Title:
PYRUVATE KINASE 2 NOVEL VARIANT AND METHOD FOR PRODUCING L-AROMATIC AMINO ACID USING SAME
Document Type and Number:
WIPO Patent Application WO/2024/090883
Kind Code:
A1
Abstract:
The present invention relates to a pyruvate kinase 2 novel variant and a method for producing an L-aromatic amino acid using same. The pyruvate kinase 2 variant has protein activity that is altered by substitution of one or more amino acids in an amino acid sequence constituting pyruvate kinase 2, and thus a recombinant microorganism comprising the pyruvate kinase 2 variant can efficiently produce an L-tryptophan, an L-phenylalanine, or an L-tyrosine.
Inventors:
KIM HYUN YOUNG (KR)
CHA JOY (KR)
JO YOUNG IL (KR)
CHA JOY (KR)
JO YOUNG IL (KR)
Application Number:
PCT/KR2023/016159
Publication Date:
May 02, 2024
Filing Date:
October 18, 2023
Export Citation:
Assignee:
DAESANG CORP (KR)
International Classes:
C12N9/12; C07K14/245; C12N9/88; C12N9/90; C12N15/52; C12N15/70; C12N15/77; C12P13/22
Foreign References:
| JP2015508647A | 2015-03-23 | |||
| JP2016220680A | 2016-12-28 | |||
| JP2022526181A | 2022-05-23 |
Other References:
DATABASE Protein 3 October 2022 (2022-10-03), ANONYMOUS: "pyruvate kinase [Escherichia coli]", XP093164958, retrieved from NCBI Database accession no. WP_262017857.1
LIHONG DU: "Central metabolic pathway modification to improve L-tryptophan production in Escherichia coli", BIOENGINEERED, LANDES BIOSCIENCE, US, vol. 10, no. 1, 1 January 2019 (2019-01-01), US , pages 59 - 70, XP093164954, ISSN: 2165-5979, DOI: 10.1080/21655979.2019.1592417
LIHONG DU: "Central metabolic pathway modification to improve L-tryptophan production in Escherichia coli", BIOENGINEERED, LANDES BIOSCIENCE, US, vol. 10, no. 1, 1 January 2019 (2019-01-01), US , pages 59 - 70, XP093164954, ISSN: 2165-5979, DOI: 10.1080/21655979.2019.1592417
Attorney, Agent or Firm:
PARK, Hyuk (KR)
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