Title:
METHOD FOR PREPARING (R)-TEBUCONAZOLE BY MEANS OF ENZYME CHEMICAL PROCESS
Document Type and Number:
WIPO Patent Application WO/2024/078646
Kind Code:
A1
Abstract:
A method for preparing (R)-tebuconazole by means of an enzyme chemical process, comprising: firstly, by taking the whole cell of recombinant bacterium E. coli/Rpeh expressing an epoxide hydrolase as a catalyst, resolving a racemic tebuconazole epoxy intermediate in a mild reaction system to prepare the (R)-tebuconazole epoxy intermediate, wherein the ee value is 92.7% and the yield is 44.0%; and performing a 1,2,4-triazole mediated ring-opening reaction on the (R)-tebuconazole epoxy intermediate under the catalysis of a solid base to prepare (R)-tebuconazole with a high enantiomer purity (＞99% ee).
Inventors:
HU DIE (CN)
HE YUCAI (CN)
HE YUCAI (CN)
Application Number:
PCT/CN2024/071076
Publication Date:
April 18, 2024
Filing Date:
January 08, 2024
Export Citation:
Assignee:
UNIV CHANGZHOU (CN)
International Classes:
C12P17/02; C07D249/08; C12P41/00; C12R1/19
Foreign References:
| CN117143934A | 2023-12-01 | |||
| CN109355271A | 2019-02-19 | |||
| CN109336848A | 2019-02-15 | |||
| AR038555A1 | 2005-01-19 | |||
| CN103435564A | 2013-12-11 | |||
| CN106699675A | 2017-05-24 | |||
| CN115260110A | 2022-11-01 |
Attorney, Agent or Firm:
CHANGZHOU INNOVATION PATENT AGENCY (CN)
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