Title:
NOVEL BIOACTIVE SUBSTANCE EXHIBITING ANTIMALARIAL ACTIVITY, AND USE FOR SAME
Document Type and Number:
WIPO Patent Application WO/2022/186328
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by formula (I), and an antimalarial drug comprising the compound.
Inventors:
OSADA HIROYUKI (JP)
MOTOYAMA TAKAYUKI (JP)
ABDELHAKIM ISLAM ADEL (EG)
FUTAMURA YUSHI (JP)
MOTOYAMA TAKAYUKI (JP)
ABDELHAKIM ISLAM ADEL (EG)
FUTAMURA YUSHI (JP)
Application Number:
PCT/JP2022/009098
Publication Date:
September 09, 2022
Filing Date:
March 03, 2022
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
C07D207/273; A61K31/4015; A61P33/06; C12P17/10
Other References:
KLEIGREWE KARIN, AYDIN FILIZ, HOGREFE KIRSTIN, PIECUCH PATRICK, BERGANDER KLAUS, WÜRTHWEIN ERNST-ULRICH, HUMPF HANS-ULRICH: "Structure Elucidation of New Fusarins Revealing Insights in the Rearrangement Mechanisms of the Fusarium Mycotoxin Fusarin C", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 21, 30 May 2012 (2012-05-30), US , pages 5497 - 5505, XP055964018, ISSN: 0021-8561, DOI: 10.1021/jf3009469
KATO SHO; MOTOYAMA TAKAYUKI; URAMOTO MASAKAZU; NOGAWA TOSHIHIKO; KAMAKURA TAKASHI; OSADA HIROYUKI: "Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP UK, LONDON, vol. 73, no. 7, 5 March 2020 (2020-03-05), London, pages 475 - 479, XP037169349, ISSN: 0021-8820, DOI: 10.1038/s41429-020-0295-4
A. ABDELHAKIM ISLAM, BIN MAHMUD FAUZE, MOTOYAMA TAKAYUKI, FUTAMURA YUSHI, TAKAHASHI SHUNJI, OSADA HIROYUKI: "Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-94", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 85, no. 1, 28 January 2022 (2022-01-28), US , pages 63 - 69, XP055964019, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.1c00677
KATO SHO; MOTOYAMA TAKAYUKI; URAMOTO MASAKAZU; NOGAWA TOSHIHIKO; KAMAKURA TAKASHI; OSADA HIROYUKI: "Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP UK, LONDON, vol. 73, no. 7, 5 March 2020 (2020-03-05), London, pages 475 - 479, XP037169349, ISSN: 0021-8820, DOI: 10.1038/s41429-020-0295-4
A. ABDELHAKIM ISLAM, BIN MAHMUD FAUZE, MOTOYAMA TAKAYUKI, FUTAMURA YUSHI, TAKAHASHI SHUNJI, OSADA HIROYUKI: "Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-94", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 85, no. 1, 28 January 2022 (2022-01-28), US , pages 63 - 69, XP055964019, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.1c00677
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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