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WO/2015/156739A1 |
The present disclosure provides for a polypeptide scaffold capable of identifying and developing polyketide synthase enzymes. Moreover, the polypeptide of the present disclosure is utilized in methods for screening to verify the activity...
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WO/2015/143381A2 |
The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of gul...
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WO/2015/140315A2 |
The present invention relates to a method for obtaining at least one microbial secondary metabolite or a derivative thereof, the method comprising the step of heterologous expression of at least one synthetase of said secondary metabolit...
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WO/2015/128552A1 |
The invention relates to a method for producing lactones from a strain of Aureobasidium pullulans. The invention is characterized in that the method includes the following steps, according to which: a preculture of the Aureobasidium pull...
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WO/2015/125849A1 |
Provided is a bacteriochlorophyl b-producing variant obtained by deleting the bciA gene and bchY and/or bchZ gene inherent to a photosynthetic bacterium which produces bacteriochlorophyl a, and performing a manipulation so as to express ...
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WO/2015/121488A1 |
A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolat...
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WO/2015/119261A1 |
The purpose of the present invention is to provide a novel process whereby rosuvastatin calcium and an intermediate thereof which each have a high purity can be efficiently produced at low cost. This process efficiently produces high-pur...
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WO/2015/113569A1 |
The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R- MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 ...
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WO/2015/103711A1 |
There is provided a method of preparing a benzylisoquinoline alkaloid (BIA) metabolite comprising: a. culturing a host cell under conditions suitable for protein production, including a pH of between about 7 and about 10 said host cell c...
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WO/2015/091851A1 |
The present invention relates to the preparation of Tiacumicin B from a Dactylosporangium or Actinoplanes strain capable of producing Tiacumicin B utilizing spray drying or freeze drying and further extraction of the dried powder.
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WO/2015/091943A1 |
The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-e...
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WO/2015/095298A2 |
The subject invention pertains to microorganisms comprising genetic modifications involving one or more target genes encoding: putrescine-ornithine antiporter (PotE), putrescine importer (PuuP), ATP-dependent polyamine transporter (PotAB...
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WO/2015/082978A1 |
The present invention relates to a method of producing sesquiterpene lactones of the thapsigargin family, the method comprising the steps of: (a) culturing plant cells of the genus Thapsia in a nutrient medium in a suspension cell cultur...
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WO/2015/081437A1 |
Methods that may be used for the manufacture of the chemical compound (R)- Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.
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WO/2015/078267A1 |
Provided is a transaminase and a use thereof. The transaminase has the amino acid sequences as shown in SEQ ID NO: 2 or 4, or has at least 80% identity to the amino acid sequences as shown in SEQ ID NO: 2 or 4, or has amino acid sequence...
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WO/2015/075048A1 |
The present invention relates to a new process for the preparation of ammeline and/or ammelide from melamine by a solid-to-solid reaction in an aqueous reaction mixture comprising a biocatalyst, wherein the biocatalyst comprises at least...
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WO/2015/066642A1 |
Host cells that are engineered to produce benzylisoquinoline alkaloid (BIAs) precursors, such as norcoclaurine (NC) and norlaudanosoline (NL), are provided. The host cells may have one or more engineered modifications selected from: a fe...
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WO/2015/055127A1 |
The present invention relates to an (R)-praziquantel preparation method, comprising steps of using (R,S)-tetrahydroisoquinoline-1-formate or salts thereof, or 1-(S)-tetrahydroisoquinoline-1-formate or salts thereof as a raw material to p...
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WO/2015/052849A1 |
The purpose of the present invention is to provide; a phycocyanobilin derivative having an activity of increasing the amount of collagen; and a method for producing the phycocyanobilin derivative. A novel phycocyanobilin derivative havin...
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WO/2015/048452A2 |
The present disclosure provides for methods of producing hydroxymethylfurfural (HMF) from fructose and other carbohydrates, novel invertase enzymes capable of catalyzing the dehydration of fructose to HMF, and methods of making the novel...
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WO/2015/046848A1 |
The present invention relates to a method for producing an L-ascorbic acid derivative using a cyclodextrin glucanotransferase mutant enzyme in an enzymatic production method of the ascorbic acid derivative. More specifically, a transgluc...
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WO/2015/035778A1 |
Disclosed are a method for preparing a benzopyran compound and uses in protecting against pulmonary fibrosis. The structural formula of the benzopyran compound is shown by formula (I), R1 being one selected from hydrogen, C1-C4 alkyl and...
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WO/2015/032911A1 |
Recombinant microbial cells and methods for producing 5HTP, melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an L-trypt...
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WO/2015/031441A2 |
Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical phosphorus or sulfur sources. Fermentation methods using the genetically engineered organisms are also described. Th...
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WO/2015/021561A1 |
Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivati...
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WO/2015/014031A1 |
The present invention relates to a biological preparation method of (S)-3-(dimethylamino)-1-(thiophene-2-radical)-1-propyl alcohol. According to the method, (S)-3-(dimethylamino)-1-(thiophene-2-radical)-1-acetone or salt thereof is used ...
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WO/2015/004015A1 |
The present invention relates to the biocatalyzed synthesis of enantiomerically pure (3R) and (3S)-methyl-1,2,3,4-tetrahydroquinoline. Said enantiomerically pure compounds are useful as chiral synthons in organic synthesis and, in partic...
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WO/2015/000327A1 |
A biosynthesis gene cluster of Streptomyces xiamenensis, a purpose, and a bacterial strain are provided. A base sequence of the gene cluster is shown in SEQ ID No.1, and the full base sequence has 5189 bases. Streptomyces xiamenensis CGM...
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WO/2015/001330A1 |
A process for producing alkyl R-lactate and alkyl S,S-lactyllactate is provided. The process comprises:(a) admixing (i) a first mixture comprising R,R-and S,S-lactide with (ii) a second mixture comprising a C1-C8 alkyl alcohol, the corre...
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WO/2014/209112A1 |
The invention is directed to a process for the preparation of 2,5- furandicarboxylic acid (FDCA) by fermentation comprising fermenting a suitable starting compound to produce an aqueous solution of a salt of FDCA having a pH of at least ...
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WO/2014/201596A1 |
Provided is a new Cellulosimicrobium cellulans strain. The microbium cellulans (Cellulosimicrobium cellulans) strain F16 is under strain preservation number CCTCC M 2013201. Also provided is an application of the strain, and the strain i...
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WO/2014/194551A1 |
Disclosed are a biosynthesis gene cluster of marinacarbolines (MCBs) and a use thereof. The nucleotide sequence of the gene cluster is as shown by positions 1-4222 of SEQ ID NO. 1, and comprises three genes: a gene mcbA responsible for t...
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WO/2014/172596A9 |
This disclosure describes biosynthesized compounds including anhydromevalonolactone and β-methyl-δ-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic ...
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WO/2014/180085A1 |
Provided is a biological preparation method for chiral N- protection peridol, in which N-protection piperidone is used as a substrate, and the substrate is subjected to an asymmetric reduction reaction in the presence of a reconstructed ...
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WO/2014/181000A1 |
The invention provides a process for producing myxopyronin and derivatives of myxopyronin by providing synthetic pathway enzymes in a microorganism or in vitro, e.g. extracellularly. Myxopyronin and derivatives of myxopyronin in the seco...
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WO/2014/177492A1 |
Process for production of (R)-3-Quinuclidinol by reduction of Quinuclidin-3-one with cofactor and oxidoreductase, characterized in that, the oxidoreductase comprises an amino acid sequence motif MQX1REX2X3WEA, wherein each of X1, X2, X3 ...
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WO/2014/176514A2 |
The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxy...
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WO/2014/174505A2 |
The present invention is directed to the preparation of nicotine comprising the enzymatic reduction of 4- (methylamino) -1- (pyridin-3-yl ) butan-1-one.
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WO/2014/165174A2 |
An isolated fungus having the imperfect stage of Nodulisporium is described. The isolated fungus produces at least one compound selected from the group consisting of 1, 8-cineole, and 1 -methyl- 1,4-cyclohexadiene. A method for producing...
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WO/2014/163301A1 |
Provided is a method for purifying quinolinic acid, comprising the steps of: preparing a fermentation solution containing at least one of quinolinic acid and a salt thereof; removing microbial cells from the fermentation solution; prepar...
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WO/2014/155214A1 |
The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula (III) and/or Formula (IV) and...
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WO/2014/154785A1 |
The invention relates to a method for stabilising a biomass of microalgae containing oxidation-sensitive metabolites selected from the group consisting of carotenoids (lutein, etc.), monounsaturated and polyunsaturated fatty acids (palmi...
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WO/2014/140786A1 |
A fed-batch fermentation method for production of bacteriochlorophyll a (Bchla) from Rhodovulum sulfidophilum, is provided wherein the growth medium contains an inorganic nitrogen compound as the nitrogen source and during fermentation t...
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WO/2014/145550A2 |
A corner bead for wallboard applications comprising a polymeric core having a bonding surface for bonding to wallboard wherein the bonding surface has applied thereto a water activated adhesive which is bonded to the polymeric core by a ...
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WO/2014/131995A1 |
A method for the enzymatic synthesis of diosmetin derivatives of formula (III):
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WO/2014/132902A1 |
Provided are: a compound represented by structural formula (1); a production method therefor; a microorganism capable of producing said compound; and a compound-containing composition, an anticancer agent, and an anti-Helicobacter pylori...
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WO/2014/131247A1 |
Provided is a method for synthesizing levo-praziquantel, comprising subjecting a chemically synthesized raceme or a certain enantiomer to a dynamic kinetic resolution catalyzed with a nitrile hydratase to produce an optically pure chiral...
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WO/2014/122109A1 |
The invention relates to enzymatic methods for preparing indigo and derivatives thereof, using peroxygenase and hydrogen peroxide.
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WO/2014/112387A1 |
The purpose of the invention is to provide a novel antitrypanosomal drug. The invention pertains to actinoallolides (A, B, C, D, and/or E), which are novel compounds produced by the actinomycete MK 10-036; to a method for producing said ...
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WO/2014/094462A1 |
The present invention provides a biological preparation method of (S)-3-methylamino-1-(2-thienyl)-1-propyl alcohol, wherein 3-methylamino-1-(2-thienyl)-1-acetone is used as a substrate; under a condition that a biocatalyst ketoreductase,...
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