Title:
【発明の名称】セファロスポリンの発酵製造の新規な方法
Document Type and Number:
Japanese Patent JP2002509933
Kind Code:
A
Abstract:
A method for the recovery of an N-substituted cephalosporanic acid compound of general formula (I), wherein R2 is selected from the group consisting of adipyl (1,4-dicarboxybutane), succinyl, glutaryl, adipyl, pimelyl, suberyl, 2-carboxyethyithio)acetyl, 3-carboxyethylthio)propionyl, higher alkyl saturated and higher alkyl unsaturated dicarboxylic acids, from a complex mixture comprising in addition to the compound of general formula (I) 6-aminopenicillanic acid (6-APA) and optionally one or more N-substituted penicillanic acid compounds, comprising the steps of: (a) acidifying the complex mixture to a pH below 6.5 and maintaining the mixture below said pH at a temperature of between 10° C. and 150° C.; and/or (b) contacting the complex mixture with a carbon dioxide source; and (c) recovering the cephalosporanic acid compound of formula (I) from the mixture obtained after steps (a) and/or (b).
Inventors:
Bohers Ilko Adrianis Lambertus Anthony
Fundesando Emilius Johannes Albertus The Velius
Shippel Dick
Fundesando Emilius Johannes Albertus The Velius
Shippel Dick
Application Number:
JP2000541174A
Publication Date:
April 02, 2002
Filing Date:
March 26, 1999
Export Citation:
Assignee:
DSM NEAMLOZE VENNOOTSHAP
International Classes:
A61K31/545; A61K31/546; B01D15/08; C07D463/02; C07D463/06; C07D463/20; C07D501/12; C07D505/02; C07D505/06; C07D505/20; C12P17/18; C12P35/00; C12P35/08; (IPC1-7): C07D501/12; A61K31/545; B01D15/08; C12P35/00
Attorney, Agent or Firm:
Minoru Nakamura (10 outside)