Fermentation or Enzyme-Using Processes To Synthesise A Desired Chemical Compound or Composition or To Separate Optical Isomers From A Racemic Mixture

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JP2015133969A	SOLVENTLESS EXTRACTION PROCESS To provide a process for extracting, recovering, isolating or obtaining lipids from microorganisms.The present invention provides a method for extracting lipids from microorganisms without using a nonpolar organic solvent as an extractio...
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JP2015082970A	METHOD FOR PRODUCING PANAX GINSENG EFFECTIVE INGREDIENT To provide a method for producing a Panax ginseng effective ingredient which decomposes Rb1 contained in Panax ginseng extract as an ingredient into an effective ingredient through the decomposition route to Rd, and does not decomposes t...
JP5684989B2	Enzyme-treated product of Dioscorea esculenta and fermented product of Jiuqu To provide a composition originated from Dioscorea esculenta rhizome richly containing diosgenin glycoside useful in the fields of foods, medicines, and cosmetics, to provide a method for efficiently producing the composition, and to pro...
JP5670310B2	Cholesterol-producing yeast strain and its use A fungus (A) that can produce cholesterol (I) autonomously, is new. Independent claims are also included for: (1) production of (I) by culturing (A); (2) production of (I) or its metabolic intermediates or a mixture of sterols labeled by...
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JP5646992B2	Enzymatic method for obtaining 17α-monoester of cortexolone and / or 9,11-dehydro derivative thereof The present invention refers to new crystalline forms of cortexolone 17α-propionate and their pharmaceutical use.
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JP5506403B2	Neural stem cell growth promoter A proliferation promoting agent for neural stem cells, which comprises a compound produced by Penicillium sp. CND1007 (FERM BP-10917) or a pharmaceutically acceptable salt thereof, as an active ingredient; a novel compound produced by Pe...
JP5461082B2	New microorganisms belonging to the genus Streptomyces, new compounds produced by the microorganisms, and drugs containing the compounds as active ingredients. To provide a compound having anticancer activities and antibacterial activities.The new microorganism produces the new compound represented by formula (I). The anticancer agent, the infiltration inhibitor of the surrounding tissue of a c...
JP2014050357A	FERMENTATION PRODUCT CONTAINING HYDROXIDE OF GLYCYRRHETINIC ACID, PRODUCTION METHOD THEREOF, PRODUCTION METHOD OF HYDROXIDE OF GLYCYRRHETINIC ACID, AND WHITENING AGENT, ANTI-AGING AGENT, HAIR GROWTH AGENT, HAIR COSMETIC, AND SKIN COSMETIC To provide a production method of a fermentation product containing the hydroxide of glycyrrhetinic acid which effectively and easily produces a fermentation product containing the hydroxide of glycyrrhetinic acid from glycyrrhizin, a pr...
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JP2013511973A	New 7β-Hydroxysteroid dehydrogenase and its use The present invention relates to a novel 7β-hydroxysteroid dehydrogenase obtained from Collinsella bacteria, especially Collinsella aerofaciens strain, a sequence encoding the enzyme, a method for producing the enzyme, and enzymatic con...
JP5113832B2	Process for the preparation of steroid derivatives by reduction of oxosteroid compounds or by oxidation of hydroxysteroid compounds with hydroxysteroid dehydrogenase A process for the enantioselective reduction of compounds having a steroid structure (ABCD) including one or several heteroatoms, one or several double bonds and/or aromatic components in the ring structure and having at least one oxo gr...
JP2012239412A	GENE FOR CODING ENZYME THAT REDUCE POSITION 24 OF STEROID SKELETON To provide a gene for coding an enzyme that reduces the position 24 of a steroid skeleton, and a method for producing steroids and vitamin D3.Disclosed are an enzymatic conversion method for reducing the double bond at the 24 position of...
JP5053838B2	Cholesterol-producing yeast strain and its use A fungus (A) that can produce cholesterol (I) autonomously, is new. Independent claims are also included for: (1) production of (I) by culturing (A); (2) production of (I) or its metabolic intermediates or a mixture of sterols labeled by...
JPWO2010095721A1	Fusion monooxygenase and oxide production method using it An object of the present invention is to provide a P450 monooxygenase system having heat resistance and organic solvent resistance. Another object of the present invention is to provide a method for producing an oxide in a high temperatu...
JP4998957B2	Hydroxidase gene and its uses A vitamin D 3 hydroxylase is purified from Pseudonocardia autotrophica cell, and a primer is designed based on amino acid sequence obtained from hydroxylase. Subsequently, PCR is conducted using genomic DNA of Pseudonocardia autotrophica...
JPWO2010079594A1	Sterol side chain cleavage enzyme protein and its utilization An object of the present invention is to obtain a highly active P450scc enzyme protein for the P450scc enzyme protein, which is an important enzyme protein that catalyzes the first stage of industrially useful steroid hormone biosynthesi...
JP4953547B2	Ginsenoside glycosidases that hydrolyze ginsenoside sugar groups and their use The invention relates to ginsenoside glycosidases which hydrolyzes ginsenosides having higher contents in ginsengs so as to prepare rare ginsenosides with high physioloigical activity. Said ginsenoside glycosidases are derived from micro...
JP2012060974A	METHOD FOR ARTIFICIALLY CULTURING MUSHROOM, AND METHOD FOR PRODUCING GANODERENIC ACID COMPOUNDS To provide a method for artificially culturing a mushroom, which uses coffee extracted grounds as the main raw material of a culture medium (mushroom bed), and to provide a method for producing a ganoderenic acid compound, comprising sep...
JP2012024084A	NEW YEAST, AND METHOD OF PRODUCING Δ5,7-STEROL AND HYDROCORTISONE USING THE SAME To provide a method of efficiently producing Δ5,7-sterol of cholesta-5,7,24-trien-3β-ol or the like and hydrocortisone.The Δ5,7-sterol and the hydrocortisone are produced using a yeast modified so that the expression of an acyl-CoA: s...
JP4864277B2	Utilization for the production of modified yeast and especially steroid derivatives The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having...
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JP2011526481A	New 12α-hydroxysteroid dehydrogenase, its manufacture and use 12alpha -Hydroxysteroid dehydrogenase (12alpha -HSDH), obtained from Clostridium sp.and having a molecular weight of 27-30 kD, is new. Independent claims are included for: (1) 12alpha -HSDH-mutant with a modified cosubstrate-utilization;...
JP4769868B2	Method for producing corosolic acid by suspension culture of plant cells The present invention relates to a method of producing corosolic acid by using plant cells that produce corosolic acid. More particularly, the present invention relates to a method of producing corosolic acid by using plant cell suspensi...
JP2011517945A	Method A method for reducing the amount of cholesterol and/or improving the texture and/or reducing weight loss and/or increasing the fat stability of a meat based food product comprising: a) contacting meat with a lipid acyltransferase; b) inc...
JP2011115078A	IMPROVEMENT OF VITAMIN D HYDROXYLASE To provide a method for efficiently producing a hydroxylated vitamin D derivative while suppressing the side reaction in the hydroxylation reaction of vitamin Ds by modifying a hydroxylase such as Vdh-K1 structurally associated with Vdh ...
JP4699661B2	Ruscus aculeatus Method for producing derivatives of steroid glycosides A process for the preparation of desglucodesrhamnoruscin which comprises the hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) through fermentation of a substrate containing said glycosides by means of fungi of the asperg...
JP4668176B2	Triterpene hydroxylase Soyasapogenol B is biosynthesized via two steps of hydroxylation reaction of its precursor ²-amyrin. However, the gene of the hydroxylase concerned in this reaction has not been revealed. Therefore, it was impossible to apply a genetic ...
JP2011024534A	22 POSITION HYDROXYLASE To solve a problem in that soyasapogenol B is bio-synthesized by the ring closure of 2,3-oxidosqualene produced from β-amyrin which is a bio-synthetic precursor of the soyasapogenol B, through a mevalonic acid pathway and further throug...
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JP4620932B2	Yeast strain that autonomously produces steroids The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains.
JP4606523B2	Biological method for producing 25-position hydroxide of steroids
JP4603220B2	Method for Producing Derivatives of Ruscus aculeatus Steroid Glycoside by Enzymatic Hydrolysis A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) by means of crude hydrolases from aspergillus niger.
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JP2010531660A	9 α-Hydroxy-steroid synthesis method The present invention relates to a novel selective synthesis of 9α-hydroxy-steroid derivatives of the general formula (I) (I)—wherein the meaning of -A-A′- is —CH2—CH2— or —CH═CH— group—by the bioconversion of compound...
JP4549625B2	Fine emulsified particles containing ginseng saponin metabolite as an active ingredient, a method for producing the fine particles, and a cosmetic composition for preventing skin aging containing the fine emulsified particles. Disclosed herein is nanoemulsion prepared by emulsifying main metabolites of ginseng saponin obtained by conversion of glucose, i.e. compound K (20-O- beta -D-glucopyranosyl-20(S)-protopanaxadiol), ginsenoside F1 (20-O- beta -D-glucopyra...
JP4548849B2	How to differentiate mesenchymal stem cells into steroid-producing cells To control the differentiation of mesenchymal stem cells into steroid hormone producing cells. Mesenchymal stem cells can be differentiated into steroid hormone-producing cells by being stimulated by a transcriptional factor (SF-1), pref...
JP4545255B2	Panax Kinkforium Ginsenosides-Producive Callus
JP2010193809A	METHOD FOR PRODUCING FEEDING CENTER-SUPPRESSING SUBSTANCE To provide a method for producing a feeding center-suppressing substance.The method for producing the feeding center-suppressing substance comprises a step of fermenting a caralluma fruit and caffeine with lactobacillus. The feeding cent...
JP4537887B2	Solvent-free extraction process The present invention provides a method for extracting lipids from microorganisms without using a nonpolar organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microo...
JP2003501045T6	A manufacturing method of a derivative of a Ruscus aculeatus steroid glycoside A manufacturing method of デスグルコデスラムノラシン including hydrolysis of the glycoside through fermentation by a fungus Aspergillus niger kind of a substrate containing a Ruscus aculeatus steroid glycoside (Lascaux sapon...
JP2003501044T6	A manufacturing method of a derivative of a Ruscus aculeatus steroid glycoside by enzymatic hydrolysis A manufacturing method of デスグルコデスラムノラシン which uses crude hydrolase of Aspergillus niger origin and including enzymatic hydrolysis of a Ruscusaculeatus steroid glycoside (Lascaux saponin).
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JP4460300B2	Methods for overexpression of dehydrogenase Es wird ein Verfahren zur Überexpression von Dehydrogenasen, besonders zur Überexpression von DELTA1-Dehydrogenasen, insbesondere zur Überexpression von 3-Ketosteroid-DELTA1-Dehydrogenasen, sowie die für die Überexpression verwendba...
JP2010099075A	PROCESS FOR PREPARATION OF GRANULAR MICROBIAL BIOMASS AND ISOLATION OF INVALUABLE COMPOUND FROM THE BIOMASS To provide a process for the isolation of desired compounds from a microbial biomass.A process for the isolation of desired compounds from a microbial biomass is provided, wherein the microbial biomass (which, if necessary, is pretreated...

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