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WO/2024/096217A1 |
The present invention relates to a modified microorganism of the genus Corynebacterium producing L-glutamic acid and a method for producing L-glutamic acid using same, more specifically to a novel variant of biotin-protein ligase involve...
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WO/2024/094481A1 |
The present invention concerns a microorganism comprising at least one gene coding for a protein having the function of a L-arginine:glycine amidinotransferase and having an increased activity of a transmembrane exporter protein and to a...
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WO/2024/096219A1 |
The present invention relates to a modified microorganism of the genus Corynebacterium producing L-glutamic acid and a method for producing L-glutamic acid using same, more specifically to a novel variant of pantoate-beta-alanine ligase ...
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WO/2024/094483A1 |
The present invention concerns a microorganism comprising at least one gene coding for a protein having the function of a L-arginine:glycine amidinotransferase and having an increased activity of a rt protein belonging to the Amino Acid-...
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WO/2024/093260A1 |
Provided are a bacterial tryptophan-5-hydroxylase and use thereof. The bacterial tryptophan-5-hydroxylase comprises the amino acid sequence set forth in SEQ ID NO. 1, SEQ ID NO. 3, or SEQ ID NO. 5, or an amino acid sequence having 50% or...
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WO/2024/096218A1 |
The present invention relates to a modified microorganism of the genus Corynebacterium producing L-glutamic acid and a method for producing L-glutamic acid using same, more specifically to a novel variant of nicotinamide mononucleotide t...
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WO/2024/092892A1 |
Provided are an edoxaban intermediate and a preparation method therefor. Specifically, the edoxaban intermediate includes intermediate compounds of formula I and formula II. The preparation method comprises: subjecting a compound of form...
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WO/2024/090884A1 |
The present invention relates to a novel phenylalanine:H+ symporter PheP variant and a method for producing L-aromatic amino acids using same, wherein the protein activity of the phenylalanine:H+ symporter PheP variant changes as at leas...
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WO/2024/090883A1 |
The present invention relates to a pyruvate kinase 2 novel variant and a method for producing an L-aromatic amino acid using same. The pyruvate kinase 2 variant has protein activity that is altered by substitution of one or more amino ac...
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WO/2024/090885A1 |
The present invention relates to a novel variant of the DNA-binding transcriptional regulator MalT and a method for producing an L-aromatic amino acid using same. The variant of the DNA-binding transcriptional regulator MalT has protein ...
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WO/2024/084049A2 |
The present invention relates to a genetically engineered host cell producing a metabolite from 3- phosphoglycerate through a metabolic pathway, comprising one or more genetic modifications preventing or reducing or alleviating a negativ...
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WO/2024/085671A1 |
The present application relates to a mutant ribonuclease activity regulating protein and a method for producing L-valine using same.
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WO/2024/084510A1 |
The present invention relates to a cost-effective process for the synthesis of hyper-production of poly gamma glutamic acid using L-glutamic acid independent approach. Specifically, the present invention relates to the synthesis of poly ...
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WO/2024/084098A1 |
The present invention relates to the use of an enzyme which comprises an amino acid sequence with, at least, a 80% sequence identity to sequence SEQ ID NO: 1, for fumonisin degradation in a sample. Furthermore, the present invention rela...
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WO/2024/080173A1 |
[Problem] To provide a method for producing plant-derived free ceramide easily and efficiently by using a plant-based material. [Solution] This method is for producing plant-derived free ceramide, and comprises: an intrinsic enzyme activ...
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WO/2024/077445A1 |
Provided are a 5'UTR element comprising a nucleotide sequence as shown in SEQ ID NO: 11 and the use thereof in the production of L-arginine. Further provided are a functional expression element containing the 5'UTR element and a promoter...
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WO/2024/078367A1 |
A recombinant organism and a method for producing mycosporine-like amino acids. The method comprises: an organism construction step, comprising: providing an organism of which endogenous genes are knocked out, and integrating an xylose m...
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WO/2024/077428A1 |
Provided is an enzyme with D-amino acid synthesis activity. The enzyme has an amino acid sequence as shown in SEQ ID NO: 10. Compared with an original strain before mutation, the enzyme has a higher catalytic activity for D-amino acid sy...
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WO/2024/061455A1 |
The present invention relates to an enzymatically catalyzed method for producing L-glufosinate or a phosphoester thereof. The method comprises a step in which an activated L-homoserine HA (like acetyl or succinyl L-homoserine) is reacted...
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WO/2024/062163A1 |
The invention intends to lower FOS/TAC ratio of material to be stripped thus enabling higher pH and enhancing stripping conditions of it within an ammonia recovery unit (4) of a biogas plant wherein the biogas plant has at least one ammo...
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WO/2024/061456A1 |
The present invention relates to an enzymatically catalyzed method for producing L-glufosinate or a phosphoester thereof. The method comprises a step in which an activated L-homoserine HA is reacted with a substrate S selected from methy...
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WO/2024/049268A1 |
The present invention relates to a Wickerhammyces ciferrii mutant with improved productivity for tetraacetylphytosphingosine (TAPS), and a method for producing TAPS using same. The Wickerhamomyces ciferrii mutant strain provided by the p...
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WO/2024/048661A1 |
The purpose of the present invention is to develop a method for fermentatively producing L-glutamic acid based on a nitrogen molecule in air using nitrogen-fixing bacteria. A culture method, by which a state in which the nitrogen-fixing ...
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WO/2024/041961A2 |
Described is a process for producing nearly enantiomerically pure (1R,2S)-2,6-dimethyl-1-indanamine, said process being characterized by the reaction of a mixture of the four stereoisomers of 2,6-dimethyl-1-indanamine with an acylating o...
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WO/2024/040885A1 |
The present invention relates to an aminoacyl-tRNA synthase mutant and use thereof. The aminoacyl-tRNA synthase mutant is obtained by means of mutation of an amino acid sequence represented by SEQ ID NO: 19, the mutation at least compris...
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WO/2024/041962A1 |
Described is a process for producing nearly enantiomerically pure (1R,2S)-2,6-dimethyl-1-indanamine, said process being characterized by the reaction of a mixture of the four stereoisomers of 2,6-dimethyl-1-indanamine with an acylating o...
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WO/2024/038903A1 |
There is a problem in the supply of ovothiol A and related substances. The present disclosure provides a method for manufacturing ovothiol A or a related substance. This method for manufacturing ovothiol A or a related substance or a m...
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WO/2024/036508A1 |
Provided are a fusion protease, a fusion expression vector, an engineered bacterium, and a method for producing N-acetylneuraminic acid. The fusion protease comprises N-acetyl-D-glucosamine 2-epimerase (AGE), N-acetylneuraminic acid aldo...
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WO/2024/032012A1 |
Provided are a phenylalanine ammonia lyase mutant, an encoding gene thereof, a genetically engineered microorganism, and a method for preparing the phenylalanine ammonia lyase mutant. Also provided is use of the phenylalanine ammonia lya...
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WO/2024/035140A1 |
The present application relates to a novel acetohydroxy acid synthase subunit (ilvN) variant, a polynucleotide encoding the variant, an L-valine-producing microorganism including the acetohydroxy acid synthase subunit (ilvN) variant of t...
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WO/2024/035191A1 |
The present application relates to: a Ketol-acid reductoisomerase variant; a polynucleotide encoding the variant of the present application; an L-valine-producing microorganism including the ketol-acid reductoisomerase variant or polynuc...
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WO/2024/028361A1 |
The present invention concerns a metabolically engineered microorganism for glycine bioproduction or a salt or an ester thereof, the genome of said microorganism comprises an attenuation of the expression of genes encoding enzymes having...
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WO/2024/028558A1 |
The subject of the present invention is that of preparing glucosylated mycosporines by means of an enzymatic cascade method using α-transglucosylases and sucrose, and use thereof in particular for their anti-UV properties.
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WO/2024/023784A1 |
The present invention relates to a method for increasing production of a lyso-ornithine lipid in a microorganism, by expressing a heterologous ornithine acyl-ACP N-acyltransferase and elevating levels of an acyl carrier protein in the mi...
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WO/2024/026353A2 |
The present invention relates to methods of producing compounds of interest in a recombinant microorganism. In particular, the present invention relates to using a recombinant microorganism comprising a heterologous nucleic acid encoding...
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WO/2024/019215A1 |
The present invention relates to a Corynebacterium sp. microbe with enhanced L-arginine or L-citrulline production capability and a method for producing L-arginine or L-citrulline by using same. The Corynebacterium sp. variant can improv...
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WO/2024/017923A1 |
Herein is reported a polypeptide-linker-nucleic acid conjugate, wherein the linker comprises a 3-amino propanamide unit, a 2,6-diamino hexanoic acid amide unit, and a 1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d]-1
,2,3-tria...
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WO/2024/019216A1 |
The present invention relates to a microorganism of the genus Corynebacterium having an improved ability to produce L-arginine or L-citrulline, and to a method for producing L-arginine or L-citrulline using same. The variant of the genus...
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WO/2024/014697A1 |
The present invention relates to a Corynebacterium sp. microbial variant producing L-glutamic acid and a method for producing L-glutamic acid by using same, and, more particularly, to a novel variant of FAD-dependent oxidoreductase invol...
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WO/2024/014882A1 |
The present invention relates to: a Bacillus coagulans PA strain for producing a large amount of polyamine; and a polyamine preparation method using same. The Bacillus coagulans PA strain of the present invention proliferates in anaerobi...
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WO/2024/014696A1 |
The present invention relates to: an L-glutamic acid-producing mutant microorganism of the genus Corynebacterium; and a method for producing L-glutamic acid using same. More specifically, the present invention relates to: a novel variant...
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WO/2024/011666A1 |
A recombinant Escherichia coli modified by metabolic engineering means and a method for producing L-homoserine by using same. The strain is Escherichia coli having a strain number of 13-XA, and is deposited in China General Microbiologic...
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WO/2024/013258A1 |
The present disclosure describes a method for producing cysteine and/or cystine comprising a) providing a fermentation medium comprising serine from of a genetically engineered host cell producing said serine; b) providing one or more so...
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WO/2024/014699A1 |
The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method for producing L-glutamic acid using same and, more specifically, to a novel mutant redox enzyme involved in the L-glutamic...
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WO/2024/014698A1 |
The present invention relates to a mutant microorganism of the genus Corynebacterium which produces L-glutamic acid and a method for producing L-glutamic acid using same. More specifically, the present invention relates to a novel malate...
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WO/2024/014700A1 |
The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method for producing L-glutamic acid using same and, more specifically, to a novel mutant deoxyribose phosphate aldorase involved...
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WO/2024/010529A1 |
Disclosed herein is a method of producing an enantiomerically pure or enantiomerically enriched alcohol, acid or amine from a racemic 2-alkyl-3-phenyl oxirane or derivative thereof and/or a racemic 2-alkyl-2-phenyl oxirane or derivative ...
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WO/2024/000364A1 |
The present invention relates to the technical field of gene engineering and mutagenesis, and provides a corynebacterium glutamicum (C. glutamicum) efficient mutant, a recombinant bacterium construction method and a use. A highly conserv...
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WO/2024/000368A1 |
The present invention relates to the technical field of genetic engineering, and provides recombinant Escherichia coli and a construction method therefor, and a method for synthesizing 1,5-pentanediamine. The recombinant Escherichia coli...
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WO/2024/004661A1 |
A mutant nitrile hydratase mutated from a nitrile hydratase, said nitrile hydratase being derived from Pseudonocardia thermophila and having an α subunit having 90% or more sequence identity with SEQ ID NO: 1 and a β subunit having 90%...
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