METHODS AND COMPOSITIONS FOR SCREENING FOR MYELOPROLIFERATIVE DISORDERS

Title:

METHODS AND COMPOSITIONS FOR SCREENING FOR MYELOPROLIFERATIVE DISORDERS

Document Type and Number:

WIPO Patent Application WO/2023/205510

Kind Code:

A3

Abstract:

The invention relates to compositions and methods for determining risk of developing myeloproliferative disorders. In certain embodiments, the invention includes screening for mutations in the genes JAK2, MPL (thrombopoietin receptor), and CALR (calreticulin). In certain embodiments, the invention includes screening for mutations in the genes FLT3, IDH2, IDH1, KIT NPM1, and/or CEBPA. In certain embodiments, the invention includes screening for mutations in the genes WT1, ASXL1, RUNX1, DNMT3, and/or SF3B1.

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Inventors:

MOHAMED AYMAN (US)

Application Number:

PCT/US2023/019643

Publication Date:

May 10, 2024

Filing Date:

April 24, 2023

Export Citation:

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Assignee:

PRECIPIO INC (US)

International Classes:

C12Q1/6886; C07K14/715; C12N15/11; C12Q1/6858; C12Q1/6883

Attorney, Agent or Firm:

GUSTAFSON, Megan (US)

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