Title:
METHOD FOR THE PRODUCTION OF THIOCARBAMATE DERIVATIVES A2AR INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2022/089572
Kind Code:
A1
Abstract:
The present disclosure relates to synthesis of enantiomerically rich key drug intermediates as a means for manufacturing of thiocarbamate derivatives as A2A adenosine receptor (A2AR) inhibitors. More particularly, the present disclosure provides a viable efficient technology using enzymatic biotransformation process which utilizes cheaper substrate for production of high value key intermediates for A2AR inhibitors.
Inventors:
JIAO XUECHENG (CN)
DELIGNY MICHAEL (BE)
CROSIGNANI STEFANO (CH)
JIANG XIANGJUN (CN)
DELIGNY MICHAEL (BE)
CROSIGNANI STEFANO (CH)
JIANG XIANGJUN (CN)
Application Number:
PCT/CN2021/127308
Publication Date:
May 05, 2022
Filing Date:
October 29, 2021
Export Citation:
Assignee:
ITEOS BELGIUM SA (BE)
JIAO XUECHENG (CN)
JIAO XUECHENG (CN)
International Classes:
C12P11/00; C12P17/12; C12P41/00
Domestic Patent References:
| WO2018178338A1 | 2018-10-04 |
Foreign References:
| EP2018058301W | 2018-03-30 |
Other References:
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BONG YONG KOY ET AL: "Baeyer-Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 83, no. 14, 20 July 2018 (2018-07-20), pages 7453 - 7458, XP055895407, ISSN: 0022-3263, DOI: 10.1021/acs.joc.8b00468
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RIEBEL A ET AL: "Expanding the set of rhodococcal Baeyer-Villiger monooxygenases by high-throughput cloning, expression and substrate screening", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 95, no. 6, 5 January 2012 (2012-01-05), pages 1479 - 1489, XP035102884, ISSN: 1432-0614, DOI: 10.1007/S00253-011-3823-0
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
PHILIP J . KOCIENSKI: "Protecting Groups", 1994, GEORG THIEME VERLAG
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY INTERSCIENCE
BONG YONG KOY ET AL: "Baeyer-Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 83, no. 14, 20 July 2018 (2018-07-20), pages 7453 - 7458, XP055895407, ISSN: 0022-3263, DOI: 10.1021/acs.joc.8b00468
WANDA MACZKA ET AL: "Biotechnological Methods of Sulfoxidation: Yesterday, Today, Tomorrow", CATALYSTS, vol. 8, no. 12, 5 December 2018 (2018-12-05), CH, pages 624, XP055682502, ISSN: 2073-4344, DOI: 10.3390/catal8120624
RIEBEL A ET AL: "Expanding the set of rhodococcal Baeyer-Villiger monooxygenases by high-throughput cloning, expression and substrate screening", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 95, no. 6, 5 January 2012 (2012-01-05), pages 1479 - 1489, XP035102884, ISSN: 1432-0614, DOI: 10.1007/S00253-011-3823-0
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
PHILIP J . KOCIENSKI: "Protecting Groups", 1994, GEORG THIEME VERLAG
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY INTERSCIENCE
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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