Title:
NOVEL VARIANT OF DNA-BINDING TRANSCRIPTIONAL REGULATOR MALT AND METHOD FOR PRODUCING L-AROMATIC AMINO ACID USING SAME
Document Type and Number:
WIPO Patent Application WO/2024/090885
Kind Code:
A1
Abstract:
The present invention relates to a novel variant of the DNA-binding transcriptional regulator MalT and a method for producing an L-aromatic amino acid using same. The variant of the DNA-binding transcriptional regulator MalT has protein activity that is altered by substituting one or more amino acids in an amino acid sequence constituting the DNA-binding transcriptional regulator MalT, and thus can efficiently produce L-tryptophan, L-phenylalanine, or L-tyrosine from a recombinant microorganism comprising the variant.
Inventors:
KIM HYUN YOUNG (KR)
CHA JOY (KR)
JO YOUNG IL (KR)
CHA JOY (KR)
JO YOUNG IL (KR)
Application Number:
PCT/KR2023/016162
Publication Date:
May 02, 2024
Filing Date:
October 18, 2023
Export Citation:
Assignee:
DAESANG CORP (KR)
International Classes:
C07K14/245; C12N9/00; C12N15/52; C12N15/70; C12N15/77; C12P13/22
Domestic Patent References:
| WO2020204427A1 | 2020-10-08 |
Foreign References:
| KR20060127990A | 2006-12-13 | |||
| KR102421920B1 | 2022-07-21 |
Other References:
DATABASE Protein 16 April 2020 (2020-04-16), ANONYMOUS: "HTH-type transcriptional regulator MalT [Escherichia coli]", XP093161886, retrieved from NCBI Database accession no. EFD9633396.1
DATABASE Protein 27 February 2021 (2021-02-27), ANONYMOUS: "TPA: HTH-type transcriptional regulator MalT [Escherichia coli]", XP093161891, retrieved from NCBI Database accession no. HAX6690303.1
DATABASE Protein 27 February 2021 (2021-02-27), ANONYMOUS: "TPA: HTH-type transcriptional regulator MalT [Escherichia coli]", XP093161891, retrieved from NCBI Database accession no. HAX6690303.1
Attorney, Agent or Firm:
PARK, Hyuk (KR)
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