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JPS57170188A |
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JPS5742318B2 |
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JPS5735960B2 |
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JPS5735959B2 |
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JPS5733036B2 |
7-(3-Alkanesulphonamidophenyl-D-glycinamido)-3-methyl-3-ceph
em-4-- carboxylic acid of formula (I) or its salts, is prepd. by reacting 7-amino-3-methyl-3-cephem-4-carboxylic acid (II) or its salt with 3-alkanesulphonamidophenyl-glycine (...
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JPS5733038B2 |
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JPS5733039B2 |
The cell substance or enzyme preparations of the yeast Trigonopsis variabilis oxidise the 7 beta -side chain of 3-(X-methyl)-7 alpha -methoxy- 7 beta -(5-amino-5-carboxyvaleramido)-3-cephem-4-carboxylic acids, X being acetoxy, carbamoylo...
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JPS5733037B2 |
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JPS57110189A |
The microorganism Streptomyces capillispira, NRRL 12279, produces an enzyme which deesterifies cephalosporin methyl esters.
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JPS5730479B2 |
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JPS5724118B2 |
7-Amino- DELTA <3>-cephem derivatives of the following formula are prepared, in which the substituents are as defined in Claim 1. The said cephem derivatives are obtained by bringing an appropriately substituted acetamidodesacetoxycephal...
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JPS5722559B2 |
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JPS5721993B2 |
A process for the N-deacylation of a 7 beta -phenoxyacetamido cephalosporin which comprises subjecting the cephalosporin to the action of an amidohydrolase enzyme which is derived from a bacterial source, e.g. Erwinia aroideae, which is ...
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JPS5721994B2 |
1448419 Making enzymes; binding them to polymers BAYER AG 1 Nov 1974 [3 Nov 1973] 47362/74 Heading C3H [Also in Division C2] Penicillin acylase is covalently bonded to a cross-linked copolymer of the composition: (A) 0À1 to 50 wt. per c...
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JPS5721318B2 |
N-(4-chlorobenzoyl)- and N-(2,4-dichlorobenzoyl)-cephalosporin C values are useful in processes for separating the cephalosporin C values for polysaccharide and proteinaceous impurities present in fermentation liquors. These new intermed...
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JPS5765200A |
PURPOSE: To purify a cephalosporin compound, in high efficiency, by adsorbing the cephalosporin compound to a polymeric azo-dye adsorbent in dark; and desorbing the compound under light irradiation. CONSTITUTION: A solution containing a ...
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JPS5718880B2 |
A method of production of the antibiotic y-g19zd3, a compound of the group of 7-methoxycephalosporins, and their pharmaceutically acceptable salts, which in their most purified state: (a) is a white amorphous powder of amphoteric charact...
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JPS5718878B2 |
This invention relates to a process for preparing a cephamycin type antibiotic substance which comprises cultivating a microorganism belonging to the genus Streptomyces under aerobic conditions and a primary object of this invention is t...
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JPS5718879B2 |
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JPS5718476B2 |
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JPS5718475B2 |
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JPS5762286A |
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JPS5747490A |
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JPS5713280B2 |
Novel 7-(5-amino-5-carboxyvaleramido)-7-methoxy-3-hydroxymethyl-3-
cephem-4-c arboxylic acid derivatives. Such derivatives are prepared by subjecting cephamycin type compounds to the action of esterase enzyme of mold fungi.
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JPS5736995A |
PURPOSE: To prepare the titled substance useful as a raw material of 7-methoxycephalosporin derivative, from the cultured product obtained by the cultivation of bacteria capable of producing the titled substance and belonging to Streptom...
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JPS577718B2 |
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JPS577719B2 |
Cephalosporin C is produced in remarkably increased yields by fermentation process using a cephalosporin C-producing polyploid mold belonging to the genus Cephalosporium.
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JPS577720B2 |
A new process for the production of Cephalosporin C (CPC) in which a polyene-antibiotics-resistant mold of the genus Cephalosporium is employed and an increased yield is attained.
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JPS574237B2 |
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JPS5653990B2 |
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JPS5652912B2 |
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JPS56152478A |
NEW MATERIAL:Optically active cephalosporin analogs of formula I (R1 is H, lower alkyl, lower acyl; R2 is H, ester residue; H atoms on the 6 and 7 positions are in cis) and their salts. EXAMPLE: (4S,6R,7S)-7-amino-4-hydroxy-1-azabicyclo[...
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JPS56151497A |
PURPOSE: Immobilized microorganism cells are used to effect the reaction between D-p-hydroxyphenylglycine and 6-aminopenicillanic acid of the formula, thus producing the objective compound readily in high yield. CONSTITUTION: A water-sol...
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JPS5648158B2 |
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JPS5646839B2 |
3-Hydroxymethylceph-3-em-4-carboxylic acids are prepared by esterase-catalysed hydrolysis from the corresponding 3-acyloxymethylceph-3-em-4-carboxylic acids. The esterase used for this purpose is obtained by cultivation of a microorganis...
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JPS5635159B2 |
PURPOSE:7-Methoxycephalosporins of the formula II (R is heterocyclic thiols of the formula I, e.g. residue of 5-mercapto-1,3,4-thiadiazole-2-thioacetic acid of the formula III, or 5-mercapto-1-methyl-1H-tetrazol of the formurla IV).
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JPS5632316B2 |
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JPS5690090A |
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JPS5629999B2 |
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JPS5628520B2 |
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JPS5664795A |
PURPOSE: To prepare an optical isomer of a cephalosporin analog and a salt thereof having a powerful antimicrobial activity, by reacting the cephalosporin analog with a di-substituted carboxylic acid in the presence of a microorganism. C...
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JPS5621395B2 |
Prismatic crystals of cephalexin (I) monohydrate (7-(D-alpha-aminophenylacetamido)-3-methyl-3-cephem-4-carbox
ylic acid H2O) are prepd. by concentrating, pref. at pH 1-3, an aq. soln. contg. (I) prepd. by enzymatic reaction of 7-aminodes...
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JPS5619999B2 |
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JPS5645196A |
PURPOSE: To prepare a β-lactam antibacterial agent continuously, in high efficiency, by reacting an ester having a specific structural formula with an aminoazetidinonecarboxylic acid having a specific structural formula in an aqueous so...
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JPS5630988A |
PURPOSE: To obtain the titled compound useful as a synthetic intermediate for a drug, by reacting a novel 7-methoxy-3-substituted cinnamoyloxymethylcephalosporin having high stability obtained from a culture of a specific bacterium with ...
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JPS5611440B2 |
A novel antibiotic C-2801-X represented by the formula is produced by cultivating a microorganism of the genus Streptomyces. The compound is useful in the treatment of mammals, including human beings, suffering from urinary tract infecti...
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JPS569920B2 |
Increased yields of the known and useful antibiotic cephamycin C [7-(D-5-amino-5-carboxyvaleramido)-3-(carbamoyloxymethyl)-7-
methoxy-3- cephem-4-carboxylic acid] are obtained by the addition of D-lysine or DL-lysine to fermentation medi...
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JPS5549840B2 |
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JPS5548800B2 |
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JPS5548797B1 |
1385943 Cephalosporin compounds TAKEDA YAKUHIN KOGYO KK 4 April 1972 [2 April 1971] 15298/72 Heading C2C [Also in Division C3] Cephalosporin compounds of Formula (I): wherein R is an optionally substituted, sixmembered carbocyclic or fiv...
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