Title:
METHOD FOR ESTIMATION OF FETAL FRACTION IN CELL-FREE DNA FROM MATERNAL SAMPLE
Document Type and Number:
WIPO Patent Application WO/2024/059528
Kind Code:
A3
Abstract:
The digital amplification methods and kits provide the ability to estimate the fetal fraction of cell-free DNA (cfDNA) in a maternal sample, e.g., plasma or serum, by analysis of target sites that are differentially methylated in fetal and maternal cfDNA.
Inventors:
LI CHENYU (US)
MIKHAYLICHENKO OLGA (US)
HENDEL NATHAN (US)
HENRIQUEZ ANTHONY (US)
DANNEBAUM RICHARD (US)
HERRERA MONICA (US)
HALL ERIC (US)
MARGERIDON SÉVERINE (US)
RIEL THEA (US)
MIKHAYLICHENKO OLGA (US)
HENDEL NATHAN (US)
HENRIQUEZ ANTHONY (US)
DANNEBAUM RICHARD (US)
HERRERA MONICA (US)
HALL ERIC (US)
MARGERIDON SÉVERINE (US)
RIEL THEA (US)
Application Number:
PCT/US2023/073915
Publication Date:
May 10, 2024
Filing Date:
September 12, 2023
Export Citation:
Assignee:
BIO RAD LABORATORIES INC (US)
International Classes:
C12Q1/68; C12Q1/6827; C12Q1/6881; C12Q1/6883; G01N33/50
Attorney, Agent or Firm:
HINSCH, Matthew E. et al. (Suite 2800Mailstop: IP Docketing - 2, Atlanta Georgia, US)
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