Title:
セファクロルの合成方法
Document Type and Number:
Japanese Patent JP5022913
Kind Code:
B2
Abstract:
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D-phenylglycine in activated form (PGa) in the presence of an enzyme in a reaction mixture to form cefaclor, wherein at least part of 7-ACCA and/or PGa are added to the reaction mixture during the course of the reaction. The invention also relates to an aqueous mixture comprising an amount of cefaclor of >10 (w/w) %, an amount of 7-amino-3-chloro cephalosporanic acid of <2 (w/w) %, and an amount of D-phenyl glycine of <2 (w/w) % and a process for the recovery of cefaclor from this aqueous mixture. The invention also relates to cefaclor in crystal form having an absorbance at 400 nm (A400) of less than 0.250.
Inventors:
Moody, Harold, Monroe
Doolen, Van, Theodorus, Johannes, Godfreyde, Maria
Doolen, Van, Theodorus, Johannes, Godfreyde, Maria
Application Number:
JP2007548813A
Publication Date:
September 12, 2012
Filing Date:
December 23, 2005
Export Citation:
Assignee:
DSM Sinochem Pharmaceuticals Netherlands B.V.
International Classes:
C12P35/04
Domestic Patent References:
| JP2001503272A |
Foreign References:
| US6287799 | ||||
| WO2003055998A1 |
Attorney, Agent or Firm:
Yuichi Yamada