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JP2022500023A |
The present disclosure provides transgenic cells and plants with increased or decreased expression of cellulose synthase-like G (CSLG) enzymes. In the recombinant cells and plants of the present invention, the content of steroidal alkalo...
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JP2021533823A |
For example, genetically modified bacteria of the class Actinobacteria, and the use of such bacteria in the biological conversion of steroid substrates to steroid products of interest. A method for converting a steroid substrate into a s...
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JP6976937B2 |
The present invention relates to a method for selectively producing ginsenoside F2, compound Mc or compound O, which is originally present in ginseng in a trace amount, from a saponin of ginseng, and more specifically to a method capable...
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JP2021141860A |
To provide a method for making components to be blended in a topical skin preparation or the like, without resort to natural trees when such components are difficult to obtain from the natural trees.A callus contains 6-hydroxygenistein 6...
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JP2021524733A |
The present invention relates to a modified sterol acyltransferase enzyme with enhanced activity and / or specificity for the acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) used in the bioengineering production of vit...
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JP6856528B2 |
Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-...
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JP6854815B2 |
The present invention relates to a method for selectively producing ginsenoside Rd, which is originally present in ginseng in a trace amount, from panaxadiol-type saponins of ginseng, and more specifically to a method capable of obtainin...
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JP6805246B2 |
The present invention relates to a method for selectively producing compound K and compound Y, which are originally present in ginseng in a trace amount, from saponins of ginseng, and more specifically to a method capable of obtaining de...
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JP2020072759A |
To provide a recombinant yeast for producing ginsenoside or precursor thereof, a method for producing the recombinant yeast, and a method for producing ginsenoside or precursor thereof at high yield by using the recombinant yeast.The pre...
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JP6694211B2 |
To provide a production method that enables synthesis of pentacyclic triterpene with its α22-position hydroxylated.The problem is solved by providing a transformant having CYP716A2 gene, which is cytochrome P450 monooxygenase derived fr...
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JP6666855B2 |
The invention relates to novel biocatalytic processes comprising the whole cell reduction of dehydrocholic acid (DHCA) compounds, novel 7β-hydroxy steroid dehydrogenase mutants, the sequences coding for these enzyme mutants, methods for...
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JP6645791B2 |
To provide a simple method for producing compositions containing ergosterol peroxide in a high concentration.(1) A method for producing a composition of ergosterol comprises the steps of: fermenting rice bran and/or rice germ to obtain a...
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JP6644433B2 |
The present invention relates to a terpenoid derivative that has the ability to activate the Keap1/Nrf2/ARE signaling pathway and is excellent in anti-inflammatory action and cytoprotective action, and a sustained-release pharmaceutical ...
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JP6635917B2 |
The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also...
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JP6633535B2 |
According to the present invention, there can be provided a process for producing 7-dehydrocholesterol (7DHC), comprising culturing, in a medium, a 7DHC-producing Labyrinthulea microorganism in which sterol 24-C-methyltransferase activit...
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JP6618180B2 |
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using...
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JP6608372B2 |
The present invention pertains to an isolated P450 enzyme comprising or consisting of an amino acid sequence at least 80% identical to SEQ ID NO: 1, wherein said sequence comprises a threonine at position corresponding to position 225 an...
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JP6605179B2 |
The present invention relates to a method for increasing the content of mogroside V in Siraitia grosvenorii suspended cells. In the method, 10-200 mg/L of a yeast inducer and 50-260 mg/L of methyl jasmonate are respectively added on days...
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JP6592101B2 |
The present invention provides an acyl-coenzyme A thiolase gene, genetically engineered strains and a use thereof. The present invention constructs genetically engineered Mycobacterium strains lacking of an acyl-coenzyme A thiolase gene,...
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JP6584899B2 |
To provide a simple manufacturing method of a stigmasterol-containing composition that contains the stigmasterol at a high concentration.(1) A manufacturing method of a stigmasterol-containing composition including obtaining a fermentati...
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JP2019103519A |
To provide a method and organism for utilizing synthesis gas or other gaseous carbon sources and methanol.According to the present invention, a non-naturally occurring microbial organism comprises an acetyl-CoA pathway and has the capabi...
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JP6533747B2 |
According to the present invention, there can be provided A process for producing 7-dehydrocholesterol (hereinafter, "7DHC"), comprising culturing, in a medium, a 7DHC-producing Labyrinthulea microorganism in which the 7DHC reducing acti...
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JP2019071860A |
To provide a method for producing sterol .Sterol is produced by culturing a Labyrinthula microorganism having a sterol production ability modified so as to reduce the activity of 24-dehydrocholesterol reductase (DHCR24) or sterol 24-C-me...
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JP2019068741A |
To provide algae that produce sterol, and a method for producing sterol using the same.Algae such as AJ7867 strain (FERM P-22304) and a strain derived therefrom, having a sterol production ability, are cultured. From bodies of the result...
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JP6470534B2 |
To provide a method for efficiently producing 1α, 25-dihydroxyvitamin Dfrom 25-hydroxyvitamin Dunder the presence of vitamin Dhydroxylase, a transformant which expresses this enzyme, and this transformant.The invention provides vitamin ...
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JP6438111B2 |
This application describes a method for preparing a fermented red ginseng powder dispersion with improved dispersibility and ginsenoside content. The method includes (a) grinding red ginseng to obtain powdered red ginseng; (b) introducin...
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JP6346435B2 |
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JP6328102B2 |
It is intended to provide a novel terpenoid derivative that exhibits anti-inflammatory action and a cytoprotective action by activating the Keap1/Nrf2/ARE signaling pathway. The present invention provides terpenoid derivative A represent...
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JP6329086B2 |
A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (...
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JP6305451B2 |
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JP6257634B2 |
The present invention relates to a novel uridine diphosphate (UDP)-glycosyltransferase, and particularly to a novel UDP-glycosyltransferase derived from ginseng and use thereof, a method for preparing glycosylated ginsenoside by converti...
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JP2017529860A |
The present invention provides methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds.
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JP6199742B2 |
In various aspects and embodiments, the invention provides a nucleic acid molecule comprising a nucleotide sequence encoding a 7β-hydroxysteroid dehydrogenase (7β-HSDH) mutant that catalyzes at least the stereospecific enzymatic reduct...
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JP2017073998A |
To provide sterol producing algae and methods for producing sterol using the same.Sterol is produced by culturing an alga with sterol production capability such as strain AJ7866 (FERM P-22289) and derivative strains thereof, and recoveri...
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JP6107130B2 |
To provide a new steroid 11β-hydroxylase useful for producing a 11β-hydroxysteroid such as a hydrocortisone.There is provided a protein of (a1), (b1) or (c1): (a1) a protein including a specific amino acid sequence, (b1) a protein incl...
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JP6110138B2 |
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JP2017042163A |
To establish a method for efficiently producing sterylglycoside having useful bioactivity, and provide cosmetic raw material or food and drink raw material.A method for producing sterylglycoside comprises the step of making phospholipase...
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JP6072180B2 |
Provided are a novel UDP-glycosyltransferase (uridine diphosphate glycosyltransferase) protein from Dolwoe (Gynostemma pentaphyllum) having glycosyltransfer activity for glucose linked by a glycosidic bond at the C-20 position of PPD (pr...
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JP6067862B2 |
The present invention relates to a novel uridine diphosphate (UDP)-glycosyltransferase, and particularly to a novel UDP-glycosyltransferase derived from ginseng and use thereof, a method for preparing glycosylated ginsenoside by converti...
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JP6023045B2 |
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JP6018915B2 |
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JP5990888B2 |
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JP2016520292A |
the present invention -- Aspa rutile * [-- asparagus -- a cancer vaccine treatment which makes Giniru ] *beta* hydroxylase (HAAH) a target is included. The present invention means a method for using the above-mentioned bacteriophage in a...
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JP5921883B2 |
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JP5889200B2 |
This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as Saccharomyces cerevisiae. It also relates to various enzymes catalyzing the reduction of the do...
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JP5881016B2 |
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JP5872671B2 |
New process for the regioselective enzymatic oxidation of bile acids, salts or derivatives thereof, such as cholic acid, chenodeoxycholic acid or cholic acid methyl ester, by NAD (P) +-dependent hydroxysteroid dehydrogenase (HSDH) in the...
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JP5800040B2 |
To provide acquisition of a high active P450 scc enzyme protein of P450 scc enzyme protein as an important enzyme protein catalyzing a first step of industrially useful steroid hormone biosynthesis.A sterol side chain cleavage enzyme pro...
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JP5781325B2 |
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JP5756137B2 |
The present invention provides a method for extracting lipids from microorganisms without using a nonpolar organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microo...
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