Japanese Patent JPS5513719

B2

Cephalosporins of the formula WHEREIN R stands for a six-membered cyclic hydrocarbon residue which is either substitued or unsubstituted and either saturated or unsaturated, or an unsaturated five-membered heterocyclic residue containing one hetero-atom in its ring; R1 stands for a hydrogen atom or -OR2 wherein R2 is an organic group; n is 1 or 2; and X is -OR3, -SOmR3, -NH2 or -CN, where R3 stands for an alkyl group of 1 to 3 carbon atoms or a phenyl group and m is 0, 1 or 2, are produced by condensation between (1) an alpha -substituted- alpha -amino acid of the formula WHEREIN R has the aforementioned significance, or its reactive derivative and (2) a 7-aminocephem compound of the formula WHEREIN R1, n an X have the aforementioned significances through the utilization of a microorganism having a cephalosporin-synthesizing activity.

JPS54148795	77*22*OMEGAA*1*33DITHIOLANEE22IMINO* SUBSTITUTED*ACETYLAMINO*CEPHALOSPORANIC ACID DERIVATIVE
WO/2011/042776	PROCESS FOR PREPARATION OF CEFOTAXIME ACID AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
WO/1996/012712	REACTIVE PHOSPHATE DERIVATIVES OF THIAZOLYLACETIC ACID AND PROCESS FOR PREPARING CEPHALOSPORIN ANTIBIOTICS USING THE SAME

JP12220672A

April 10, 1980

December 06, 1972

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C07D501/06; C07D501/20; C12P35/04

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