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WO/2011/054929A2 |
The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dediffere...
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WO/2011/038313A2 |
The present invention provides regio- and stereoselective oxidation of unactivated C-H bonds using an engineered mutant cytochrome P450 monooxygenase and an engineered substrate.
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WO/2011/000693A1 |
The present invention relates to an industrial process for the reduction of 4-androstene-3, 17-dione in order to obtain testosterone using a particularly stable and selective enzyme produced in a recombinant manner.
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WO/2010/133194A1 |
The invention relates to an isolated, genetically modified, living non-mammal organism, having increased HMG-CoA-reductase activity compared to the wild type, and having reduced C24-methyltransferase and/or delta22-desaturase activity co...
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WO/2010/095721A1 |
Disclosed is a P450 monooxygenase having heat resistance and organic solvent resistance. Also disclosed is a process for producing an oxide under a high-temperature environment or in an organic solvent by means of a P450 monooxygenase h...
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WO/2010/079594A1 |
P450scc enzyme protein is an important enzyme protein which can catalyze the first stage in an industrially useful steroid hormone biosynthesis. The invention aims to obtain P450scc enzyme protein having a high activity. Specifically dis...
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WO/2010/041619A1 |
An expression vector capable of expressing a foreign gene in Pseudonocardia autotrophica; a transformant of Pseudonocardia autotrophica produced by using the expression vector; a method for producing a protein by using the transformant; ...
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WO/2009/096445A1 |
Disclosed are a neural stem cell propagation accelerator which contains a compound produced by Penicillium sp. strain CND1007 (FERM BP-10917) or a pharmacologically acceptable salt thereof, a novel compound produced by Penicillium sp. st...
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WO/2009/067484A2 |
The subject application provides a regulatory region of the CYP11β2 sequence, called pause sequence. The pause sequence is present within the signal sequence of this protein and deletion of the pause sequence increases the speed of entr...
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WO/2009/024572A1 |
A method is described to construct genetically modified strains of steroid degrading micro-organisms wherein the method comprises inactivation of at least one gene involved in methylhexahydroindanedione propionate degradation. Strains wi...
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WO/2009/019138A2 |
The present invention refers to an enzymatic process for obtaining 17alpha-monoesters of cortexolone and/or its 9, 11-dehydroderivatives starting from the corresponding 17alpha, 21-diesters which comprises an enzymatic alcoholysis reacti...
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WO/2008/155999A1 |
Disclosed is a GABAergic neuron activator which is highly safe and can activate a GABAergic neuron. The GABAergic neuron activator comprises a fermented ginseng extract as an active ingredient.Also disclosed is a food or beverage which i...
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WO/2008/105513A1 |
Disclosed is a means for improving the poor conversion efficiency in a conventional bioconversion using a transformant having a gene derived from a heterogeneous organism integrated therein. A microorganism having the deletion of a gene ...
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WO/2008/096695A1 |
Disclosed are: isolated, pure DNA comprising at least one domain encoding a polypeptide associated with the hydroxylation of vitamin D; a polypeptide encoded by the DNA; a autonomously or integratively replicating recombinant plasmid car...
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WO/2007/138894A1 |
A vitamin D3 hydroxylase is purified from a culturedPseudonocardia autotrophica cell, and a primer is designed based on the information on amino acid sequence for the hydroxylase. Subsequently, PCR is conducted using genomic DNA of Pseud...
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WO/2007/118644A1 |
A process for the enantioselective enzymatic reduction of compounds which have a steroid structure (ABCD), including one or more heteroatoms, one or more double bonds and/or an aromatic in the ring structure and which have at least one o...
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WO/2007/112536A1 |
The present invention relates to the use of genetic engineering to produce sterol esters. In certain embodiments, an isolated or recombinant nucleic acid molecule encoding a sterol acyltransferase is disclosed. In certain other embodimen...
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WO/2007/095527A2 |
The present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces, such as natiostructures, caused by chemiluminescence based reactions. Importantly, these plasmonic emissions e...
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WO/2007/082891A1 |
The invention relates to the use of bacterial strains of the species Amycolatopsis mediterranei for the microbial transformation of 9β,10α-steroids of general Formula (I) to their corresponding 11β-hydroxyl analogues, as well as to sp...
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WO/2007/051317A1 |
Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acy...
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WO/2006/124141A2 |
The present invention relates to a process of using recombinant E. coli having a Δ1-dehydrogenase gene to prepare prednisolone. Specifically, the present invention relates to a fermentation process of using recombinant E. coli containin...
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WO/2006/006608A1 |
[PROBLEMS] To provide a process by which 5-ene-3-one or 3,6-dione derivatives of sterols can be synthesized in high yield; and processes for the production of lipid metabolism improvers, foods, drinks, and animal feeds, containing the de...
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WO/2005/121315A1 |
The invention concerns the production of cholesterol in organisms of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention ...
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WO/2005/095634A1 |
The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sec...
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WO/2005/085425A1 |
[PROBLEMS] To regulate the differentiation of a mesenchymal stem cell line originating in bone marrow into steroid-producing cells. [MEANS FOR SOLVING PROBLEMS] Mesenchymal stem cells can be differentiated into steroid-producing cells by...
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WO/2005/080572A1 |
Soyasapogenol B is biologically synthesized via two-step hydroxylation of β-amyrin which is its precursor. However, a gene of the hydroxylase participating in this reaction has not been clarified so far. Therefore, this hydroxylase cann...
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WO/2005/067673A2 |
Provided herein are enzymatic methods of producing steroid compounds S such as 7-dehydropregnenolone, hydroxy derivatives thereof and vitamin D2- and D3- like compounds and derivatives thereof. Also provided are the derivatives of the ...
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WO/2005/052178A1 |
The invention relates to a method of biological transformation using resting cells in cloud point system.The method forms a cloud point system below the microbiological transformating culturing temperature using one kind or more than one...
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WO/2005/047498A1 |
The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Sai...
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WO/2005/030977A1 |
The present invention relates to a microbial method for the simultaneous dehydrogenation and oxidation of 4-androsten-3,17-dione to produce 17a-oxo-D-homo-1,4-androstadiene-3,17-dione in high yield and high substrate concentrations, by m...
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WO/2005/014845A1 |
The invention relates to technology of microorganism. The invention declares a method of using cloud point system in biological transforming. The method forms a cloud point system below the microbiological transformating culturing temper...
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WO/2005/000865A1 |
A microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters is disclosed.
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WO2003070925A9 |
The invention relates to an isolated polynucleotide sequence comprising a nucleic acid sequence encoding the amino acid sequence of KshA protein or of KshB protein, encoded by nucleotides 499-1695 of SEQ ID NO: 1 or by nucleotides 387-14...
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WO/2004/095949A1 |
The present invention relates to fermented red ginseng comprising metabolites of ginseng saponins by the action of human intestinal bacteria having anti-obesity activity, energy improving activity or blood circulation improving effect an...
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WO/2004/083407A1 |
The invention relates to a method for producing ergosta-5,7-dienol and/or biosynthetic intermediate and/or secondary products thereof by cultivating genetically modified organisms. The invention also relates to the genetically modified o...
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WO/2004/070048A1 |
The invention relates to a fungal process to prepare 5-androsten-3beta, 7alpha, 15alpha-triol-17-one and related analogues using a species of the genus Fusarium capable of 7alpha, 15alpha-dihydroxylation.
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WO/2004/065612A1 |
A process to produce 19-nor-10β-carboxylic acids by fungal oxidation of 6-substituted-&Dgr 6-pregnanes is disclosed.
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WO/2004/057013A1 |
A process for producing 7&agr -hydroxypregn-4-en-3-one-20-carbaldehyde, characterized in that a microorganism which belongs to the genus Alcaligenes and acts on 3&agr ,7&agr -dihydroxy-5ß-cholanic acid and/or a salt thereof as a substra...
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WO/2004/050892A1 |
This invention relates to lactic fermenting products of ginseng obtained by fermentation of ginseng using lactic acid bacteria, yoghurt containing said lactic fermenting products of ginseng, and lactic acid bacteria used in the preparati...
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WO2004011663A9 |
Disclosed is a new synthetic pathway for the production of precursors for the production of compounds having general formula (8,10,12). During said synthesis, compounds of general formal (4,B) are produced in a microbiological reaction. ...
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WO/2003/099997A2 |
The steroidogenic acute regulatory protein (StAR), a mitochondrial protein required for stress responses, reproduction, and sexual differentiation of male fetuses is shown to exert its activity transiently at the outer mitochondrial memb...
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WO/2003/092578A2 |
The present invention relates to improved methods for synthesising cyproterone acetate (17&agr -Acetoxy-6-chloro-1&agr , 2&agr -methylene-4,6-pregnadiene-3,20-dione) from solasodine. The methods of the invention are shorter as those of t...
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WO/2003/064652A1 |
The invention relates to a method for the production of zymosterol the biosynthetic intermediate or subsequent products thereof by cultivation of organisms, in particular yeasts, which have an increased lanosterol C14-demethylase activit...
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WO/2003/064653A2 |
The invention relates to a method for overexpressing dehydrogenases, especially for overexpressing &Dgr 1 dehydrogenases, especially for overexpressing 3-ketosteroid-&Dgr 1 dehydrogenases. The invention also relates to the bacteria, plas...
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WO/2003/064674A2 |
A process of fermenting a phytosterol composition to produce androstenedione (androst−4−ene−3,17−dione) and subsequently androstadienedione (and rosta−1,4−diene,3,17−dione) comprises propagating a microbial culture of the g...
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WO/2003/064650A1 |
The invention relates to a method for the production of 7-dehydrocholesterol and/or the biosynthetic intermediate or subsequent products thereof by the cultivation of organisms, in particular, yeasts which show an increased activity of a...
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WO/2003/040383A1 |
A process for preparing 20-$g(b)-D-pyranoglucosyl-protopanaxadiol by enzymatic hydrolysis of ginsenoside, which comprises steps of hydrolysis, collection and is caracterized in glycosyl in the molecular of diol type of ginsenoside being ...
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WO/2003/023047A1 |
7&agr −Hydroxypregn−4−en−3−one−20−carbaldehyde&semi a process for producing the carbaldehyde&semi and a process by which 7&agr ,21−dihydroxy−20−methylpregn−4−en−3−one having a high purity, which is useful as a...
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WO/2002/102826A1 |
The present invention is a novel process for the transformation of 17$g(a)-hydroxy-6$g(a)-methylpregn-4-ene-3,20-dione 17-acetate (Formula (I)) to 11$g(b),17$g(a),21-trihydroxy-6$g(a)-methylpregna-1,4-diene-
3,20-dione 21-acetate (Formul...
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WO/2002/101053A1 |
It is intended to provide proteins having an activity of digesting saponin, more specifically, proteins capable of digesting a glycoside having soyasapogenol B as an aglycone and thus producing soyasapogenol B&semi polynucleotides encodi...
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