Title:
METHOD FOR PRODUCING PYRIDOXAMINE PHOSPHATE
Document Type and Number:
WIPO Patent Application WO/2023/234277
Kind Code:
A1
Abstract:
Provided is a production method for obtaining pyridoxamine phosphate having high coenzyme activity with AST or ALT. For the production of pyridoxamine phosphate, pyridoxal kinase and pyridoxamine are brought into contact in the presence of adenosine triphosphate at a pyridoxamine concentration of 2 mM or more, and reacted until the percentage of pyridoxamine remaining is less than 5%.
Inventors:
OBA TAKASHI (JP)
MATSUKAWA HIROKAZU (JP)
SUNAHARA YOSHIKO (JP)
KAMATA MIHO (JP)
MATSUKAWA HIROKAZU (JP)
SUNAHARA YOSHIKO (JP)
KAMATA MIHO (JP)
Application Number:
PCT/JP2023/019997
Publication Date:
December 07, 2023
Filing Date:
May 30, 2023
Export Citation:
Assignee:
ORIENTAL YEAST CO LTD (JP)
International Classes:
C12N9/12; C12P17/12; C12N15/54; C12Q1/52
Foreign References:
| JPS4425782B1 | 1969-10-30 | |||
| JPS4725068B1 | 1972-07-08 | |||
| JPS4725067B1 | 1972-07-08 |
Other References:
YOSHIO UMEMORI, MAKITO TANAKA, YUSUKE TAKAHASHI, KOICHI ASANUMA, SATOSHI TAKAHASHI: "Performance evaluation of AST and ALT IFCC method compatible reagents using pyridoxamine phosphate", CLINICAL CHEMISTRY, vol. 50, no. 4, 31 October 2021 (2021-10-31), JP , pages 355 - 363, XP009551416, ISSN: 0370-5633
GREGORY JESSE F.: "Activity of Pyridoxamine as a Substrate for Brain Pyridoxal Kinase", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 35, no. 2, 1 August 1980 (1980-08-01), GB , pages 511 - 513, XP093117003, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.1980.tb06297.x
GREGORY JESSE F.: "Activity of Pyridoxamine as a Substrate for Brain Pyridoxal Kinase", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 35, no. 2, 1 August 1980 (1980-08-01), GB , pages 511 - 513, XP093117003, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.1980.tb06297.x
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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