Title:
METABOLIC ENGINEERING OF XYLOSE FERMENTING EUKARYOTIC CELL
Document Type and Number:
Japanese Patent JP2013055948
Kind Code:
A
Abstract:
To provide eukaryotic host cells, such as fungal host cells, that are transformed with an XI gene that confers the ability to grow on xylose and which host cells have specific rates of xylose consumption and/or product (ethanol) formation that are compatible with commercial application of the host cells.
The host cell of yeasts or filamentous fungi transformed with a nucleic acid construct comprising a nucleotide sequence encoding a xylose isomerase comprising an amino acid sequence that has at least 85% sequence identity with a specific amino acid sequence. The ability of directly isomerizing xylose to xylulose is conferred to the host cell immediately after the transformation of the host cell with a nucleic acid construct.
Inventors:
WINKLER AARON ADRIAAN
KUYPER SIPKO MAARTEN
DE LAAT WILHELMUS THEODORUS ANTONIUS MARIA
VAN DIJKEN JOHANNES PIETER
PRONK JACOBUS THOMAS
KUYPER SIPKO MAARTEN
DE LAAT WILHELMUS THEODORUS ANTONIUS MARIA
VAN DIJKEN JOHANNES PIETER
PRONK JACOBUS THOMAS
Application Number:
JP2012243697A
Publication Date:
March 28, 2013
Filing Date:
November 05, 2012
Export Citation:
Assignee:
TECH UNIV DELFT
International Classes:
C12N1/19; C12N1/15; C12N1/18; C12P1/06; C12P5/00; C12P7/00; C12P7/06; C12P7/08; C12P7/18; C12P7/20; C12P7/42; C12P7/46; C12P7/48; C12P7/54; C12P7/56; C12P13/04; C12P35/00; C12N15/09
Domestic Patent References:
| JP2008506383A | 2008-03-06 |
Foreign References:
| WO2004099381A2 | 2004-11-18 | |||
| WO2003062430A1 | 2003-07-31 |
Other References:
JPN6010072647; ＦＥＭＳ． Ｙｅａｓｔ． Ｒｅｓ． Ｖｏｌ． ２, 2002, ｐ． ２７７-２８２
JPN6010072646; Ｅｎｚｙｍｅ． Ｍｉｃｒｏｂ． Ｔｅｃｈｎｏｌ． Ｖｏｌ． ３２, 2003, ｐ． ５６７-５７３
JPN6010072651; Ａｐｐｌ． Ｅｎｖｉｒｏｎ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ． ６１， Ｎｏ． １２, 1995, ｐ． ４１８４-４１９０
JPN6010072645; ＦＥＭＳ． Ｙｅａｓｔ． Ｒｅｓ． Ｖｏｌ． ４, 2003, ｐ． ６９-７８
JPN6012006556; Ｐｒｏｔｅｉｎ， Ｔｈｅ Ｎａｔｉｏｎａｌ Ｃｅｎｔｅｒ ｆｏｒ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｉｎｆｏｒｍａｔｉｏｎ， Ａｃｃｅｓｓｉｏｎ Ｎｏ． ＮＰ＿８０９７０６， ［ｏｎｌｉｎｅ］ , 2003
JPN6015012855; 'ＦＥＭＳ． Ｙｅａｓｔ． Ｒｅｓ' Ｍａｒ．２００４，Ｖｏｌ．４， Ｐ．６５５-６６４
JPN6010072646; Ｅｎｚｙｍｅ． Ｍｉｃｒｏｂ． Ｔｅｃｈｎｏｌ． Ｖｏｌ． ３２, 2003, ｐ． ５６７-５７３
JPN6010072646; Ｅｎｚｙｍｅ． Ｍｉｃｒｏｂ． Ｔｅｃｈｎｏｌ． Ｖｏｌ． ３２, 2003, ｐ． ５６７-５７３
JPN6010072651; Ａｐｐｌ． Ｅｎｖｉｒｏｎ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ． ６１， Ｎｏ． １２, 1995, ｐ． ４１８４-４１９０
JPN6010072645; ＦＥＭＳ． Ｙｅａｓｔ． Ｒｅｓ． Ｖｏｌ． ４, 2003, ｐ． ６９-７８
JPN6012006556; Ｐｒｏｔｅｉｎ， Ｔｈｅ Ｎａｔｉｏｎａｌ Ｃｅｎｔｅｒ ｆｏｒ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｉｎｆｏｒｍａｔｉｏｎ， Ａｃｃｅｓｓｉｏｎ Ｎｏ． ＮＰ＿８０９７０６， ［ｏｎｌｉｎｅ］ , 2003
JPN6015012855; 'ＦＥＭＳ． Ｙｅａｓｔ． Ｒｅｓ' Ｍａｒ．２００４，Ｖｏｌ．４， Ｐ．６５５-６６４
JPN6010072646; Ｅｎｚｙｍｅ． Ｍｉｃｒｏｂ． Ｔｅｃｈｎｏｌ． Ｖｏｌ． ３２, 2003, ｐ． ５６７-５７３
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Mari Yuge
Yukihiro Ikeda
Hajime Asamura
Mari Yuge
Yukihiro Ikeda