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Title:
MICROORGANISM OF GENUS CORYNEBACTERIUM HAVING IMPROVED ABILITY TO PRODUCE L-ARGININE OR L-CITRULLINE, AND METHOD FOR PRODUCING L-ARGININE OR L-CITRULLINE USING SAME
Document Type and Number:
WIPO Patent Application WO/2024/019216
Kind Code:
A1
Abstract:
The present invention relates to a microorganism of the genus Corynebacterium having an improved ability to produce L-arginine or L-citrulline, and to a method for producing L-arginine or L-citrulline using same. The variant of the genus Corynebacterium enhances the activity of an acetylglutamate kinase involved in the L-arginine biosynthesis pathway, and thus can have an improved production yield in terms of the ability to produce L-arginine or L-citrulline compared to a parent strain.

Inventors:
RYU MI (KR)
YOON SUN JUN (KR)
HONG IN PYO (KR)
PARK SEOK HYUN (KR)
Application Number:
PCT/KR2022/012256
Publication Date:
January 25, 2024
Filing Date:
August 17, 2022
Export Citation:
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Assignee:
DAESANG CORP (KR)
International Classes:
C12N15/77; C12N1/20; C12N9/12; C12P13/10
Foreign References:
KR20200081230A2020-07-07
KR100830289B12008-05-16
KR20080006799A2008-01-17
Other References:
MASATO IKEDA, SATOSHI MITSUHASHI, KENJI TANAKA, AND MIKIRO HAYASHI: "Reengineering of a Corynebacterium glutamicum L-arginine and L-citrulline producer", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 75, no. 6, 1 March 2009 (2009-03-01), US , pages 1631 - 1641, XP008160501, ISSN: 0099-2240, DOI: 10.1128/AEM.02027-08
DATABASE Protein 25 May 2022 (2022-05-25), ANONYMOUS: "RecName: Full=Acetylglutamate kinase; AltName: Full=N-acetyl-L-glutamate 5-phosphotransferase; AltName: Full=NAG kinase; Short=NAGK", XP093130653, retrieved from NCBI. Database accession no. Q59281.1
Attorney, Agent or Firm:
PARK, Hyuk (KR)
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