Title:
NUCLEIC ACID MODIFIED TO OBTAIN ENHANCED ERGOTHIONEINE PRODUCTIVITY, AND MICROORGANISM HAVING GENETIC MODIFICATION
Document Type and Number:
WIPO Patent Application WO/2023/234307
Kind Code:
A1
Abstract:
The purpose of the present invention is to enhance ergothioneine productivity in ergothioneine production through culturing of an ergothioneine-producing filamentous fungus. In the present invention, a genetic mutation that enhances ergothioneine production in an ergothioneine-producing filamentous fungus is identified. The present invention provides: a nucleic acid that includes a conserved region at positions 433-440 in SEQ ID NO. 1 and that has, in a sequence corresponding to SEQ ID NO. 1, a deletion of a region included in a functional domain corresponding to a functional domain at W404-Q515 in SEQ ID NO. 1; and a filamentous fungus having said nucleic acid.
Inventors:
TAJIMA RYOKO (JP)
ICHIKAWA KEIICHI (JP)
ITO KOTARO (JP)
ICHIKAWA KEIICHI (JP)
ITO KOTARO (JP)
Application Number:
PCT/JP2023/020131
Publication Date:
December 07, 2023
Filing Date:
May 30, 2023
Export Citation:
Assignee:
KIKKOMAN CORP (JP)
International Classes:
C12N15/31; C12N1/15; C12N15/63; C12P13/12; C12P17/10
Domestic Patent References:
| WO2016121285A1 | 2016-08-04 |
Other References:
SHUN TAKUSAGAWA, YASUHARU SATOH, IWAO OHTSU, TOHRU DAIRI: "Ergothioneine production with Aspergillus oryzae", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JP, vol. 83, no. 1, 2 January 2019 (2019-01-02), JP , pages 181 - 184, XP055602960, ISSN: 0916-8451, DOI: 10.1080/09168451.2018.1527210
DATABASE UniProtKB 25 May 2022 (2022-05-25), ANONYMOUS : "Full=Uncharacterized protein {ECO:0000313|EMBL:OOO13079.1}", XP093117073, retrieved from UniProt Database accession no. A0A1S9DVH8
DATABASE UniProtKB 25 May 2022 (2022-05-25), ANONYMOUS : "Full=Uncharacterized protein {ECO:0000313|EMBL:OOO13079.1}", XP093117073, retrieved from UniProt Database accession no. A0A1S9DVH8
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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