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WO/1993/021205A1 |
A method is provided for isolating 5,7-diene-containing steroids, particularly 3 beta-ols and esters of 3 beta-ols, from a sterol mixture. The method involves (1) treating the mixture with a dienophile or with an oxidizable dienophile pr...
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WO/1993/005170A1 |
Described is a method of preparing 14$g(a)-hydroxy-4-androstene-3,17-dione with a culture of $i(Curvularia lunata). The method is characterized in that 4-androstene-3,17-dione is suspended in water and the suspension thus obtained fermen...
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WO/1992/003572A1 |
Described is a method of preparing 17-oxosteroids by the fermentative oxidation of 17$g(b)-hydroxysteroids, characterized in that a bacterial culture of the species Mycobacterium spec. NRRL B-3805, Mycobacterium spec. NRRL B-3683, Mycoba...
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WO/1992/003571A1 |
The description relates to a process for producing 4-pregnene-3,20-dione and its derivatives of general formula (I) in which: R¿1? is a hydrogen or fluorine atom or a methyl group; R¿2? is a hydrogen atom of a hydroxy group; and R¿3? ...
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WO/1992/003465A1 |
Disclosed are 20-methyl-5,7-pregnadiene-3$g(b),21-diol derivatives of general formula (I), in which R¿1? is a hydrogen atom or a lower-alkyl group and R¿2? is a lower-alkyl group, or R¿1? and R¿2? together represent a tetramethylene ...
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WO/1992/001803A1 |
The present invention relates to a method for hydroxylation of an acyclic or cyclic methylene radical in the allylic position, characterized in that a peroxydase, iodide ions and hydrogen peroxyde (H2O2) are reacted on said methylene rad...
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WO/1991/007483A2 |
The invention provides methods for the purification to homogeneity of pancreatic cholesterol esterase in useful quantities from a variety of mammalian species. The gene for a mammalian pancreatic cholesterol esterase has been cloned and ...
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WO/1990/013559A1 |
The invention relates to novel 9alpha-hydroxy-3-oxo-4,24(25)-stigmastadien-26-oic acid derivatives of general formula (I), wherein M stands for hydrogen, C1-4 alkyl or a pharmaceutically acceptable cation. Further the invention relates t...
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WO/1990/003428A1 |
Genetically engineered host cells are provided which are able to carry out simultaneously oxidations of steroids, preferably the simultaneous introduction of the 17alpha-hydroxyl and the C21-hydroxyl group. In particular the oxidation is...
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WO/1989/012064A1 |
1beta,15alpha-Dihydroxy-1alpha-methyl-5alpha-androstan-3,17-
dione of formula (I) and its subsequent processing to pharmacologically active steroids.
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WO/1989/010963A1 |
Genetically engineered host cells containing new expression cassettes are provided which are able to carry out biochemical oxidations of steroids. In particular the oxidation is carried out with cells into which DNA has been introduced w...
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WO/1988/007122A1 |
The present invention relates to an arrangement for a door or other covering element which consists of a moving door leaf (3) capable of being formed to adopt the desired path of the door, which door leaf is so arranged as to be capable ...
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WO/1988/007092A1 |
The present invention involves processes for 1,2-dehydrogenation of DELTA4-3-keto C21-hemiester steroids of formula (I), with Arthrobacter simplex or Bacterium cyclooxydans to produce the corresponding DELTA1,4-3-keto C21 hemiester of fo...
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WO/1988/005782A1 |
Compounds of formula (I), wherein X represents =O or H(alpha)OH(beta), and Y represents H(alpha) or OH(alpha), which are prepared by bringing 4-pregnene-3,20-dione into contact with microorganisms belonging to the genus Acremonium. These...
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WO/1988/005781A1 |
Compounds of formula (I), wherein X represents =O or H(alpha)OR(beta), Y represents H2 or OH(alpha)H(beta), Z represents H or OH(alpha), and R represents H, COCH3, COCH2CH3, COCH(CH3)2 or COC(CH3)3, which are prepared by bringing androst...
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WO/1987/005940A1 |
Process for the production of 17aalpha-hydroxy-D-homo-1,4-pregnadiene-3,20-dion of formula (I) characterized by the fact that 3beta,17aalpha-dihydroxy-D-homo-5-pregnene-20-one of formula (II) is fermented with Bacillus lentus ATCC 13805.
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WO/1987/003620A1 |
Process for manufacturing 4-androstene-3,17 dion and 1,4 androstadiene-3,17-dion of the general formula (I) where ..... is a simple bond or a double bond, characterized by the fact that alpha-sitosterine of formula (II) is fermented with...
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WO/1986/007385A1 |
Process for the preparation of 4-androstene-3,17-dione and of 1,4-androstadiene-3,17-dione having the formula (I) wherein ..... represents a single bond or a double bond, characterized in that ergosterol of formula (II) is fermented with...
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WO/1986/005813A1 |
A process for producing 1-methyl-1,4-androstadiene-3,17-dione characterized by the fact that 1-methyl-5alpha-androst-1-ene-3,17-dione (Metenolon) is fermented with a micro-organism culture of the genera Norcardia, Mycobacterim or Fusarium.
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WO/1985/005126A1 |
Anaerobic fermentation caused by inoculation, in the purified sisal juice, of microorganisms of rumen mixed with a salt solution. The process demands a pH control, an anaerobic environment, a temperature around 37oC, a 50-70 r.p.m. agita...
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WO/1983/004264A1 |
Method for enhancing the degradation of the side chain of sterols possessing branched chains at C-24 utilizing microbiological means by including an exogenous source of bicarbonate ion (HCO3-) in the medium in which the degradation is be...
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WO/1981/002427A1 |
Process for the fermentation of bile which includes the step of cultivating one or more aerobic microorganisms which have the ability to selectively degrade bile acids or bile acid conjugates contained in bile. The fermentation is carrie...
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WO/1981/000113A1 |
Biocatalysts for production or transformation of natural products having their origin in higher plants, are obtained by immobilization of whole cells, protoplasts, protoplasts with regenerated cell walls, hybride cells or cell complexes ...
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WO/1980/002027A1 |
Ergostadientriols which may be recovered from either the fungus R. oligosporus or the fungus R. oryzae as well as from soybeans which have been fermented with either of these fungi. Alternatively, the sterols may be chemically synthesize...
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JP7460540B2 |
The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of...
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JP7443658B2 |
The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features...
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JP7443657B2 |
The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features...
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JP2024507239A |
Virucidal compositions, methods of making them, related uses, and end-user products are provided herein. The composition is prepared from a selected fungal strain Ganoderma lucidum (MUS12, MUS15, MUS18 and MUS23) in an essentially liquid...
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JP2024001138A |
The present invention provides a method for 21-hydroxylation of steroids in cells. A method for hydroxylating carbon atom 21 of a steroid, the method comprising: a) (i) a heterologous CYP21A2 protein or an unmodified heterologous CYP21A2...
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JP2023177322A |
To provide, for example, an Aspergillus oryzae LGYM4 strain.The invention relates to: an Aspergillus oryzae LGYM4 strain; a red ginseng fermentation product including the strain or a fermentation product thereof: a food composition, a co...
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JP7364611B2 |
Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-...
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JP7327937B2 |
[Problem] The purpose of the present invention is to provide a new method for producing a cycloastragenol analog from astragaloside IV. {Solution] A method for producing a cycloastragenol analog that includes a contact step that brings a...
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JP2023530667A |
Biosynthetic processes for producing sterol derivatives and non-naturally occurring organisms capable of producing sterol derivatives are provided. More specifically, genetically modified non-naturally occurring organisms are provided fo...
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JP2023090723A |
To provide compositions of very long chain unsaturated fatty acids (VLCFAs) having beneficial health effects in order to supply these fatty acids required in the body, where the provision of VLCFAs is limited, since there is a very limit...
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JP2023520307A |
The present invention provides a 7-deoxysteroid having the general formula (I) at the 7-position a steroid having the general formula (II) Enzymes and methods for hydroxylating to
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JP7275163B2 |
The present invention relates to a use of a microorganism of the classfor promoting gut health of a healthy subject. Also provided is a method for the production of chenodeoxycholic acid (CDCA) and a method for the production of lithocho...
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JP2023516682A |
The present invention comprises converting a 7-deoxysteroid with a cytochrome P450 enzyme or a functional variant thereof in the presence of at least one redox partner system and a system for regenerating the redox partner system. It rel...
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JP2023512283A |
The present invention provides novel recombinant Bacillus megaterium cytochrome P450-monooxygenase (P450-BM3) mutants for C19 hydroxylation of steroids and their derivatives or for improved BM3 protein expression ( variant). In particula...
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JP7205480B2 |
A method for producing a sterol is provided. A sterol is produced by culturing a Labyrinthulea microorganism having a sterol-producing ability, which has been modified so that the activity of 24-dehydrocholesterol reductase (DHCR24), 7-d...
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JP7157237B2 |
The present invention relates to a recombinant yeast strain having sterol productivity, a preparation method therefor and a use thereof, and more specifically, to a recombinant yeast strain capable of producing cholesterol and cholestero...
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JP7151279B2 |
To provide method for producing sterol.Labyrinthula microorganisms having a sterol production ability modified for an increased activity of diacylglycerol acyltransferase (DGAT) are cultured, sterol is recovered from the culture, so that...
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JP7150451B2 |
To provide novel fermented products comprising ginsenoside F2 (F2), compositions comprising the fermented products and methods for producing the fermented products.Disclosed herein is a fermented product produced by fermenting at least o...
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JP2022119755A |
To provide a production method of 14-dehydroergosterol.A production method of 14-dehydroergosterol (14-DHE) comprises culturing microbes of the genus Aspergillus to produce 14-DHE, where the initial spore concentration of the microbes in...
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JP7094494B2 |
To provide an Apocynaceae Catharanthus transgenic plant body in which a foreign gene is introduced into the genome.The present invention provides a transgenic plant body in which a foreign gene is introduced into the genome of an Apocyna...
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JP7090266B2 |
The present invention provides a cytochrome P450 mutant protein and applications thereof. In particular, in the present invention, after the modification of key sites in the cytochrome P450 CYP716A47, the PPD production and the PPD/DM pr...
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JP7053907B1 |
To provide a method for producing 14-dehydroergosterol. According to the present invention, there is a method for producing 14-dehydroergosterol (14-DHE), which comprises a step of culturing a microorganism belonging to the genus Aspergi...
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JP2022519711A |
The present invention relates to genetically modified bacteria, and in particular to their industrial application in 1,2-dehydrogenation of steroids.
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JP7035034B2 |
The present invention relates to a coupled biotransformation process of converting chenodeoxycholic acid (CDCA) and related compounds to ursodeoxycholic acid (UDCA) and related compounds. It also relates to the cloning, expression, and b...
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JP2022022980A |
To provide a method and so on for producing a novel fermented product.A fermented carrot is produced through enzymatic treatment with lactase and fermentation treatment with Lactobacillus lactic acid bacteria.SELECTED DRAWING: None
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JP7012293B2 |
The purpose of the present invention is to provide a transgenic plant in which 7-dehydrocholesterol, which is a precursor to active VD3, is produced in an increased amount, and a technique for using the same. This problem is solved by pr...
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