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WO/2022/051433A1 |
The present disclosure relates to the production of sesqui-cannabinoids and/or sesqui-cannabinoid precursors in either recombinant microorganism or in cell-free systems using a combination of enzymes, including farnesyl pyrophosphate syn...
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WO/2022/047579A1 |
Disclosed are halogenated psilocybin derivative compounds of formula (I), and pharmaceutical and recreational drug formulations containing the same. The compounds may be produced using a biosynthetic system which comprises cells comprisi...
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WO/2022/047559A1 |
The present disclosure provides recombinant microorganisms and methods for the anaerobic production of 2,4-furandimethanol from one or more carbon sources. The microorganisms and methods provide redox-balanced and ATP positive pathways f...
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WO/2022/043461A1 |
Disclosed is a method for production of oxygenated diterpenoid compounds, such as triptophenolide, triptonide and triptolide, by inserting genes encoding particular cytochrome P450 enzymes and expressing the genes in selected host cells ...
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WO/2022/046994A1 |
The present disclosure provides methods and compositions for producing artemisinic acid, dihydroartemisinic acid or artemisinin. In various aspects, the present disclosure provides enzymes, polynucleotides encoding said enzymes, and reco...
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WO/2022/045257A1 |
The present disclosure addresses the problem of providing an enzyme that dehydroxylates a hydroxyl group at the 9-position of a urolithin compound, said urolithin compound having the hydroxyl group at least at the 9-position. This proble...
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WO/2022/042650A1 |
A construction and application of recombinant Saccharomyces cerevisiae for synthesizing carminic acid, relating to the technical field of genetic engineering and biological engineering. The recombinant Saccharomyces cerevisiae CA-B2 capa...
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WO/2022/039250A1 |
This method of culturing human induced pluripotent stem cells comprises a step for inoculating human induced pluripotent stem cells in a medium at an inoculation density of 1.0×104-1.0×106 cells/cm2 in a culture vessel and two-dimensio...
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WO/2022/030493A1 |
The present invention provides: an agent and a method for forming zinc protoporphyrin IX under an aerobic condition using lactic acid bacteria belonging to the genus Lactococcus; an agent and a method for improving the color tone of a me...
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WO/2022/023464A1 |
A method for purifying a crude flavor or perfumery or cosmetic ingredient or intermediate, for example crude (-)-Ambrox, comprising a number of washing steps, the products of said method, and uses of said product.
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WO/2022/016254A1 |
The present disclosure relates generally to methods and cells for the production of substituted phytocannabinoids or substituted phytocannabinoid precursors in host cells that produce the phytocannabinoid or the phytocannabinoid precurso...
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WO/2022/018258A1 |
The present invention relates to a process for the preparation of the β-lactamase inhibitor clavulanic acid by using a microorganism, comprising a step of targeted modifying said microorganism. The present invention is further directed ...
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WO/2022/017523A1 |
Recombinant sorangium cellulosum for producing de-epoxidized epothilone B by fermentation, insertional inactivation of an epoK gene in an epothilone biosynthetic gene cluster in the recombinant bacteria, and a method for producing de-epo...
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WO/2022/013663A1 |
The present invention provides a 5-methylfolate producing microorganism which a) has been modified to have a decreased expression and/or activity of a polypeptide having both dihydrofolate synthase activity and folylpolyglutamate synthet...
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WO/2022/010043A1 |
A novel tricyclic dilactone compound, a strain producing same, a method for producing same, and a use thereof are provided. The tricyclic dilactone compound inhibits aggregation of amyloid-beta and tau proteins, inhibits apoptosis, has a...
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WO/2022/007542A1 |
Provided are a taxadiene synthase TcTS2, a encoding nucleotide sequence and use thereof. The amino acid sequence of TcTS2 comprises or consists of (a) an amino acid sequence set forth in SEQ ID NO: 1; or (b) a functional homologous seque...
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WO/2022/008503A1 |
The present invention provide scalable methods of producing newly identified atrorosin pigments, compositions comprising the pigments, lakes and dyes and uses thereof for colorings foods, such as dairy, meat substitutes or candy.
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WO/2022/007205A1 |
A method for increasing the content of intracellular heme in escherichia coli, comprising: knocking out a gene mscS for encoding a small-conductivity mechanosensitive ion channel protein, knocking out a gene aroG for encoding 3-deoxy-ara...
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WO/2022/007145A1 |
A functional module SyKerMb capable of efficiently degrading poultry feather waste and synthesizing a novel hemeprotein is artificially designed and constructed by using a synthetic biology method. A recombinant vector of the functional ...
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WO/2022/008628A1 |
The present invention relates to the provision of an enzymatic method for the preparation of 2, 6-bis(hydroxymethyl) pyridine (Formula I) using as substrate 2,6-Dimethlypyridine (2,6-lutidene) and the multicomponent xylene monooxygenase ...
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WO/2022/002104A1 |
The present invention relates to the technical field of biological medicines, and in particular, to a diazeniumdiolate Schiff base copper complex with a novel structure and a preparation method therefor. Moreover, the present invention f...
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WO/2021/260057A2 |
The present invention is related to sustainable fermentation processes with increased efficiency and less environmental impact. Particularly, the present invention is related to a process wherein in one fermentation process two or more f...
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WO/2021/254927A1 |
The present inventio provides methods for producing biotin comprising cultivation of a genetically modified host cells comprising an operative metabolic pathway producing biotin comprising a transgene encoding a Type II biotin synthase (...
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WO/2021/256894A1 |
The present invention relates to any one novel compound selected from the group consisting of 9-deoxo-36,37-dihydro-prolylFK506, (9-deoxo-31-O-demethyl-36,37-dihydro-prolylFK506), 9-deoxo-prolylFK520, and (9-deoxo-31-O-demethyl-prolylFK5...
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WO/2021/253124A1 |
This invention relates to the extraction of psychoactive compounds from fungus for use in medicine. Raw fungus is dried and ground. The solvent used for extraction is methanol or a hydro-methanol mixture, an acidic hydro-methanol mixture...
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WO/2021/253794A1 |
The invention relates to a maytansine derivative, a synthesis method therefor and a use thereof. The invention constructs an integrative expression vector pSBT11-astC consisting an alanyl enzyme gene astC, realizing heterologous expressi...
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WO/2021/250192A1 |
The present invention relates to a method for separating biomass from a solution comprising bi-omass and at least one aroma compound. comprising providing the solution comprising bio-mass and aroma compounds. lowering the pH value of the...
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WO/2021/252335A1 |
An engineered bacterial strain expressing dehydrogenases capable of oxidizing D- sorbitol to 2-keto-gulonic acid is provided by the present invention. Methods of using same in a one-pot synthesis of L-ascorbic acid (vitamin C) are also d...
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WO/2021/249980A1 |
The present invention relates to a method of converting 3-keto-DON into 3-epi-DON, reducing the content of DON in a composition comprising DON or of reducing the toxicity of a composition comprising DON as well as a method for converting...
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WO/2021/241218A1 |
The purpose of the present invention is to provide a highly active promoter. A promoter that comprises DNA selected from among (a) to (c): (a) DNA that comprises the nucleotide sequence of SEQ ID NO: 1; (b) DNA that comprises a nucleotid...
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WO/2021/231623A1 |
Described herein are recombinant host organisms having an active pentose fermentation pathway and further comprising a heterologous polynucleotide encoding a non- phosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (G...
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WO/2021/223366A1 |
A Streptomyces antibioticus PPI-16 with the accession number of GDMCC NO: 60970. Active compounds produced thereby can inhibit multiple pathogenic fungi, including Colletrichum orbiculare, Colletotrichum capsica, Tobacco anthracnose, and...
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WO/2021/214278A2 |
The present invention relates to regioselective chemical and electrochemical processes for the preparation of an oxidized heterocyclic alpha-amino amide compounds. By applying specific catalysts or catalyst systems during chemical oxidat...
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WO/2021/214283A1 |
The present invention relates to a novel biocatalytic process for the stereoselective preparation of alpha amino amide compounds catalyzed by NHase enzymes. A further aspect of the invention relates to novel NHase enzymes as well as furt...
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WO/2021/209482A1 |
An enzyme-mediated method for the production of Amberketal and Amberketal homologues, the products of said method, and uses of said products.
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WO/2021/201700A1 |
The present invention generally relates to methods of producing one or more indole diterpene compounds in the epoxy janthitrem biosynthetic pathway and polynucleotides, polypeptides, expression constructs and host cells useful in the pro...
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WO/2021/193806A1 |
The purpose of the present invention is to provide a method for producing ambrein by which ambrein can be easily and efficiently obtained. This problem can be solved by a mutant tetraprenyl-β-curcumene cyclase in which aspartic acid t...
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WO/2021/193581A1 |
The present invention pertains to: a method for treating drainage water containing a furan compound; a microbial preparation used in said method; a high-density culturing method for microorganisms used in said method; and a method for pr...
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WO/2021/190632A1 |
Provided in the present invention are a hydroxylase gene F3'5'H, an encoding protein thereof, an expression vector containing an F3'5'H nucleotide sequence, and a transgenic cell line and host bacteria that contain the expression vector....
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WO/2021/191848A1 |
A semisynthetic method of preparing neosaxitoxin from cultures of the dinoflagellate Gymnodinium catenatum is described. The scalable method includes the reductive desulfonation of an unresolved mixture of toxin C3 and toxin C4 and mild ...
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WO/2021/180019A1 |
Provided is a method for synthesizing (S)-nicotine, comprising: under the condition of a coenzyme circulation system, by using a coenzyme as a hydrogen donor, and by using imine reductase as a catalyst, catalyzing and reducing myosmine t...
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WO/2021/183992A1 |
Compositions and methods having antiviral properties, such as for the prevention, treatment or providing nutritional or other benefits in animals, including humans and livestock, having or at risk of viral-mediated disorders. Methods may...
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WO/2021/183298A1 |
A chemoenzymatic process for the preparation of 2,5-furan dicarboxylic acid includes contacting D-glucose with (i) at least two enzymes selected from the group consisting essentially of galactose oxidase, pyranose 2-oxidase, glucarate de...
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WO/2021/178976A2 |
Disclosed herein are novel prenyltransferases for the production of cannabinoids, as well methods of making and using such prenyltransferases.
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WO/2021/177812A1 |
The present invention describes a method for obtaining indole acetic acid (IAA) by fermenting the strains Klebsiella variicola, Bacillus licheniformis, Bacillus velezensis, Enterococcus faecium and Bacillus amyloliquefaciens or combinati...
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WO/2021/168988A1 |
The present invention provides a synthesis method for a fluorine-containing chiral amine compound. The synthesis method comprises: reacting an amino donor with a fluorine-containing dihydroxy ketal compound under the catalysis of transam...
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WO/2021/168987A1 |
Provided is a method for synthesizing a chiral diamine compound. The synthesizing method comprises: converting a substrate represented by formula I into a formula I chiral diamine compound by using transaminases, wherein n=1-10, an R gro...
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WO/2021/164155A1 |
The present invention relates to a cryptotanshinone derivative, a preparation method therefor and an application thereof in resisting neuroinflammation and neuroprotection. The cryptotanshinone derivative has the structure as shown in fo...
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WO/2021/168445A1 |
The present invention provides for a genetically modified bacterial host cell capable of producing indigoidine, wherein the host cell comprises a non-ribosomal peptide synthetase (NRPS) that converts glutamine to indigoidine, and the bac...
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WO/2021/159828A1 |
Provided are an enzyme having an acyl group transfer function as well as a mutant and application thereof, an amino acid sequence of the acyltransferase being that of SEQ ID NO: 1, and same being able to perform acylation on Macrolactins...
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