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WO/2023/142860A1 |
The present invention provides a method for constructing a threonine-producing genetically engineered bacterium. According to the present invention, by means of reducing the activity of 2-formyl-citrate synthase 2 or inactivating the syn...
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WO/2023/142859A1 |
The present invention relates to the technical field of microbial engineering, and in particular to a modified Corynebacterium microorganism, a method for constructing same and use thereof. The present invention provides use of weakening...
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WO/2023/142873A1 |
The present invention relates to the technical field of microbial engineering. Specifically disclosed are a modified microorganism of corynebacterium genus, use thereof in producing threonine, and a method for constructing the same. The ...
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WO/2023/142862A1 |
Provided are a recombinant microorganism for producing threonine and the use thereof in the fermentation production of threonine or a derivative thereof. A 20-30 bp fragment upstream of an initiation codon of a gene encoding phosphoenolp...
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WO/2023/142853A1 |
Provided is a method for constructing a genetically engineered bacterium for highly producing threonine. The ability of the strain to produce threonine is improved by means of reducing the activity of the transcriptional regulation facto...
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WO/2023/143621A1 |
Provided are a D-amino acid oxidase and use thereof in the preparation of L-phosphinothricin or an intermediate thereof. Provided is a D-amino acid oxidase having an amino acid sequence comprising an amino acid residue difference as comp...
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WO/2023/136421A1 |
The present invention relates to a mutant in Escherichia having enhanced L-histidine productivity and a method for producing L-histidine using the mutant in Escherichia. The mutant in Escherichia increases or strengthens the expression o...
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WO/2023/136422A1 |
The present invention relates to a mutant in Escherichia having enhanced L-histidine productivity and a method for producing L-histidine using the mutant in Escherichia. The mutant in Escherichia weakens the activity of genes coding for ...
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WO/2023/133484A1 |
Aspects of the disclosure relate to modified skin commensal bacterial host cells capable of producing anthranilate or derivatives thereof.
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WO/2023/132122A1 |
This invention relates to a microorganism (NITE BP-03572) belonging to Rhodosporidiobolus azoricus or a microorganism (NITE BP-03573) belonging to the Vanrija genus.
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WO/2023/123589A1 |
Disclosed are a transaminase mutant and the use thereof, wherein the transaminase mutant has a sequence formed after an amino acid mutation occurs in the sequence shown in SEQ ID NO: 1, wherein the site at which the amino acid mutation o...
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WO/2023/126017A2 |
Disclosed in the present invention are an L-threonine aldolase, and a preparation method therefor and the use thereof. An L-threonine aldolase. The differences between the L-threonine aldolase and SEQ ID NO: 1 lie in that the L-threonine...
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WO/2023/125769A1 |
Modified glutamate dehydrogenase (GluDH) is provided. Specifically, the modified GluDH has increased activity of catalyzing PPO to react with an amino donor and generate L-glufosinate and/or an improved dyanamical property. Further provi...
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WO/2023/125330A1 |
Provided is a type of Saccharomyces cerevisiae, the preservation number thereof being CCTCC NO: M20211621. Further provided is a preparation method for a low-irritation γ-aminobutyric acid product. The preparation method comprises the f...
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WO/2023/124062A1 |
Provided is a method for preparing γ-PGA coupled with an ATP regeneration enzyme and a poly(glutamic acid) synthetase, specifically a method for preparing a poly(glutamic acid) (γ-PGA) using glutamic acid or sodium glutamate as a subst...
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WO/2023/128568A1 |
The present application relates to: a microorganism in which erythronate-4-phosphate dehydrogenase protein activity is weakened; a method for producing O-phosphoserine, cysteine, and a cysteine derivative by using same; an O-phosphoserin...
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WO/2023/127752A1 |
A polypeptide that has a sequence having a sequence identity of 90% or more with respect to a sequence obtained by modifying one amino acid residue in the amino acid sequence represented by SEQ ID NO: 1, and that has a catalytic activity...
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WO/2023/121423A1 |
The present application relates to a method for preparing amino acid granules from a fermented solution, wherein the prepared amino acid granules are free of fungus.
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WO/2023/121055A1 |
The present invention relates to a microorganism capable of producing L-isoleucine, into which a gene encoding an exogenous glutamate dehydrogenate is introduced, an L-isoleucine producing method using the microorganism, and an L-isoleuc...
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WO/2023/117756A1 |
The present invention relates to a process for recovering aminobenzoic acid from an aqueous mother liquor which is produced on crystallization of aminobenzoic acid. The process comprises a step (A) of fermenting a suitable fermentable ra...
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WO/2023/111055A1 |
The present invention relates to the use of special variants of the 3-desoxyarabinoheptulosanate-7-phosphate synthase for preparing ortho-aminobenzoic acid by microbial fermentation and microorganisms which are suitable for this purpose.
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WO/2023/111053A2 |
The present invention relates to the preparation of ortho-aminobenzoic acid by means of microbial fermentation, wherein mixtures of glucose and xylose are used as fermentable substrates.
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WO/2023/106300A1 |
The present disclosure provides a system for culturing animal cells by using, as a source of nutrient, components derived from a living organism such as algae, and for reutilizing a waste culture liquid obtained therefrom. The present ...
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WO/2023/104957A1 |
The invention relates to a method for sequestering carbon or removing carbon dioxide from air using a bioreactor inoculated with autotrophic microorganisms, the carbon dioxide from air being the sole carbon source.
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WO/2023/106543A1 |
The present invention relates to a Corynebacterium glutamicum variant having improved L-lysine production ability and a method for producing L-lysine by using same. The Corynebacterium glutamicum variant can have an improved L-lysine pro...
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WO/2023/102816A1 |
Provided are a fusion gene comprising a PhoD signal peptide and a rocF gene, an expression cassette comprising the fusion gene, and a recombinant expression vector. Also provided are a genetically engineered bacterium and a construction ...
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WO/2023/106620A1 |
The present invention relates to a method for producing tyrosine with high purity from a fermented broth containing tyrosine produced by microbial fermentation, the method comprising the steps of: adding a basic solution and dissolving t...
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WO/2023/102374A1 |
The present invention relates to an aminotransaminase useful in the synthesis of (R)-3-aminobutan-1-ol (RABO). The present invention also provides a process of preparing (R)-3-aminobutan-1-ol (RABO) with the disclosed aminotransaminase.
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WO/2023/098453A1 |
Provided are a nitrile hydratase mutant or a fragment thereof and the use thereof. Compared with wild-type nitrile hydratase, the nitrile hydratase mutant or fragment thereof comprises the following mutations: mutation I, which is a hydr...
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WO/2023/095896A1 |
This genetically modified microorganism satisfies at least one condition selected from the group consisting of conditions (I) and (II). Condition (I): in comparison with a wild-type microorganism corresponding to the genetically modified...
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WO/2023/094011A1 |
The invention relates to a method for preparing L-cysteic acid, in which method O-acetyl-L-serine (OAS) is reacted with at least one enzyme selected from the class of O-acetyl-L-serine-sulfhydrylases (OAS sulfhydrylases, EC 4.2.99.8) in ...
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WO/2023/094010A1 |
The invention relates to a process for producing taurine from O-acetyl-L-serine (OAS) by way of biotransformation. In a first process step (biotransformation 1), L-cysteic acid is produced from O-acetyl-L-serine (OAS) using an enzyme sel...
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WO/2023/090378A1 |
Provided is a method for efficiently producing 3,4-dihydroxyphenylalanine from protocatechuic acid using cultured cells of a microorganism. According to the present invention, a production method for 3,4-dihydroxyphenylalanine includes...
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WO/2023/089028A1 |
The present invention relates to a microorganism genetically modified for improved production of valine, wherein the microorganism overexpresses a ilvA gene coding a threonine deaminase and/or exhibits an increased threonine deaminase ac...
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WO/2023/090821A1 |
The present application relates to a novel Aspergillus oryzae CJI1100 strain and a mycelium produced therefrom. Using the novel Aspergillus oryzae CJI1100 strain of the present application, a mycelium including all the kinds of essential...
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WO/2023/088077A1 |
Provided is an engineered polypeptide capable of catalyzing the asymmetric hydrolysis of 3-isobutylglutarimide to generate (R) - (-) -3- (carbamoylmethyl) -5-methylhexanoic acid. The engineered polypeptide has high stereoselectivity, hig...
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WO/2023/086520A2 |
The present disclosure provides engineered enzymes and methods for preparing tyrosine and tyrosine analogs from a donor amino acid and phenols in a single step. Also disclosed are methods to engineer enzymes having such 'tyrosine synthas...
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WO/2023/079812A1 |
This method for producing an ultrafine-bubble-containing liquid includes a supply step for supplying a liquid L10 that contains at least one substance selected from the group indicated below to a liquid supply region 22 in which is dispo...
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WO/2023/075397A1 |
The present application provides a LysE variant.
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WO/2023/071580A1 |
Provided are a recombinant microorganism constructed based on a lysine efflux protein, a method for constructing the recombinant microorganism, a lysine producing strain, and a method for producing lysine. The polypeptide having the sequ...
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WO/2023/068295A1 |
The present invention relates to a novel bioprocess and bioprocess device in which the CO2 in a gas can be utilized as a substrate. The bioprocess involves (a) causing a CO2-containing gas (G) to contact an alkali, thereby causing the al...
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WO/2023/063547A1 |
The present invention relates to a Corynebacterium glutamicum variant having improved L-lysine production ability and a method for producing L-lysine by using same. The Corynebacterium glutamicum variant is increased or strengthened in t...
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WO/2023/063763A1 |
The present application pertains to: an L-arginine-producing microorganism in which proteins containing the amino acid sequence of SEQ ID NO: 1 are attenuated; and a method for producing L-arginine using same.
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WO/2023/056699A1 |
Disclosed are a genetically engineered strain capable of producing L-alanine, a construction method therefor, and an application thereof. A genetically engineered strain capable of efficiently producing alanine at a high temperature of 4...
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WO/2023/056700A1 |
A genetically engineered bacterial strain producing DL-alanine, a construction method therefor and an application thereof, which relate to the field of bioengineering. By enhancing a glycolytic pathway and introducing a thermostable alan...
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WO/2023/054882A1 |
The present application relates to a novel acetohydroxy acid synthase (AHAS) mutant with enhanced L-isoleucine productivity, a microorganism including same, and a method for producing L-isoleucine, using the microorganism and aims to fin...
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WO/2023/050516A1 |
Provided are a transaminase mutant and an application thereof. The transaminase mutant has an amino acid mutation based on a sequence shown in SEQ ID NO: 1, the amino acid mutation being a single position mutation from among W60Y, Y168A,...
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WO/2023/054881A1 |
The present application relates to a novel acetohydroxy acid synthase (AHAS) variant that improves L-isoleucine production ability, a microorganism containing same, and a method for producing L-isoleucine using the microorganism. The pur...
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WO/2023/048480A1 |
The present application relates to a strain and a microorganism for producing high concentration L-glutamic acid and a method of use thereof.
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WO/2023/042081A1 |
The invention relates to a process to produce a (1r,4r)-4-substituted cyclohexane-1-amine [further referred as trans-4-substituted cyclohexane-1-amine] of formula (T), starting from a diastereomeric mixture of 4-substituted cyclohexane-1...
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