboxylase to form a certain a-hydroxyketone. ...
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WO/2023/275321A1 |
The present invention relates to a process to carry out two or more enzymatic reactions in a reaction medium, wherein the process comprises providing a system comprising at least two substantially homogeneous and colloidal populations of...
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WO/2022/271004A1 |
The present invention relates to a chemical compound of general formula (I) obtained from the sequential aerobic/anaerobic fermentation of an unrefined sugar substrate by means of the yeast Pichia membranifaciens, which exhibits a signif...
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WO/2022/268006A1 |
Disclosed in the present invention are an imine reductase mutant, and a method for preparing (S)-nicotine using the imine reductase mutant. The first objective of the invention is to provide an imine reductase mutant, for solving the pro...
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WO/2022/268093A1 |
Disclosed are a biological seed coating agent based on a trichoderma-bacillus sequential inoculation symbiotic culture fermentation liquor, and a preparation method therefor. According to the principle of synthetic biology, a symbiotic b...
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WO/2022/270684A1 |
The present invention relates to a method for extracting a low molecular weight proanthocyanidin by using cranberries and lactic acid bacteria. More specifically, the present invention may comprise the steps of: (S1) culturing and extrac...
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WO/2022/262456A1 |
The present invention relates to the technical field of Proanthocyanidin extraction, and in particular, to a method for extracting Proanthocyanidins from buckwheat hulls. The method specifically comprises: performing ultrasonic extractio...
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WO/2022/262591A1 |
A method for purifying ansamitocin P-3, comprising using a resin to adsorb an ansamitocin fermentation solution, using an organic solvent for resolution, collecting and concentrating a resolution solution, subjecting the resolution solut...
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WO/2022/263504A1 |
The present invention relates to a recombinant Bacillus host cell comprising a polynucleotide encoding a polypeptide of interest or encoding a polypeptide involved in the production of a compound of interest, wherein the host cell is def...
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WO/2022/260402A1 |
The present invention relates to: an atranorin biosynthesis gene derived from the lichen Stereocaulon alpinum; an Ascochyta rabiei) ATR-11 strain (accession number: KACC83048BP), having the gene introduced thereinto, for producing atrano...
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WO/2022/257686A1 |
Provided is the use of an immobilized transaminase in the preparation of sitagliptin and/or (R)-3-amino-1-morpholine-4-(2,4,5-trifluorophenyl)-1-butanon
e. The immobilized transaminase includes resin and a transaminase, which has an amin...
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WO/2022/253111A1 |
A method for using reduction to prepare (S)-nicotine, the method comprising: subjecting the enamine compound represented by formula I and/or the imine cation compound represented by formula II to a reduction reaction to obtain (S)-nicoti...
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WO/2022/248739A1 |
The present invention relates in a first aspect to an enzymatic method for the production of an L-glufosinate P-alkyl ester. This method is characterized by a step (c) in which an L-glufosinate P-alkyl ester carbamoylate is reacted to gi...
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WO/2022/251285A1 |
The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including comp...
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WO/2022/250557A1 |
The object of the invention is a process for the isolation and culture of strains, the strains, use thereof, media for culturing thereof and a form of scytonemin.
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WO/2022/246811A1 |
The present invention relates to the field of compound synthesis, and provides a polyketone compound and a preparation method therefor. In the present invention, solid fermentation is performed on Alternaria sp., and a series of separati...
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WO/2022/251327A1 |
Methods of cleaning an N-methyl-2-pyrrolidone (NMP) purification and recovery system having an NMP-containing chemical waste stream, a separation tower fluidically coupled with the chemical waste stream, a reflux drum fluidically coupled...
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WO/2022/247190A1 |
Provided is a high camptothecin yielding endophytic strain, which is selected from Alternaria tenuissima ZCMUKL-S1 having the preservation number CCTCC NO: M2021189, or Alternaria citricancri ZCMUKL-S2 having the preservation number CCTC...
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WO/2022/240071A1 |
The present invention relates to a recombinant microorganism for producing carnosine, histidine and beta-alanine and a method for producing carnosine, histidine and beta-alanine by using same and, more particularly, to: a recombinant mic...
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WO/2022/240114A1 |
The present invention relates to a food with improved flavor, nutrition, and color and a preparation method therefor and, more specifically, to a food which contains a compound selected from the group consisting of hemes, porphyrins, met...
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WO/2022/228297A1 |
Provided are a method for large-scale preparation of acyl/aroyl coenzyme A by an enzymatic method, i.e., using an acyltransferase to transfer acyl/aroyl from a cheap acyl/aroyl donor onto acyl/aroyl receptor coenzyme A, thereby achieving...
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WO/2022/227123A1 |
Disclosed in the present invention is a technological method for co-production of an L-ascorbic acid palmitate and biodiesel, comprising the following steps: performing primary enzyme-catalyzed reaction on an L-ascorbic acid and palm oil...
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WO/2022/226065A2 |
The present disclosure relates, at least in part, to the production of delta-lactones from fatty acid substrates via a batch fermentation method in an engineered microbe using a recombinant cytochrome P450 monooxygenase.
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WO/2022/226493A1 |
Provided are methods, host cells, transposons, transposomes, and kits for the optimized production of psilocybin or an intermediate or a side product thereof in a prokaryotic host cell. Also provided are methods, host cells, transposons,...
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WO/2022/226071A1 |
The present disclosure relates, at least in part, to the production of delta-lactones and gamma-lactones from fatty acid substrates (e.g., fatty acid substrates of C16-C25) via a batch fermentation method in an engineered microbe using a...
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WO/2022/220517A1 |
The present invention relates to: a composition for inhibiting the inflammation or aging of stem cells, containing, as an active ingredient, a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof; a method for inh...
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WO/2022/217705A1 |
Provided are a modified acid phosphatase and an application thereof. According to the mutant modified acid phosphatase PaAPasemu3, vitamin C is converted into vitamin C phosphate by expressing the modified acid phosphatase PaAPasemu3 in ...
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WO/2022/212246A1 |
Multi-enzyme systems attached to nanoparticles are effective to efficiently and controllably incorporate stable isotopes (such as deuterium) during the synthesis of small molecules. In one example, deuterium is incorporated into (+)-dihy...
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WO/2022/212917A1 |
Described in this application are proteins and host cells involved in methods of producing isoprenoid precursors and/or isoprenoids.
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WO/2022/204283A1 |
Provided herein, among other things, is an engineered non-plant cell that produces a tropane alkaloid product, a precursor of a tropane alkaloid product, or a derivative of a tropane alkaloid product by means of a complement of biosynthe...
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WO/2022/202961A1 |
The present disclosure addresses the problem of providing a technique whereby, in the process for detaching a methyl group in a methoxy group from a compound having the methoxy group in a side chain thereof to produce a demethylated comp...
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WO/2022/204246A1 |
This disclosure provides glucarate dehydratase enzymes useful for commercial scale production of 5-keto-4-deoxy glucaric acid (KDG) from glucaric acid. The produced KDG may be dehydrated to form furan dicarboxylic acid (FDCA). The disclo...
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WO/2022/192384A1 |
Provided herein are biosynthetic methods for producing lactones, such as macrocyclic lactones, from fatty acids. The lactones produced using and/or during the biosynthetic methods are also provided.
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