Title:
METHOD FOR PRODUCING CYCLOASTRAGENOL ANALOG
Document Type and Number:
WIPO Patent Application WO/2020/137706
Kind Code:
A1
Abstract:
[Problem] The purpose of the present invention is to provide a new method for producing a cycloastragenol analog from astragaloside IV. {Solution] A method for producing a cycloastragenol analog that includes a contact step that brings astragaloside IV into contact with bacteria.
Inventors:
OGAWA JUN (JP)
KISHINO SHIGENOBU (JP)
FUKAMI HIROYUKI (JP)
HIGA YUUKI (JP)
KISHINO SHIGENOBU (JP)
FUKAMI HIROYUKI (JP)
HIGA YUUKI (JP)
Application Number:
PCT/JP2019/049408
Publication Date:
July 02, 2020
Filing Date:
December 17, 2019
Export Citation:
Assignee:
KOBAYASHI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/58; A61K31/7048; A61P9/00; C07H15/26; C07J17/00; C12P17/04; C12P19/56; C12P33/20
Other References:
JIN, Y ET AL.: "Disposition of Astragaloside IV via Enterohepatic Circulation Is Affected by the Activity of the Intestinal Microbiome", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 63, no. 23, 2015, pages 6084 - 6093, XP055724315, ISSN: 0021-8561
WANG, L ET AL.: "Efficient Biotransformation of Astragaloside IV to Cycloastragenol by Bacillus sp. LG-502", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, vol. 183, no. 4, 2017, pages 1488 - 1502, XP036370345, ISSN: 0273-2289, DOI: 10.1007/s12010-017-2517-1
ITOH, KIKUJI: "Non-official translation: Enteric bacteria and animal experimental system", KAGAKU TO SEIBUTSU, vol. 32, no. 1, 1994, pages 44 - 47, ISSN: 1883-6852
WANG, L ET AL.: "Efficient Biotransformation of Astragaloside IV to Cycloastragenol by Bacillus sp. LG-502", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, vol. 183, no. 4, 2017, pages 1488 - 1502, XP036370345, ISSN: 0273-2289, DOI: 10.1007/s12010-017-2517-1
ITOH, KIKUJI: "Non-official translation: Enteric bacteria and animal experimental system", KAGAKU TO SEIBUTSU, vol. 32, no. 1, 1994, pages 44 - 47, ISSN: 1883-6852
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