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JP2001526060A |
The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate these drugs locally, and to overcome the r...
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JP3239359B2 |
To obtain a new DNA fragment comprising a DNA fragment having a promoter active part of an alkali protease gene of Acremonium chrysogenum and useful for production, etc., of 7-aminocephem compound for antibiotic raw materials. This new D...
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JP2001521441A |
The uses is claimed of: (i) aerogels (AG) for adsorption from a liquid phase; (ii) hydrophilic or hydrophobic AG as adsorbents; and (iii) adsorbents containing AG (not as a mixture with activated carbon or active alumina) for adsorption ...
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JP2001515715A |
A process for decreasing esterase activity present in the presence of D-amino add oxidase activity or in the presence of glutarylacylase activity in a mixture having esterase activity and D-amino acid oxidase activity and/or having ester...
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JP2001515729A |
A first compound is converted to a second compound enzymatically in a solvent mixture containing water and a fluorinated, non-chlorinated alkane, alkene, or alkyne having up to 4 carbon atoms. Lactams, for example 6-aminopenicillanic aci...
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JP2001515521A |
The present invention discloses a method for topical application of an enzyme, wherein the enzyme becomes incorporated in a peelable film, for instance a polyvinyl alcohol film, after its application. In this way, the release of enzyme-c...
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JP3195058B2 |
PURPOSE: To efficiently obtain the subject compound useful for a raw material of an antibacterial agent, etc., without using any toxic solvent or reagent by selectively deacylating 7-acylamino-cephalosporanic acid with a microorganism be...
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JP2001186894A |
To provide a method for directly producing 7-aminocephem compound by using a microorganism. A cephalosporin C acylase gene is cloned from Acremonium chrysogenum and the chemical structure is elucidated to construct the vector for express...
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JP2001507927A |
A three-dimensional structure is described of a complex of isopenicillin N synthase (IPNS) with Fe and its substrate ACV. This structure is used to design modified enzymes IPNS, DAOCS, DACS, DAOC/DACS and other related enzymes of the pen...
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JP2001506868A |
Enzymatic process for the preparation of cephalosporanic 7 beta -(4-carboxybutanamide) acid by using the modified enzyme D-aminoacid oxidase of Trigonopsis variabilis produced in Escherichia coli. The process for the expression of the en...
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JP2001506131A |
The present invention discloses a fermentative process for the production of penicillin G or V or cephalosporin G or V derivatives wherein certain derivatives of phenylbutyric acid are used as a side chain precursor. In said phenylbutyri...
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JP3131024B2 |
Described is a process for the enzymatic production of cephalosporane derivatives, or their salts, having the formula (I): wherein R represents a -CO-COOH or -COOH group and R' is H, OH or -O-CO-R'', R'' being a C1-C4 alkyl group, includ...
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JP3126031B2 |
An enzymatic means for hydrolyzing the ester of certain cephalosporins is provided herein.
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JP3115593B2 |
beta -Lactam derivatives are synthesized by an enzymatic reaction of the parent amino beta -lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of beta -lactam derivative in the ...
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JP3117092B2 |
A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephal...
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JP2000516215A |
Disclosed is a process for the synthesis of beta -lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.
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JP2000514301A |
An improved process for production of an N-acylated cephalosporin is described. The process utilizes an Acremonium strain which has been modified to express an acyl transferase of a filamentous fungus and is selected for production of th...
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JP2000512860A |
The invention relates to a method for preparing a beta-lactam antibiotic, wherein an N-substituted beta-lactam, having general formula (I), wherein R0 is hydrogen or C1-3 alkoxy; Y is CH2, oxygen, sulfur, or an oxidized form of sulfur; Z...
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JP2000512510A |
The present invention relates to a novel process for the preparation of cephalosporins having been deacylated at the 7-amino group, by fermentation of a cephalosporin producing microorganism in the presence of a side chain precursor, ext...
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JP2000512512A |
The present invention disclosures a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
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JP2000512511A |
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
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JP2000509613A |
The invention relates to promoters of the genes glutamate dehydrogenase, beta-acetylhexosaminidase and gamma-actin and their use in systems of expression, secretion and anti-sense of filamentary fungi. The invention also relates to the u...
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JP3072101B2 |
(A) A novel process for preparing 7-aminodesacetoxy cephalsporanic acid (7-ADCA) is claimed comprising (a) maintaining in a culture medium capable of sustaining its growth, a strain of Penicillium chrysogenum (PC) which produces isopenic...
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JP3057759B2 |
A process for producing 7-aminocephem compounds, or salts thereof, which comprises cultivating in a nutrient medium a microorganism capable of producing a 7-aminocephem compound of the formula: wherein R is acetoxy, hydroxy or hydrogen, ...
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JP3030982B2 |
PURPOSE: To provide the subject acylase having a specific molecular weight, a specific amino acid sequence and excellent thermal stability, capable of converting glutaryl 7-ACA, etc., into aminocephalosporanic acid and useful for the pro...
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JP3027847B2 |
(A) A novel process for preparing 7-aminodesacetoxy cephalsporanic acid (7-ADCA) is claimed comprising (a) maintaining in a culture medium capable of sustaining its growth, a strain of Penicillium chrysogenum (PC) which produces isopenic...
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JP3016449B2 |
A cephalosporin C acylase with the following characteristics: (a) has ability to catalyze the enzymatic conversion of cephalosporin C, glutaryl 7-ACA, adipyl 7-ACA, succinyl 7-ACA, N-acetylcephalosporin C, N-benzoylcephalosporin C and ce...
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JP2980689B2 |
PCT No. PCT/KR95/00095 Sec. 371 Date Jun. 16, 1997 Sec. 102(e) Date Jun. 16, 1997 PCT Filed Jul. 31, 1995 PCT Pub. No. WO96/12031 PCT Pub. Date Apr. 25, 1996A process for the isolation of cyclosporin A comprising the steps of: adding a l...
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JP2930546B2 |
To obtain a new protein obtained from a DNA sequence having a configuration of a specific restriction cite cloned to a plasmid derived from Streptomyces, involving biosynthesis of a β-lactam compound and usable for synthesis of an antim...
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JP2928884B2 |
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JPH11507062A |
Process for purifying 7-substituted aminodeacetoxycephalosporins through the use of filter membranes. A process for purification by ultrafiltration and/or nanofiltration with a cut-off for molecular weights over 10,000 Dalton and prefera...
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JP2896795B2 |
A promoter of a glyceraldehyde-3-phosphate dehydrogenase gene of Acremonium chrysogenum and a transformant which is obtained by using the expression plasmid containing the promoter and is capable of producing a cephalosporin are disclosed.
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JPH11505726A |
PCT No. PCT/EP96/02434 Sec. 371 Date Feb. 18, 1998 Sec. 102(e) Date Feb. 18, 1998 PCT Filed Jun. 3, 1996 PCT Pub. No. WO96/38580 PCT Pub. Date Dec. 5, 1996A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosp...
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JP2883173B2 |
A method for deactivation of esterase enzyme and an improved enzymatic process for the oxidation of Cephalosporin C to glutaryl-7-ACA.
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JP2876652B2 |
PURPOSE:To obtain D-amino acid oxidase(DAO) useful for organizing DAO manifestation vector, showing catalytic activity to catalyze conversion of cephalosporin C to a specific cephalosporanic acid derivative and having specific peptide se...
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JPH11503408A |
The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any s...
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JP2851021B2 |
Transformation of Cephalosporin C or its derivatives and salts into 7-aminocephalosporanic acid or its derivatives by an enzymatic two stage process with enzymes immobilized on a solid matrix.
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JPH10510993A |
An enzyme preparation that exhibits cephalosporin haloperoxidase activity is isolatable from a microorganism species of the Rathayibacter genus. This enzyme preparation can convert cephalexin to a halogenated cephalosporin antibiotic in ...
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JP2816167B2 |
gamma -Glutamyltranspeptidase, which can be prepared by fermentation, can be used to hydrolyse alpha -aminoadipinyl-monoamino compounds, especially D-( delta )- alpha -aminoadipinyl-7-aminocephalosporanic acid.
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JP2805594B2 |
The present invention relates to a process for producing large amounts of 7 beta -(4-carboxybutanamido)-cephalosporanic acid acylase ("GA") enzyme, which process consists in growing, under suitable culture conditions, a recombinant Esche...
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JPH10175980A |
To efficiently obtain a compound useful as the subject intermediate in high purity and yield by deacylating a compound formed by reaction between each specific glutaryl aminocephalosporanic acid and thiol. In the form of an aqueous solut...
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JP2769279B2 |
PURPOSE: To breed a microbial strain having increased D-amino acid oxidase activity and reduced esterase activity by a gene recombination method characterized by the use of Trigonopsis variabilis as a host. CONSTITUTION: A process for tr...
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JPH10506287A |
The present invention relates to the biosynthesis of beta-lactam antibiotics. More specifically, the invention relates to processes of producing beta-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of...
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JPH10101679A |
To simply obtian the subject compound useful for antibiotics, etc., by reacting a 7-protected amino-3-halogenomethyl-cephem carboxylic acid ester with a 5-mercaptothiazole compound and subsequently reacting the reaction product with a te...
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JPH09512170A |
(57) Isolation refining of the DNA which carries out the code of the second-half enzyme which participates in composition of summary antibiotic セファマイシン was carried out. This specific enzyme participates in the second-half s...
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JP2655790B2 |
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum str...
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JP2651288B2 |
A cephalosporin acetylhydrolase gene, a recombinant DNA molecule prepared by introducing said gene into a vector used in an E. coli host-vector system, E. coli cells transformed with said recombinant DNA molecule, a protein having the am...
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JPH09505732A |
PCT No. PCT/JP94/01799 Sec. 371 Date May 1, 1996 Sec. 102(e) Date May 1, 1996 PCT Filed Oct. 26, 1994 PCT Pub. No. WO95/12680 PCT Pub. Date May 11, 1995A mutant CC acylase wherein at least one amino acid at the Ala49, Met164, Ser166, Met...
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JPH09503907A |
(57) [Summary] Acyltransferase Takashi 7-amino via 2- (carboxyethylthio) acetyl-7-ADCA and 3- (carboxymethylthio) propionyl-7-ADCA using a penicillium chrysogenum transformant that expresses the expanding enzyme. Provided is an efficient...
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JPH08256789A |
To efficiently obtain the subject antibiotic substance without generating by products by reacting 6-aminopenicillanic acid or 7-aminocephalosporanic acid with amides in the presence of a penicillin acrylase and an enzyme inhibitor under ...
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