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JPS5548798B2 |
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JPS5548799B2 |
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JPS55143996A |
NEW MATERIAL:7α-Methoxy-7β-[( 5-carbamoylmethylamino )adipoylamino]-3- carbamoyl-oxymethyl-3-cephem-4-carboxylic acid (salt) of formula. USE: Antibacterial agent effective to Gram-positive and Gram-negative bacteria, especially to Esch...
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JPS55138396A |
PURPOSE: Optically active cephalosporin analogs or their salts are produced by use of the culture mixture of a specific microorganism or it processed product. CONSTITUTION: The reaction between a compound of formula II (R1 is residue of ...
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JPS5535119B2 |
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JPS5535118B1 |
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JPS55114297A |
PURPOSE: An optically inactive β-lactam type antibiotic is acylated by the action of a specific microorganism to produce an optically active β-lactam type biotic. CONSTITUTION: The reaction between an acid of formula I (R is acyl group...
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JPS55108872A |
NEW MATERIAL:Optically active cephalosporin analogs of formula I (R1 is H, lower alkyl; R2 is H, residual group of ester hydrogen atoms in the 6 and 7 positions are in cis configuration.) and their salts. EXAMPLE: (+)-7β-Amino-1-azabicy...
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JPS5529680B2 |
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JPS5525195B2 |
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JPS5513719B2 |
Cephalosporins of the formula WHEREIN R stands for a six-membered cyclic hydrocarbon residue which is either substitued or unsubstituted and either saturated or unsaturated, or an unsaturated five-membered heterocyclic residue containing...
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JPS5523966A |
PURPOSE: Cephalosporin compounds or their salts are produced using the culture medium, cells or their processed product of a bacterium producing D-aminoacid oxidase, which belongs to Candida. CONSTITUTION: The culture medium of a bacteri...
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JPS552959B2 |
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JPS552958B2 |
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JPS553750A |
PURPOSE: To obtain high-purity cephamycin C effectively, by removing inorganic ions from a cephamycin C-containing medium through electrodialysis with an ion exchange membrane without inactivating the antibiotic, and by selectively adsor...
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JPS557A |
PURPOSE: In the presence of the culture mixture of Arthrobacter bacterium or its treated product, 1H-tetrazole-1-yl-acetyl group is introduced in the 7-amino group on 7-aminocephem compound to produce ceftezole used for an antibiotic in ...
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JPS5443598B2 |
3-Acyloxymethylceph-3-em-4-carboxylic acids, for example cephalosporin C, are enzymically deacylated to their 3-hydroxymethyl analogues by means of esterases produced by culturing a yeast microorganism or a mutant thereof of the genus Rh...
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JPS5443080B2 |
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JPS5439473B2 |
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JPS5437238B2 |
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JPS5437237B2 |
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JPS5431078B2 |
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JPS5431080B2 |
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JPS5431077B2 |
1389714 Producing cephalosporin C and helvolic acid TAKEDA YAKUHIN KOGYO KK 15 Nov 1972 [15 Nov 1971] 52741/72 Headings C2C and C2U Cephalosporin C and helvolic acid are produced by aerobically cultivating the new microorganism Cephalosp...
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JPS5431079B2 |
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JPS5429517B2 |
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JPS54119094A |
PURPOSE: To provide a novel strain of fungus producing an antibiotic substance, cephamycin C. CONSTITUTION: Streptomyces todorominensis sp. nov. (no sporangium, no flagellum spore, no sclerotium, smooth spore surface, optimum temp. to gr...
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JPS54101490A |
A process for the recovery of cephalosporin C comprises (a) contacting a fermentation broth containing cephalosporin C with an anion exchange resin which is either a weak-base resin in the weak acid salt form or free base form or a stron...
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JPS5421437B2 |
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JPS5492693A |
PURPOSE: To prepare a cephalosporin derivative by reacting D-p-hydroxyphenylglycine with a 7-aminocephalosporanic acid derivative in the presence of specific microorganisms. CONSTITUTION: A cephalosporin derivative of formula II (R1 is H...
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JPS5418354B2 |
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JPS5417834B2 |
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JPS5417833B2 |
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JPS5417029B2 |
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JPS5417032B2 |
7-Amino-cephem compounds are produced from 7-substituted-cephem compounds by the enzymatic action of microorganisms Comamonas sp. SY-77-1 FERM-P 2410 or Pseudomonas ovalis ATCC 950.
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JPS5417030B2 |
A new method for production of a cephalosporin ester (I) which comprises reacting a derivative of an organic acid (II) with a 7-aminocephem compound (III) in the presence of an enzyme of a microorganism of one of the genera Escherichia, ...
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JPS5417031B2 |
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JPS5416922B1 |
The isolation of cephalosporin C from solutions containing it in admixture with impurities stemming from the fermentation broth by adsorption on macroporous, non-ionic adsorption resins with large surface.
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JPS5473192A |
A novel process for obtaining cephalosporin C and the salts and derivatives thereof from culture filtrates or culture solutions is provided which comprises drying the culture filtrate or culture solution, dissolving it in an optionally w...
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JPS5413514B1 |
1348359 Enzymatic preparation of cepnalosporins and penicillins SNAM PROGETTI SpA 27 April 1972 [28 April 1971] 19726/72 Heading C2A [Also in Division C3] The invention comprises a process for the treatment of a substance which contains ...
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JPS5467097A |
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JPS5411400B2 |
1433528 Producing deacetylcephalosporin C TAKEDA YAKUHIN KOGYO KK 16 April 1973 [15 April 1972] 18222/73 Heading C2C Deacetylcephalosporin C is produced by cultivating a micro-organism which belongs to the genus Cephalosporium and is cap...
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JPS5459397A |
PURPOSE: To prepare cefazolin by the enzymatic acylation of a cephem derivative. CONSTITUTION: 7-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephe
m-4- carboxylic acid is acylated with 1H-tetrazol-1-acetic acid or its reactive d...
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JPS548754B2 |
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JPS5441388A |
PURPOSE: To prepare cephradine useful as an antibacterial agent, by the acylation of 7-aminodesacetoxycephalosporanic acid (7-ADCA) in the presence of an acylase produced by bacteria belonging to Acetobacter genus. CONSTITUTION: Cephradi...
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JPS5437887A |
PURPOSE: To prepare the title compound economically, by the reaction of 7-aminocephalosporanic acid with 2-thienyl acetic acid in the presence of acylase derived from bacteria belonging to Arthrobacter genus.
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JPS5435291A |
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JPS5432694A |
PURPOSE: To obtain high-purity title compounds in high yield by treating in the presence of H2O2 7β-(5-amino-5-carboxyvaleramido)-7α-methoxy-3 - cephem - 4 - carboxylic accid with microorganism cells having activity to oxidases for D-a...
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JPS5411298A |
PURPOSE: To prepare 3-heterocyclic thiomethylcephalosporins by the cultivation of microbials producing cephalosporin-type antibigtic, in the presence of a heterocyclic thiol.
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JPS53133690A |
PURPOSE: To provide a highly acylated title compound at relatively low temperature, by reacting 7-amino-3-cephem derivative with D-mandelic acid or its reactive derivative in an aqueous medium containing specific bacteria belonging to Ar...
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