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WO/2007/099107A1 |
A process for the production of an optically enriched oxazolidinone of the formula (2a) or (2b), by reacting an epoxide of the formula (1 ) with cyanate in the presence of halo- hydrin dehalogenase.
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WO/2007/097106A1 |
By using sclareol as a substrate, a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]-furan intermediate is efficiently produced. As a result of intensive studies with the aim of isolating and identifying a microorganism having a character...
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WO/2007/095696A1 |
The present invention relates to polyketide xanthones of the kibdelone class and their use as antibacterial and anticancer agents is described. Methods of preparing kibdelone compounds, pharmaceutical compositions containing them, and th...
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WO2006113147B1 |
Herein is disclosed a method of generating ascorbic acid from yeast transformed with a mannose epimerase. In a further embodiment, the yeast can be further transformed with a myoinositol phosphatase. In the method, the transformed yeast ...
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WO/2007/084808A2 |
Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of...
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WO2007028239B1 |
The isolation and identification of two O-methyltransferases from the hops plant (Humulus lupulus L.), designated as OMT1 (SEQ ID NO. 1) and OMT2 (SEQ ID NO. 3) is described.
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WO/2007/078263A2 |
Technical solution is related to industry production microorganism Streptomyces toxytricini CCM 7349 and method of lipstatin biotechnology preparation by this strain. Production strain listed above with use of two step vegetative inoculu...
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WO/2007/074060A1 |
The invention relates to a method for production of optically active (1S)-3-chloro-1-(2-thienyl)-propan-1-ol of formula (I), wherein 3-chloro-1 -(2-thienyl)-propan-1-one of formula (II) is reduced in a medium to give the compound of form...
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WO2007035693A9 |
Novel isonitrile biosynthetic enzymes isnA and isnB which together possess a catalytic activity of converting an amine-containing compound to an isonitrile-containing compound are described. The genes that encode such enzymes, recombinan...
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WO/2007/074070A1 |
The invention relates to a method for producing optically active alkanols of formula (I), in which n represents a whole number from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, c...
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WO/2007/068498A1 |
The invention relates to a process for the preparation of δ-lactones by reacting acetaldehyde and a substituted acetaldehyde in the presence of an aldolase, preferably a DERA from Escherichia coli, from Bacillus subtilis or from a Geoba...
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WO/2007/067698A2 |
The invention concerns a method having the steps of: combining an aqueous fermentation broth containing ansamitocins with a water-immiscible solvent and a water-soluble solvent to form an organic layer and an aqueous layer, wherein: (i) ...
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WO/2007/063866A1 |
An industrially advantageous process for producing a compound capable of inhibiting an HMG-CoA reductase and having an activity of decreasing the serum cholesterol level, which is characterized by using a protein comprising an amino acid...
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WO/2007/051651A1 |
Disclosed are strains of fungus Claviceps purpurea (Fr.) Tul., that produce a high content of total ergot peptide alkaloids and an amount of beta-ergokryptine greater than the amount of alpha-ergokryptine during parasitic growth on a cer...
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WO/2007/046943A2 |
The present invention relates to the production process of biotin by fermentation using genetically engineered microorganisms, including Escherichia coli and Pseudomonas mutabilis, and DNA sequences and vectors to be used in such process.
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WO/2007/040082A1 |
Disclosed is a composition for treatment of nephritis which contains a triprenyl phenol compound as an active ingredient. The composition preferably contains a triprenyl phenol compound represented by the general formula (I) below as an ...
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WO/2007/039816A2 |
The present invention relates to improved fermentation processes for the preparation of tacrolimus or a salt or derivative thereof by culturing a microorganism capable of producing tacrolimus or a salt or derivative thereof under submerg...
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WO/2007/028602A1 |
The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the fu...
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WO/2007/028609A1 |
The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the fu...
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WO/2007/030662A1 |
Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selec...
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WO2006134623B1 |
The present invention describes a method for increasing the survival of the bacteria of Rhizobium genus, comprising the steps of: making the bacteria to grow in a chemically defined medium; keeping the bacteria in growth stationary phase...
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WO/2007/018194A1 |
It is intended to provide a method for producing cercosporamide, characterized by culturing a bacterium belonging to the genus Lachnum and/or a bacterium belonging to the genus Pseudaegerita and collecting cercosporamide from the culture...
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WO/2007/015511A1 |
A novel D-amino acid oxidase isolated and purified from Candida intermedia; a gene encoding the D-amino acid oxidase; a recombinant plasmid carrying the gene; a transformant having the D-amino acid oxidase gene introduced therein; a meth...
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WO/2007/014971A2 |
The invention relates to genes involved in the biosynthesis of thiocoraline and to the heterologous production of same. According to the invention, the cluster of genes responsible for the biosynthesis of thiocoraline was identified and ...
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WO/2007/010944A1 |
The invention relates to a method for producing an optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid ester, characterized by allowing an enzyme source having an activity of stereoselectively reducing a 2-(N-substituted...
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WO/2007/007986A1 |
Provided is S-adenosylmethionine-6-N-lysine-methyltransferase obtained from Neυrospora crassa, a polynucleotide encoding the same, a vector and host cell containing the polynucleotide, and a method of producing trimethyllysine by cultur...
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WO/2007/007399A1 |
Compounds having an anti-MRSA activity and having a skeleton and action mechanism different from those of existing drugs, which are useful as a novel antimicrobial agent. Conventionally, vancomycin is used as a drug for MRSA. However, re...
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WO/2007/003574A1 |
A method for making dihydroxyacetone phosphate (DHAP) comprising treating dihydroxyacetone with a bacterial acid phosphatase in the presence of pyrophosphate. The invention further pertains to a method for making, preferably in one pot, ...
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WO/2006/136521A1 |
A process is described for the preparation of escitalopram and the pharmaceutically acceptable salts thereof starting from 5-cyanophthalide by a process which provides an enantioselective enzymatic deacylation reaction of a complex of th...
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WO/2006/134482A1 |
A novel process for producing atrovastatin, pharmaceutically acceptable salts thereof, and intermediates thereof using an aldolase is described. Compounds so prepared are useful as inhibitors of the HMG-CoA reductase and may thus be used...
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WO/2006/134374A2 |
There is provided a method for producing L-ascorbic acid (vitamin C) in which the enzymes tagatose epimerase and fucose isomerase are co-incubated with a micro-organism able to convert L-galactose to L- ascorbic acid. The micro-organism ...
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WO/2006/133332A2 |
A process for the enzyme-catalyzed preparation of cyclic ester oligomers from dicarboxylic acids and/or dicarboxylic acid derivatives and diols, hydroxycarboxylic acids and/or hydroxycarboxylic acid esters, and/or linear ester oligomers ...
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WO/2006/131098A2 |
The invention relates to a method for producing rhizoxin and derivatives of rhizoxin. The aim of the invention is to produce novel micro-organisms that synthesise rhizoxin or derivatives of rhizoxin, and to provide a method for producing...
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WO/2006/130657A2 |
The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula (Ib).
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WO/2006/126498A1 |
The invention relates to a novel amino group transferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also rel...
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WO/2006/126723A1 |
A genetically modified microorganism capable of directly producing a 16-hydroxylated macrolide compound; and a process for producing a 16-hydroxylated macrolide compound using the microorganism. Specifically, a genetically modified micro...
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WO/2006/123007A1 |
The invention relates to a genetically-modified micro-organism which can be used to produce 6HNA (6-hydroxynicotinic acid) from NA (nicotinic acid), based on the genetic modification of one or more genes of the nic route, which may be of...
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WO/2006/120813A1 |
An object of the invention is to provide a method capable of producing D-glucuronic acid and D-glucuronolactone easily and safely in high yield and at low cost. The invention provides a method for producing glucuronic acid and/or glucuro...
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WO/2006/116487A2 |
Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing ...
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WO/2006/109198A2 |
The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific glycidyl ether hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, ve...
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WO/2006/101073A1 |
[PROBLEMS] To search a substance capable of inhibiting the induction of the expression of GRP78 to find a novel anti-cancer agent. [MEANS FOR SOLVING PROBLEMS] A novel compound represented by the chemical formula 1 is now found as a subs...
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WO/2006/099699A1 |
The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in combination with a source of methylated 5...
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WO/2006/098959A1 |
The present invention is concerned with novel processes for the preparation of (R)-4,4-dimethoxy–pyran-3-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity including CCR2...
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WO/2006/098585A1 |
The present invention relates to a method that improves productivity of a useful secondary metabolite by eliminating biological by-products effectively during the culture of a useful secondary metabolite-producing microorganism, and more...
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WO/2006/095444A1 |
A stemphone is produced by culturing cells of Aspergillus sp. FKI-2136 (NITE ABP-83), a microorganism belonging to the genus Aspergillus and capable of producing a stemphone, in a culture medium to accumulate the stemphone in the culture...
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WO/2006/094945A2 |
The invention concerns a method for producing optically active alcohols of formula (I) by means of enzymatic reduction of the corresponding ketones, in particular, the production of (1S)-3-methylamino-1-(2-thienyl)-propane-1-ol and (1S)-...
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WO/2006/094800A2 |
The invention relates to a process, which comprises converting a chemical substrate into a chemical product by a cascade reaction wherein an enzyme-catalysed chemical transformation reaction and a metal-catalysed chemical transformation ...
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WO/2006/093368A1 |
Disclosed is a kaempferol preparing method comprising isolating kaempferol from kaempferol glucosides using an acid, a base, an enzyme or a microbe producing the enzyme. More specifically, the method comprises obtaining a plant extract c...
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WO/2006/091669A1 |
Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-canc...
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WO/2006/084724A1 |
The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the fu...
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