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WO/2019/238725A1 |
The present invention relates to a method for preparing a methionine analogue, comprising contacting a host cell with L-homoserine and one or more nucleophiles and cultivating said host cell and said one or more nucleophiles of (a) in a ...
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WO/2019/240243A1 |
The purpose of the present invention is to provide a selenoneine production method with which selenoneine can be produced at high yields even if an inorganic selenium compound is used as the selenium compound. This purpose is achieved by...
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WO/2019/241132A1 |
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity and enhanced ac...
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WO/2019/234092A1 |
The invention relates to a method for producing aminobenzoic acid or an aminobenzoic acid derivative using a fermentation process, in which (I) the aminobenzoic acid formed in the fermentation broth obtained by the fermentation is bound ...
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WO/2019/231159A1 |
The present application pertains to a modified homoserine dehydrogenase, and a method for producing a homoserine or a homoserine-derived L-amino acid using same.
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WO/2019/225475A1 |
The present invention provides a fermentation process capable of increasing the quantity of target substances due to microorganisms by efficiently switching over a fungus body growth phase and a substance production phase without using a...
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WO/2019/214084A1 |
Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catal...
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WO/2019/211958A1 |
Provided is a method for improving the efficiency of production of an organic compound by a bacterium that does not inherently have an endogenous ED pathway. One embodiment pertains to a transformant of a coryneform bacterium obtained by...
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WO/2019/211127A1 |
The present invention relates to a polyurea coating composition comprising (A) a polyisocyanate; (B) a polyaspartic ester; and (C) an aspartic ester. The polyaspartic ester (B) is represented by the structure (I), where Z = a cycloalkyl,...
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WO/2019/213108A1 |
Provided herein are methods for increasing the yield of an extracellular product synthesized by an organism cultured in a continuous aerobic fermentation system. The extracellular product yield is increased through the use of an organism...
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WO/2019/213028A1 |
Methods for increasing carbon-based chemical product yield in an organism by genetically modifying one or more genes involved in a stringent response and/or in a regulatory network, nonnaturally occurring organisms having increased carbo...
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WO/2019/211408A1 |
Provided is a method of modulating the trimethylamine (TMA) levels, odour and/or taste of an aquatic biological material, the method comprising contacting the aquatic biological material with a trimethylamine oxidase. Also provided are n...
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WO/2019/213019A1 |
Methods for increasing carbon-based chemical product yield in an organism by increasing carbon uptake and/or altering a pathway to or from an overflow metabolite in the organism, nonnaturally occurring organisms having increased carbon-b...
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WO/2019/213033A1 |
Methods of redirecting carbon flux and increasing C2/C3 or a C4/5/6 carbon chain length carbon-based chemical product yield in an organism, nonnaturally occurring organisms with redirected carbon flux and increased C2/C3 or C4/5/6 carbon...
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WO/2019/212052A1 |
The present invention provides a method for producing L-methionine by fermentation using a bacterium belonging to the genus Pantoea which has been modified to overexpress the rarD gene or a mutant gene thereof.
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WO/2019/213017A1 |
Methods for increasing carbon-based chemical product yield in an organism by perturbing redox balance in an organism as well as nonnaturally occurring organisms with perturbed redox balance and methods for their use in producing carbon-b...
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WO/2019/207812A1 |
This transformant obtained by introducing, to hydrogenophilus genus bacteria, DNA of (a1), (a2) or (a3), and (b) a gene of alcohol dehydrogenase, can efficiently produce isobutanol using carbon dioxide as the only source of carbon. DNA (...
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WO/2019/200874A1 |
Provided are a recombinant E. coli and the use thereof in the production of danshensu. The recombinant E. coli simultaneously expresses α-hydroxycarboxylic acid dehydrogenase, L-α-amino acid aminotransferase, and any one of glucose deh...
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WO/2019/198872A1 |
The present invention relates to a method for preparing an amino acid by decomposing protein components in a muscle part of a squid into amino acid components by using activation of a biotic enzyme of the squid caused by adding vitamin C.
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WO/2019/196262A1 |
The present invention relates to the field of pharmaceutical synthesis, and in particularly relates to a preparation method for a hexahydrofuro-furan-ol derivative, and an intermediate of the derivative and a preparation method therefor....
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WO/2019/198367A1 |
This invention provides a method for efficiently producing an N-acyl-amino group-containing compound using an enzymatic method. Specifically, this invention provides a method for producing an N-acyl-amino group-containing compound, inclu...
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WO/2019/192438A1 |
Provided herein are engineered decarboxylase polypeptides that are useful for catalyzing the decarboxylation of amino aicds such as L-tyrosine to produce tyramine or catalyzing the decarboxylation of L-DOPA to produce dopamine. Also prov...
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WO/2019/193607A1 |
The present invention relates to an improved process for the preparation of 3-isobutyl glutaric acid compound of formula-1 which is used as the key intermediate in the preparation of Pregabalin compound of formula-A. The present inventio...
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WO/2019/184936A1 |
Disclosed in the present invention is a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid and a derivative thereof. The method comprises: by using racemic 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (1) or ra...
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WO/2019/191772A1 |
This disclosure relates to strategies for in vivo production of certain carbon-based products, for example, aminated aliphatic compounds having a carbon chain length of C5-C19. Specifically, 7-aminoheptanoic acid is produced using a tran...
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WO/2019/185877A1 |
The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diast...
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WO/2019/190192A1 |
The present application relates to a novel promoter, and a method for producing L-amino acid by using same and, more specifically, to: a novel polynucleotide having a promoter activity, a vector and a Corynebacterium sp. microorganism co...
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WO/2019/190193A1 |
The present application pertains to a microorganism having enhanced glycine productivity and a method for producing a fermented composition by using same and, more particularly, to a Corynebacterium sp. microorganism that has a mutation ...
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WO/2019/189277A1 |
A method for producing an amide compound, said method comprising a step for contacting optionally treated microbial cells containing nitrile hydratase with a nitrile compound in an aqueous medium in a first reactor to give a liquid react...
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WO/2019/183358A2 |
The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. The disclosure is based, in part, on whole cell systems expressing artificial fusion proteins comprising cytochrom...
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WO/2019/182413A1 |
The present application relates to granules containing L-amino acid and a method for preparing same.
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WO/2019/169849A1 |
Provided are a glutamate dehydrogenase mutant and use thereof in preparing L-glufosinate. The amino acid sequence of said mutant, which is as shown in SEQ ID NOs: 1-9, 11, 13, 15, 17-19, or 22, is obtained by means of a molecular modific...
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WO/2019/169467A1 |
The present invention relates to Escherichia coli strains optimized for use of glucose, glycerol, xylose and arabinose as carbon sources for the production of L-lysine, as well as the upregulation and downregulation/deletion of certain g...
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WO/2019/172825A1 |
The present invention relates to a method of separating amino acids from an aqueous solution comprising amino acids as well as proteins and/or protein decomposition products by combining phosphoric acid with the aqueous solution to preci...
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WO/2019/170705A1 |
This invention relates to a compound according to general formula (IA), which acts as a selective cysteine protease inhibitor; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination p...
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WO/2019/172702A1 |
The present application relates to a novel promoter and an L-amino acid production method using same and, more specifically, to a novel polynucleotide having promoter activity, a vector and a Corynebacterium sp. microorganism comprising ...
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WO/2019/168203A1 |
Provided is a novel method for producing 4-aminocinnamic acid from 4-nitrophenylalanine. This method comprises: (1) converting 4-nitrophenylalanine into 4-nitrocinnamic acid; and (2) converting 4-nitrocinnamic acid into 4-aminocinnamic a...
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WO/2019/165551A1 |
Disclosed are methods for converting a substrate into a product alkaloid, including a benzylisoquinoline compound or benzylisoquinoline precursor compound, in a biosynthetic system involving the growth of host cells. The cells comprise a...
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WO/2019/164348A1 |
The present application relates to a microorganism producing L-tryptophan, which is modified to express a novel protein having tryptophan export activity, and a method for producing L-tryptophan using the microorganism.
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WO/2019/163767A1 |
Provided are a method for producing ergothioneine in high yield at low cost and a bacterium for use in the method. This method is designed to produce ergothioneine, a related substance thereof, or a mixture of these, and is characterized...
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WO/2019/164351A1 |
The present application pertains to a mycosporine-like amino acid-producing microorganism and a method for production of mycosporine-like amino acids by using the microorganism. Having an improved mycosporine-like amino acid-producing po...
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WO/2019/164346A1 |
The present application relates to a Corynebacterium sp. microorganism for producing L-tryptophan by using a gene manipulation technique and a method for producing L-tryptophan by using the microorganism.
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WO/2019/160301A1 |
The present application relates to a modified polypeptide with attenuated activity of citrate synthase and a method for producing aspartate-derived L-amino acids using same.
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WO/2019/157921A1 |
Disclosed is a nitrilase mutant and an application thereof. The mutant is obtained by one or more substitutions of amino acids at position 201 or amino acid sequences at positions 324-381 of the amino acid sequence shown in SEQ ID No. 2....
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WO/2019/160705A1 |
The invention provides a process for the preparation of a modified triethanolamine/fatty acid ester composition ratio by treatment of a conventional tnethanolamine fatty acid ester composition with a hydrolytic enzyme. Also provided are ...
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WO/2019/160059A1 |
Provided is a method for recycling s-adenosylmethionine that is characterized in that after s-adenosylmethionine is demethylated, s-adenosylmethionine is regenerated by converting s-adenosylmethionine from methionine obtained by transfer...
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WO/2019/154670A1 |
The present invention relates to recombinant Corynebacterium spp. host cells comprising, in relation to wild-type cells, at least one mutation selected from the group consisting of mutations that (i) reduce the activity of a protein, sel...
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WO/2019/151769A1 |
The present disclosure relates to a method for preparing L-cysteine hydrochloride hydrate crystals, and L-cysteine hydrochloride hydrate crystals prepared by the method. Through the method for preparing L-cysteine hydrochloride hydrate c...
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WO/2019/151770A1 |
The present disclosure relates to a method for preparing L-cysteine crystals, and L-cysteine crystals prepared by the method. Through the method for preparing L-cysteine crystals of the present disclosure, L-cysteine crystals can be obta...
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WO/2019/147059A1 |
The present application relates to a microorganism of the genus Corynebacterium for producing an L-amino acid and a method for producing an L-amino acid by using the microorganism.
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