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JP5821132B2 |
The present invention relates to eukaryotic cells which have the ability to isomerise xylose directly into xylulose. The cells have acquired this ability by transformation with nucleotide sequences coding for a xylose isomerase that has ...
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JP5796925B2 |
The present invention relates to genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers on the host cell the ability to isomerize xylose to xylulose. These genetic modificatio...
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JP5762702B2 |
The uses is claimed of: (i) aerogels (AG) for adsorption from a liquid phase; (ii) hydrophilic or hydrophobic AG as adsorbents; and (iii) adsorbents containing AG (not as a mixture with activated carbon or active alumina) for adsorption ...
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JP2015070856A |
To provide a yeast capable of conducting alcoholic fermentation and using xylose as a carbon source.The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable fr...
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JP2014087365A |
To provide a method of applying a chemically defined formulation in industrial scale fermentation, in order to avoid problems associated with a usual use method of a composite culture medium in the current industrial site.Use of a chemic...
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JP5261709B2 |
To provide a method for adding a fatty acid to an amino acid, a peptide and a protein by an enzymatic means, in an aqueous solution. This method for producing a fatty acid-added amino acid or fatty acid-added amino acid derivative, fatty...
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JP2013055948A |
To provide eukaryotic host cells, such as fungal host cells, that are transformed with an XI gene that confers the ability to grow on xylose and which host cells have specific rates of xylose consumption and/or product (ethanol) formatio...
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JP5113800B2 |
The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the ho...
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JP5022913B2 |
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D-phenylglycine in activated form (PGa) in the presence of an enzyme in a reac...
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JP4659111B2 |
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JP4598333B2 |
The present invention relates to a process for delaying the deactivation of glutaryl amidase during enzyme catalysis. The enzyme catalyst is, after maximum conversion of the substrate, separated off by filtration and can be reused in a s...
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JP4469401B2 |
The present invention describes the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemic...
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JP2010516800A |
The invention relates to novel antimicrobial agents that are based on β-lactam derivatives and are produced by reacting previously known β-lactam derivatives with polyphenol oxidase substrates under the influence of free radicals and b...
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JP4334352B2 |
The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the ho...
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JP2009195254A |
To apply a chemically defined treatment in an industrial scale fermentation in order to avoid problems associated with usual methods of using complex media in the present industrial scenes.The use of chemically defined media for fermenta...
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JP4217277B2 |
The present invention describes the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemic...
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JP4147319B2 |
New mutant beta -lactam Penicillin G acylases are provided, exhibiting altered substrate specificities. These Penicillin G acylases are obtained by expression of a gene encoding said Penicillin G acylase and having an amino acid sequence...
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JP4080542B2 |
New mutant penicillin G acylases preferably from E. coli are provided, exhibiting altered enzymatic activity. These penicillin G acylases are obtained by expression of a gene encoding said penicillin G acylase having an amino acid sequen...
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JPWO2005075652A1 |
A modified peptide (ie, modified) with enhanced glutaryl-7-aminocephalosporanic acid (GL-7-ACA) acylase activity using γ-glutamyl transpeptidase (GGT), an enzyme widely distributed in the biological world. It is an object of the present...
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JP3889438B2 |
The present invention relates to an enzyme process for the one-step conversion of cephalosporin C or a derivative thereof into 7-aminocephalosporanic acid or a corresponding derivative thereof. The one step conversion is effected using a...
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JP2007502108A |
A CPC acylase mutant of the present invention has an improved reactivity and specific activity to CPC, which can be efficiently employed for directly preparing 7-ACA from CPC by a one-step enzymatic method.
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JP3856807B2 |
To provide a beta-lactamase as a reporter gene, a beta-lactamase substrate compound and uses thereof for particularly monitoring expression from a pair of expression control sequences to screen a biochemical activity. Disclosed is a reco...
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JP2006514542A |
The present invention relates to isolated nucleic acid molecules which code for a new protein from Acremonium chrysogenum, to vectors which comprise such a nucleic acid molecule, to Acremonium chrysogenum host cells which have been trans...
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JP2006500957A |
The invention relates to a process for the preparation of cephalexin with the aid of a penicillin amidase immobilized on a crosslinked hydrophilic copolymer which has binding activity for ligands having nucleophilic groups and is in bead...
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JP2005348743A |
To provide a catalytic process for enzymatically producing 7-aminocephalosporanic acid (7-ACA) in the absence of esterase activity.Disclosed is a process for decreasing esterase activity present in the presence of D-amino acid oxidase ac...
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JP2005536225A |
The present invention discloses a bioreactor apparatus with an expandable surface area which is useful for culturing cells. A method for culturing cells is also included in the invention. The method comprises providing a container and a ...
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JP2005525102A |
This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having ac...
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JP2005198655A |
To provide an enzyme having a cephalosporin C acylase activity, a method of recombining a DNA for preparing the enzyme, a nucleotide sequence encoding the enzyme, an expression vector including the nucleotide sequence, a cell transformed...
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JP3633940B2 |
Substrates for beta -lactamase of general formula (I) in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); R' is selected from the group consisting of H, lower (i.e. alkyl of 1...
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JP2004538265A |
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula III:- into a 3-thiolated-alpha-ketoadipyl-7-aminocephalosporanic acid derivative o...
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JP2004537985A |
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula III:- into a 3-thiolated-alpha-ketoadipyl-7-aminocephalosporanic acid derivative o...
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JP3601846B2 |
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JP3574453B2 |
PCT No. PCT/EP94/02544 Sec. 371 Date May 13, 1996 Sec. 102(e) Date May 13, 1996 PCT Filed Jul. 29, 1994 PCT Pub. No. WO95/04149 PCT Pub. Date Feb. 9, 1995An overall efficient process for the preparation and recovery of 7-aminodesacetoxyc...
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JP2004524006A |
The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-beta-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention ...
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JP2004501619A |
A process for the preparation of biologically active compounds, wherein active substances having additional functional groups and a modified spectrum of activity and modified application properties are obtainable from medicinal substance...
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JP2004500826A |
The present invention concerns the direct production of desacetylcephalosporin C by culturing a strain of Acremonium chrysogenum containing recombinant nucleic acid encoding Rhodosporidium toruloides cephalosporin esterase.
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JP3476834B2 |
Process for producing the enzyme D-amino acid oxydase of Rhodotorula gracilis in host cells. The process for the expression of the enzyme comprises isolating the complementary DNA corresponding to the messager RNA of the gene which codes...
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JP3471393B2 |
PURPOSE: To control the size of a granule of a mold, increase the mass transfer rate of oxygen, a substrate, etc., enable the improvement in productivity of useful substances and further application to an efficient microbial treatment pr...
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JP2003527069A |
The invention provides DNA, heterologous host cells capable of transcribing, translating or expressing said DNA and methods employing such host cells and cultures thereof for an improved in vivo production of acylated cephalosporins with...
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JP3404406B2 |
PURPOSE: To obtain an Escherichia coli recombinant strain capable of producing- glutaryl-7ACA-acylase, substantially containing no β-lactamase activity to decompose 7-aminocephalosporanic acid. CONSTITUTION: Recombinant DNA technology r...
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JP2003512039A |
The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for...
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JP2002541812A |
An extracellular protease of Acremonium chrysogenum with CPC-acetylhydrolase activity and its use for the synthesis of deacetylated derivatives of cephalosporin C and inactivation of the gene for increasing the yield of cephalosporin. Th...
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JP2002316991A |
To provide the penicillin and cephalosporin causing no enzyme inhibition.The objective penicillin and cephalosporin includes phenylacetic acid or phenoxyacetic acid in an amount of ≤100 ppm.
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JP2002533092A |
The present invention discloses a process for the production of 7-amino cephalosporanic acid (7-ACA) or a derivative thereof comprising the steps of fermenting a P. chrysogenum strain being transformed with an expression construct compri...
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JP3321107B2 |
DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved i...
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JP2002509933A |
A method for the recovery of an N-substituted cephalosporanic acid compound of general formula (I), wherein R2 is selected from the group consisting of adipyl (1,4-dicarboxybutane), succinyl, glutaryl, adipyl, pimelyl, suberyl, 2-carboxy...
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JP2002509933A5 |
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JP2002501750A |
The present invention relates to a nucleic acid molecule which codes for the cephalosporin acetylesterase from Bacillus subtilis ATCC 6633 (DSM 11909), vectors and host cells which comprise such a nucleic acid molecule, a process for the...
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JP2002500015A |
Three-dimensional crystal structure(s) of deacetoxycephalosporin C synthase (DAOCS) are described. The X-ray co-ordinates provide precise 3-dimensional information of amino acids within the structure of DAOCS. Some of these are in comple...
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JP2002000266A |
To provide an immobilized enzyme capable of industrially hydrolyzing 7-aminocephalosporanic acid in high efficiency.The immobilized enzyme is acetyl hydrolase derived from Bacillus subtilis and immobilized on N,N'-methylene-bis(methacryl...
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