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WO/2024/050331A3 |
Described and featured herein are methods to barcode nucleic acids for detection and sequencing, particularly at a single cell level. The methods involve application of a barcode template in a compartment with various targets, including ...
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WO/2024/097970A1 |
Methods and materials for improving outcomes for ex vivo perfused organs are provided herein. For example, this document provides methods and materials that can be used to assess and treat lungs during ex vivo perfusion prior to transpla...
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WO/2024/059528A3 |
The digital amplification methods and kits provide the ability to estimate the fetal fraction of cell-free DNA (cfDNA) in a maternal sample, e.g., plasma or serum, by analysis of target sites that are differentially methylated in fetal a...
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WO/2024/093522A1 |
The present disclosure relates to methods, compositions, and kits for concentrating and purifying one or more target analyte (s) from a bulk fluid sample. In some embodiments, the methods involve at least two first aqueous two-phase syst...
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WO/2024/095238A1 |
Provided is a magnetosome comprising a doped mineral. Further provided is method for large-scale production of magnetosomes comprising a doped mineral, the method comprising maintaining in a fermentation vessel under continuous fermentat...
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WO/2024/097899A1 |
Polynucleotides, expression constructs, compositions, kits and method relating to genetic disorders are disclosed. Some embodiments provided herein encompass variants of a protein that relate to a genetic disorder. Also contemplated are ...
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WO/2024/059581A3 |
The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the ...
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WO/2024/092740A1 |
Provided is a method for detecting intercellular interaction. The method comprises: (1) preparing a first cell expressing a TCR activation response element and a reporter molecule, the first cell expressing a TCR; (2) co-incubating an an...
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WO/2024/036319A3 |
A system for detecting multiple target polynucleotides in a sample, comprising: a RNA-guided nuclease; a plurality of guide molecules, each comprising a sequence capable of binding a target polynucleotide in the sample; and a plurality o...
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WO/2024/093523A1 |
The present disclosure relates to methods, compositions, and kits for isolating target nucleic acids below a target size from a sample comprising nucleic acid components. In some embodiments, the methods involve one or more aqueous two-p...
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WO/2024/096125A1 |
The present disclosure provides a technique for efficiently designing or producing a bacterial preparation utilizing a bacterium capable of exhibiting a desired trait or a desired efficacy. More specifically, the present disclosure provi...
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WO/2024/095564A1 |
Provided is a method for estimating the metabolic flux distribution of cells, the method comprising: a step for acquiring discharge data including time-series data of a substance discharged to the outside of the cells with respect to a f...
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WO/2024/059719A3 |
The present invention provides optimized template switching oligonucleotides, methods, and kits for performing reverse transcription. The optimized template switching oligonucleotides include modifications of the 5' and 3' ends to preven...
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WO/2024/095262A1 |
An interlaced (in silico/in vitro) pipeline for rapid and efficient selection of primer sets for use in multiplex PCR reactions; reagents comprising primer sets for use in multiplex PCR reactions identified by the interlaced pipeline, an...
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WO/2024/050519A3 |
The present disclosure relates to the use of exosomal proteins to identify, diagnose, treat, and/or prevent ovarian cancer.
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WO/2024/097838A2 |
Provided herein according to some aspects is a method for processing a tissue sample from a subject, the sample comprising cells of a breast tissue site comprising or suspected of comprising ductal carcinoma in situ (DCIS), and detecting...
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WO/2024/094966A1 |
A method of controlling a biochemical analysis system for analysing polymers comprising a sequence of polymer units is provided. The system is operable to take successive measurements of a polymer from a sensor element during translocati...
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WO/2024/093519A1 |
The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase syste...
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WO/2024/097900A1 |
RNA molecules comprising a guide sequence portion having 17-50 contiguous nucleotides containing nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-2325 and compositions, methods, and uses thereof.
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WO/2024/097357A1 |
Described herein is a method of extracting and quantitating low density lipoprotein cholesterol (LDL-C) in a blood sample. The sample is first diluted or rehydrated in a reagent 1 to provide a diluted sample. The diluted sample is then m...
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WO/2024/092358A1 |
There is described herein a method of prognosing or classifying a subject with a Myeloproliferative Neoplasm (MPN) comprising: (a) determining the expression level of at least 10 genes in a test sample from the subject selected from the ...
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WO/2024/097744A2 |
The present invention provides methods of generating diverse chemical structures on DNA through Wittig olefination of novel on-DNA phosphorane ylides and Homer- Wadsworth-Emmons reaction of on-DNA β-keto phosphonates. The methods of thi...
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WO/2024/095161A1 |
The present disclosure describes methods for analyzing mRNA poly(A) tail sequences with a high resolution to determine poly (A) tail length and heterogeneity. The method involves digesting an mRNA molecule to liberate a poly(A) tail, pre...
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WO/2024/094858A1 |
The present invention relates to diagnosis of tuberculosis in saliva. In particular, the present invention relates to a method for determining whether a subject is likely to be infected with Mycobacterium tuberculosis (mt) by incubating ...
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WO/2024/097892A1 |
This disclosure relates to introducing specified endogenous amiRNA responsive to endogenous primary-miRNAs. This invention allows the degradation of amiRNAs in specific tissues, while allowing amiRNA to silence gene expression in other t...
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WO/2024/096354A1 |
The present invention relates to a pharmaceutical composition for preventing or treating kidney cancer comprising an IFITM3 inhibitor. According to a composition according to one aspect, the tumorigenesis inhibitory effect can be induced...
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WO/2024/094793A1 |
The present invention relates to the purification of linear DNA products, which may have nuclease-resistance. The linear DNA products may be double-stranded or single stranded. In addition, the present invention relates to purified linea...
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WO/2024/097373A1 |
Provided herein are methods and compositions relating to the use of single cell RNA sequencing to assess gene editing outcomes in transplanted populations of gene edited hematopoietic stem cells.
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WO/2024/096149A1 |
The embodiment provides a microbial analysis device comprising: an input part that receives a set of NGS analysis files for a target environment from an external NGS server; a preprocessing part that reads a forward read file and a rever...
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WO/2024/097856A1 |
The present disclosure is based on the identification of copy number of DPP9 gene and expression of a set of genes as biomarkers predictive of responsiveness to DPP inhibitors, particularly Talabostat or a pharmaceutically acceptable sal...
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WO/2024/097936A2 |
The present disclosure provides methods to detect a target in a sample by using a DNA scaffold with enzymatic activity ("DNAzyme") that catalyzes hydrogen peroxidase decomposition, leading to a reaction wherein bubbles are produced. In p...
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WO/2024/097257A1 |
Methods and compositions for monitoring mutation burden, cancer status, vaccine efficacy using cell-free DNA sequencing following enrichment with combination probe panels are disclosed.
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WO/2023/230551A3 |
Some embodiments of the methods and compositions provided herein relate to obtaining long read information from short reads of a target nucleic acid. Some embodiments include steps to selectively generate, mark, and amplify long nucleic ...
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WO/2024/093421A1 |
Provided are a surface treatment method, a sequencing method, and a kit for nucleic acid molecule extension. The surface treatment method comprises: contacting a phosphate compound with a surface bound with an oligonucleotide, wherein th...
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WO/2024/050514A3 |
A device, method, and kit are disclosed for use in detecting a target analyte in a sample. The device includes a region having a first zone, into which the sample can be delivered, and a second zone in fluid communication with the first ...
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WO/2024/096120A1 |
The present disclosure relates to improving the colonization properties of a bacterial preparation in a host. Specifically, the present disclosure relates to a microorganism wherein at least one gene is modified, said modification improv...
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WO/2024/073541A3 |
Novel genetically engineered thermostable Cas12b enzymes with lower-than-wildtype thermal stability, lower stability (than wild type) at "normal" reaction temps (around 65 °C), minimally enhanced activity, and/or no cleavage activity th...
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WO/2024/092713A1 |
Disclosed in the present invention is an MMLV reverse transcriptase mutant. Compared with the amino acid sequence of wild-type MMLV reverse transcriptase, the MMLV reverse transcriptase mutant provided in the present invention has mutati...
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WO/2024/096618A1 |
The present invention relates to a cancer risk prediction method and a composition thereof. The present invention was confirmed to be far superior to existing known SNP set combinations with respect to cancer risk prediction for Asian ca...
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WO/2024/094708A1 |
The present invention relates to a three-dimensional polynucleotide-based open shells for encapsulating a virus or viral particle, to a composition comprising a mixture of such three-dimensional polynucleotide-based open shells, to a com...
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WO/2024/095599A1 |
Provided is a method for producing glomus cell-like cells, the method including: (a) a step for inducing differentiation of pluripotent stem cells into autonomic progenitor cells; and (b) a step for culturing the autonomic progenitor cel...
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WO/2023/177526A9 |
The disclosure provides nucleic acid molecules (comprising expression cassettes), plasmids, protein molecules, cells (comprising nucleic acid molecules), and recombinant expression systems for producing recombinant cascade reagents for t...
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WO/2024/094817A1 |
The present invention relates to a score (TOPOSCORE) for describing eubiosis or dysbiosis in an individual, that can be used, inter alia, for determining if a patient is likely to respond to an immune-oncology treatment, more precisely, ...
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WO/2024/097758A1 |
Provided herein are methods of treating acute leukemia, such as acute myeloid leukemia (AML), in an individual, such as an individual having a mutation within the nucleophosmin 1 (NPM1) gene or a rearrangement within the lysine[K]-methyl...
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WO/2023/205510A3 |
The invention relates to compositions and methods for determining risk of developing myeloproliferative disorders. In certain embodiments, the invention includes screening for mutations in the genes JAK2, MPL (thrombopoietin receptor), a...
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WO/2024/097263A1 |
Systems, methods, compositions, and kits for measuring secreted analytes from cells are disclosed herein, including those capable of determining single cell secretion activity and protein expression and/or gene expression simultaneously....
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WO/2024/097893A2 |
Disclosed herein are fusion proteins and systems for detection of protein secretion. Also disclosed herein are methods for identifying at least one genomic region in a cell that modulates the secretion of a protein and methods for detect...
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WO/2024/092768A1 |
The present invention relates to a thermostable reverse transcriptase and use thereof. The thermostable reverse transcriptase has at least one of mutation positions L333, P65, Q68, P127, P175, E176, G178, G331, T332, F334, and G105, wher...
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WO/2024/094578A1 |
The present invention is directed to seedless fruit producing melon. The present invention also comprises methods for production of said plants and methods for producing seedless melon. Plants and plant parts of the invention comprise at...
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WO/2024/098076A1 |
Aspects of the present disclosure relate generally to methods, compositions, and kits for conjugating cells with magnetic beads. Aspects of the present disclosure also include methods, compositions, and kits for using magnetic bead conju...
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