Title:
α-ケト酸誘導体を使用して3-セファロスポラン酸誘導体を製造する方法
Document Type and Number:
Japanese Patent JP2004538265
Kind Code:
A
Abstract:
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula III:- into a 3-thiolated-alpha-ketoadipyl-7-aminocephalosporanic acid derivative of formula IV: wherein R is a heterocyclic group comprising at least a nitrogen atom. Compounds of formula IV are used in the preparation of cephalosporin C antibiotics and derivatives thereof.
Inventors:
Sanchez-Ferrer, Alvaro
Lopez-Mass, Jose Aniseto
Garcia-Carmona, Francisco
Lopez-Mass, Jose Aniseto
Garcia-Carmona, Francisco
Application Number:
JP2002583440A
Publication Date:
December 24, 2004
Filing Date:
April 18, 2002
Export Citation:
Assignee:
BIOFERMA MURCIA,S.A.
International Classes:
C07D498/04; C07D501/00; C07D501/04; C07D501/12; C12P35/06; C07D501/14; C07D501/18; C07D501/36; C12P35/02; (IPC1-7): C07D501/04; C07D501/18; C07D501/36; C12P35/06
Attorney, Agent or Firm:
Akira Kano