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WO/2023/197968A1 |
The present invention relates to the technical field of genetic engineering and fermentation engineering, and particularly, to a method for preparing isopropanolamine. The method is characterized in that threonine is converted into L-2-a...
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WO/2023/196890A1 |
The present invention provides modified sophorolipids modified with amino acids to improve, e.g., the bioavailability of the amino acids. The modified sophorolipids of the present invention are capable of efficiently delivering the amino...
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WO/2023/197017A1 |
A method for preparing chiral amines useful as pharmaceutical intermediates is provided. The method comprises contacting an ester of formula I in which R1 is a methyl or an ethyl group; R2 is a linear or branched C1 – C4 alkyl group; a...
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WO/2023/196276A1 |
A method to prepare ɤ-L-Glutamyl-L-Cysteine or bis- ɤ-L-Glutamyl-L-Cystine including direct reaction of cysteine or cystine with Di-tert-butyl (S)-(2,6-dioxotetrahydro-2H-pyran-3-yl)iminodicarbonate (formula 5) is provided (I).
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WO/2023/194440A1 |
The invention relates to novel urethanases for the enzymatic degradation of polyurethanes and to an enzymatic process for the complete degradation of polyurethanes in defined monomers.
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WO/2023/186037A1 |
Provided is a method for preparing glycine by using threonine. In a fermentation process, threonine is decomposed into glycine and acetaldehyde by aldolase. Also provided is a method for simultaneously preparing glycine and acetyl coenzy...
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WO/2023/184791A1 |
Disclosed is a method for enzymatic synthesis of a brivaracetam chiral intermediate, i.e., a method for synthesizing a brivaracetam chiral intermediate (R)-3-cyanohexanoic acid by catalyzing the hydrolysis of 3-cyanohexanitrile using an ...
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WO/2023/191263A1 |
The present application relates to: a microorganism with attenuated SIRT-type deacetylase protein activity; a method for producing O-acetyl homoserine and L-methionine using same; a composition for producing O-acetyl homoserine comprisin...
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WO/2023/191264A1 |
The present application relates to: a microorganism with attenuated GNAT family N-acetyltransferase protein activity; a method for producing O-acetyl homoserine and L-methionine using same; a composition for producing O-acetyl homoserine...
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WO/2023/158403A9 |
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WO/2023/158174A9 |
The present invention relates to a sigma 38 novel variant and a method for producing an L-aromatic amino acid using same. The sigma 38 variant has protein activity that is altered by substituting one or more amino acids in an amino acid ...
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WO/2023/178849A1 |
The present invention relates to the field of biotechnology. Provided is an Escherichia coli strain for synthesizing L-valine, a method for constructing same, and use thereof. Provided is an Escherichia coli strain named as Escherichia c...
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WO/2023/183785A2 |
The present invention relates to a variant nitrile hydratase which is engineered to comprise greater activity and/or stability, nucleic acids encoding said nitrile hydratase, and microbia engineered to express said novel nitrile hydratas...
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WO/2023/158176A9 |
The present invention relates to: a novel stress protein variant; and a method for producing L-aromatic amino acid using same. The stress protein variant has modified protein activity due to the substitution of one or more amino acids in...
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WO/2023/177842A1 |
Described herein is a process for performing amidation of polyolefins including reacting a polyolefin, a copper catalyst, an amide, a ligand and an oxidant. Specifically, polyethylene may be reacting to have a degree of amide incorporati...
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WO/2023/177253A1 |
The present application provides: a variant polypeptide having an activity of aspartate 1-dicarboxylase; a microorganism including same; a composition for producing beta-alanine or beta-alanine-derived compounds, the composition comprisi...
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WO/2023/177254A1 |
The present application provides: a microorganism with enhanced activity of aspartate 1-decarboxylase derived from Tribolium castaneum; a composition for producing beta-alanine and/or a beta-alanine-derived compound, the composition comp...
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WO/2023/158175A9 |
The present invention relates to a novel transport protein variant and a method for producing an L-aromatic amino acid using same. The transport protein variant has changed protein activity through substitution of at least one amino acid...
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WO/2023/176487A1 |
The production method according to the present invention is characterized in that a D-amino acid oxidase used in step 2 in the scheme shown below is a polypeptide selected from the below-mentioned polypeptides (a) to (c). According to th...
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WO/2023/177160A1 |
The present application relates to an L-amino acid-producing microorganism having weakened carbamoyl phosphate synthase activity, and an L-amino acid production method using same.
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WO/2023/174511A1 |
The present invention relates in a first aspect to an enzymatic method for the production of an L-glufosinate P-ester. This method is characterized by a step (c) in which an L-glufosinate P-ester carbamoylate is reacted to give the corre...
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WO/2023/178318A2 |
The invention provides a method for producing in vitro a beta-hydroxy non- standard amino acid (0-OH-nsAA). The in vitro method comprises incubating L- threonine, an aldehyde and an L-threonine transaldolase (TTA). Also provided is a met...
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WO/2023/177161A1 |
The present application relates to a carbamoyl-phosphate synthetase large subunit variant, a polynucleotide for coding the variant, a microorganism comprising the variant or the polynucleotide, and an L-ornithine production method using ...
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WO/2023/142861A9 |
The present invention provides a method for constructing a threonine-producing engineered bacterium. According to the present invention, a 2-formyl-citrate synthase 1-inactivated strain (corynebacterium) is applied to the production of t...
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WO/2023/171996A1 |
The present application relates to a variant L-threonine export protein and a method for producing L-threonine using same.
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WO/2023/169168A1 |
The present invention relates to the field of microorganisms, in particular to a method for producing vitamin B5 by means of high-activity aspartate decarboxylase. L-aspartate α-decarboxylase (PanD) derived from Bacillus licheniformis i...
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WO/2023/171997A1 |
The present application relates to a mutant L-threonine-releasing protein and a method for producing L-threonine using same.
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WO/2023/169176A1 |
Escherichia coli for expressing aspartate dehydrogenase gene (aspDH) and a method for using same for fermentation production of vitamin B5 (VB5). By comparing the fermentation yield of VB5, it is found that overexpressing the aspDH gene ...
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WO/2023/167563A1 |
The present invention relates to a method for biosynthesizing N-carbamyl-L-glutamic acid and a novel use thereof for the prevention or treatment of inflammatory diseases. The invention also relates to a composition for the prevention, am...
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WO/2023/165684A1 |
The invention relates to a microorganism strain with a deregulated cysteine biosynthetic pathway, said strain thus being suitable for the fermentative production of at least one substance selected from L-cysteine, L-cystine, and thiazoli...
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WO/2023/167314A1 |
This method for hydrolyzing nylon involves monomerizing nylon using nylon hydrolase, and comprises: a step for dissolving nylon in an organic solvent in which nylon is soluble so as to prepare a nylon solution; a step for preparing a nyl...
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WO/2023/161296A1 |
Described herein are methods for conjugating moieties of interest, such as pharmaceutically active molecules, to targeting molecules such as antibodies using transglutaminase-based processes.
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WO/2023/159794A1 |
Provided is a 2,4-diaminopyrimidine oxide preparation method. The preparation method comprises the following steps: carrying out a cyclization reaction on 3-oxopropionitrile and guanidine under an oxidation condition to produce 2,4-diami...
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WO/2023/158030A1 |
The present invention relates to a novel zinc-binding dehydrogenase variant and a method for producing L-aromatic amino acid using same. The zinc-binding dehydrogenase variant has modified enzyme activity due to the substitution of one o...
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WO/2023/158029A1 |
The present invention relates to a novel ATP synthase variant and a method for producing L-aromatic amino acid using same. The ATP synthase variant has modified enzyme activity due to the substitution of one or more amino acids in the am...
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WO/2023/158722A2 |
The present disclosure encompasses a process for chiral resolution of racemic amines, particularly ethyl 2-(4-((tert-butoxycarbonyl)amino)phenyl)piperidine-3-carboxy
late, into its desired isomer, ethyl (2R,3S)-2-(4-((tert-butoxycarbonyl...
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WO/2023/151407A1 |
Provided in the present invention is a construction method for a threonine-producing strain. The present invention performs superimposed modification on a plurality of enzymes related to threonine synthesis and redox capacity supplement,...
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WO/2023/151412A1 |
Provided are a modified Corynebacterium microorganism, a construction method therefor, and a use thereof in production of threonine. The modified Corynebacterium microorganism provided is a Corynebacterium having inactive or activity-red...
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WO/2023/151411A1 |
The present invention relates to the technical field of microbial engineering, in particular to a recombinant microorganism for producing threonine, and a construction method therefor and the use thereof. In the present invention, an ace...
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WO/2023/151406A1 |
Provided in the present invention is a method for constructing a threonine-producing strain. By means of performing overlay modification on a plurality of enzymes related to the synthesis of threonine, including aspartate aminotransferas...
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WO/2023/151409A1 |
The present invention provides a method for constructing high-yield engineered bacteria for threonine. According to the present invention, strains of which the activities of aspartate aminotransferase, aspartokinase, homoserine dehydroge...
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WO/2023/151421A1 |
Provided are a modified Corynebacterium microorganism, a construction method therefor, and the use thereof in the production of threonine. The modified Corynebacterium microorganism has a weakened or inactivated expression of Cgl0978 gen...
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WO/2023/151408A1 |
Provided in the present invention is a construction method for a strain with high-yield production of threonine. In the present invention, the expression of one or more of aspartate aminotransferase, aspartokinase and threonine synthase ...
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WO/2023/149514A1 |
The present invention relates to a method for producing a dicarboxylic acid compound and/or a diamine compound and optionally a dehydration-condensation product of a dicarboxylic acid compound and a diamine compound (i.e., a dehydration-...
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WO/2023/142855A1 |
The present invention relates to the technical field of microbial engineering. Specifically disclosed are a recombinant microorganism, a method for constructing same and use thereof. According to the present invention, by means of constr...
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WO/2023/142872A1 |
The present invention relates to the technical field of microbial engineering. Specifically disclosed are a modified microorganism of corynebacterium genus producing threonine, a method for constructing the same, and use thereof. The act...
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WO/2023/142854A1 |
Provided is a method for constructing a threonine production strain. By means of constructing a corynebacterium having an enhanced transketolase activity, the threonine production capacity of the strain is improved. In combination with e...
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WO/2023/142871A1 |
The present invention relates to the technical field of microbial engineering. Specifically disclosed are a modified microorganism of the corynebacterium genus, a method for constructing same and use thereof. The activity of oxaloacetate...
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WO/2023/142848A1 |
Provided is a promoter, which has a nucleotide sequence shown in SEQ ID NO.1. The promoter is obtained by means of rationally designing a promoter of a dapA gene, has obviously reduced transcriptional activity and can be used for the wea...
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WO/2023/142178A1 |
Provided is a glutamic acid decarboxylase (GAD) mutant with improved pH tolerance and use thereof in gamma-aminobutyric acid synthesis. The mutant is obtained by mutating an amino acid sequence, such as the GAD set forth in SEQ ID NO. 3....
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